Automating a 96-well microtiter plate assay for identification of AGEs inhibitors or inducers: application to the screening of a small natural compounds library

Advanced glycation end-products (AGEs) are involved in the pathogenesis of numerous affections such as diabetes and neurological diseases. AGEs are also implied in various changes in tissues and organs. Therefore, compounds able to break them or inhibit their formation may be considered as potential drugs, dietary supplements, or bioactive additives. In this study, we have developed a rapid and reliable (Z′ factor calculation) anti-AGEs activity screening based on the overall fluorescence of AGEs. This method was successfully evaluated on known AGEs inhibitors and on a small library of natural compounds, yielding coherent results when compared with literature data.     

Coexistence of Two Thermally Induced Intramolecular Electron Transfer Processes in a Series of Metal Complexes [M(Cat‐N‐BQ)(Cat‐N‐SQ)]/[M(Cat‐N‐BQ)2] (M=Co,Fe, and Ni) bearing Non‐Innocent Catechol‐Based Ligands: A Combined Experimental and Theoretical Study

The different thermally induced intermolecular electron transfer (IET) processes that can take place in the series of complexes [M(Cat‐N‐BQ)(Cat‐N‐SQ)]/[M(Cat‐N‐BQ)₂], for which M=Co ( 2 ), Fe ( 3 ) and Ni( 4 ), and Cat‐N‐BQ and Cat‐N‐SQ denote the mononegative (Cat‐N‐BQ^?) or dinegative (Cat‐N‐SQ^2?) radical forms of the tridentate Schiff‐base ligand 3,5‐di‐tert‐butyl‐1,2‐quinone‐1‐(2‐hydroxy‐3,5‐di‐tert‐butylphenyl)imine, have been studied by variable‐temperature UV/Vis and NMR spectroscopies. Depending on the metal ion, rather different behaviors are observed. Complex 2 has been found to be one of the few examples so far reported to exhibit the coexistence of two thermally induced electron transfer processes, ligand‐to‐metal (IET^LM) and ligand‐to‐ligand (IET^LL). IET^LL was only found to take place in complex 3 , and no IET was observed for complex 4 . Such experimental studies have been combined with ab initio wavefunction‐based CASSCF/CASPT2 calculations. Such a strategy allows one to solicit selectively the speculated orbitals and to access the ground states and excited‐spin states, as well as charge‐transfer states giving additional information on the different IET processes.     

Convex hull: A new method to determine the separation space used and to optimize operating conditions for comprehensive two-dimensional gas chromatography

It is important to develop methods of optimizing the selection of column sets and operating conditions for comprehensive two-dimensional gas chromatography. A new method for the calculation of the percentage of separation space used was developed using Delaunay's triangulation algorithms (convex hull). This approach was compared with an existing method and showed better precision and accuracy. It was successfully applied to the selection of the most convenient column set and the geometrical parameters of second column for the analysis of 49 target compounds in wastewater.     

Change of angle in tent spaces

We prove sharp bounds for the equivalence of norms in tent spaces with respect to changes of angles. Some applications are given.     

Majorana edge states in interacting one-dimensional systems

We show that one-dimensional electron systems in the proximity of a superconductor that support Majorana edge states are extremely susceptible to electron-electron interactions. Strong interactions generically destroy the induced superconducting gap that stabilizes the Majorana edge states. For weak interactions, the renormalization of the gap is nonuniversal and allows for a regime in which the Majorana edge states persist. We present strategies of how this regime can be reached.     

无零级衍射干扰的彩色数字全息研究

彩色数字全息研究中,用球面波为重建波及角谱衍射公式进行波前重建是一种有效的方法.然而,重建图像上通常伴有强烈的零级衍射干扰.本文通过理论分析,对波前重建过程作了重要改进.用改进后的方法进行彩色数字全息的实验研究表明,重建彩色图像的质量获得显著改善. 关键词： 彩色数字全息 波前重建 零级衍射干扰     

Measurement of an Efimov trimer binding energy in a three-component mixture of 6Li

The binding energy of an Efimov trimer state was precisely determined via radio-frequency association. It is found that the measurement results shift significantly with temperature, but that the shift becomes negligible at the lowest temperature in our experiment. The shift-free part of the trimer binding energy reveals a significant deviation from the nonuniversal theory prediction based on a three-body parameter with a monotonic binding-energy dependence.     

Experimental investigation of harmonic and subharmonic synchronization of 40 GHz mode-locked quantum-dash laser diodes

Synchronization of a 40 GHz quantum-dash mode-locked (ML) Fabry-Perot laser diode with optically injected pulse streams is experimentally studied. Injected signals consist of nonmodulated and modulated trains of 1.6 ps pulses at various repetition rates, ranging from 10 to 160 GHz and 10 to 160 Gbps, respectively. Subharmonic, fundamental, and harmonic synchronization of the ML laser allows retrieval of stable 40 GHz clock pulses featuring a width of 1.8 ps. Frequency components at 10 and 20 GHz do not create any amplitude modulation on the recovered 40 GHz clock pulses when injecting signals at 10 and 20 GHz/Gbps. In addition, external synchronization of the laser with pulse streams at 80 and 160 GHz/Gbps is sustained despite the absence of significant components at or below 40 GHz.     

Conical stochastic maximal L^p-regularity for 1\leqslant p<\infty

Let \(A = -\mathrm{div} \,a(\cdot ) \nabla \) be a second order divergence form elliptic operator on \({\mathbb R}^n\) with bounded measurable real-valued coefficients and let \(W\) be a cylindrical Brownian motion in a Hilbert space \(H\) . Our main result implies that the stochastic convolution process $$\begin{aligned} u(t) = \int _0^t e^{-(t-s)A}g(s)\,dW(s), \quad t\geqslant 0, \end{aligned}$$ satisfies, for all \(1\leqslant p<\infty \) , a conical maximal \(L^p\) -regularity estimate $$\begin{aligned} {\mathbb E}\Vert \nabla u \Vert _{ T_2^{p,2}({\mathbb R}_+\times {\mathbb R}^n)}^p \leqslant C_p^p {\mathbb E}\Vert g \Vert _{ T_2^{p,2}({\mathbb R}_+\times {\mathbb R}^n;H)}^p. \end{aligned}$$ Here, \(T_2^{p,2}({\mathbb R}_+\times {\mathbb R}^n)\) and \(T_2^{p,2}({\mathbb R}_+\times {\mathbb R}^n;H)\) are the parabolic tent spaces of real-valued and \(H\) -valued functions, respectively. This contrasts with Krylov’s maximal \(L^p\) -regularity estimate $$\begin{aligned} {\mathbb E}\Vert \nabla u \Vert _{L^p({\mathbb R}_+;L^2({\mathbb R}^n;{\mathbb R}^n))}^p \leqslant C^p {\mathbb E}\Vert g \Vert _{L^p({\mathbb R}_+;L^2({\mathbb R}^n;H))}^p \end{aligned}$$ which is known to hold only for \(2\leqslant p<\infty \) , even when \(A = -\Delta \) and \(H = {\mathbb R}\) . The proof is based on an \(L^2\) -estimate and extrapolation arguments which use the fact that \(A\) satisfies suitable off-diagonal bounds. Our results are applied to obtain conical stochastic maximal \(L^p\) -regularity for a class of nonlinear SPDEs with rough initial data.