全文获取类型
收费全文 | 16864篇 |
免费 | 2801篇 |
国内免费 | 2264篇 |
专业分类
化学 | 13144篇 |
晶体学 | 177篇 |
力学 | 851篇 |
综合类 | 167篇 |
数学 | 1943篇 |
物理学 | 5647篇 |
出版年
2024年 | 55篇 |
2023年 | 354篇 |
2022年 | 577篇 |
2021年 | 627篇 |
2020年 | 772篇 |
2019年 | 811篇 |
2018年 | 600篇 |
2017年 | 512篇 |
2016年 | 879篇 |
2015年 | 899篇 |
2014年 | 986篇 |
2013年 | 1211篇 |
2012年 | 1494篇 |
2011年 | 1453篇 |
2010年 | 1021篇 |
2009年 | 967篇 |
2008年 | 1090篇 |
2007年 | 974篇 |
2006年 | 825篇 |
2005年 | 767篇 |
2004年 | 641篇 |
2003年 | 620篇 |
2002年 | 731篇 |
2001年 | 666篇 |
2000年 | 429篇 |
1999年 | 367篇 |
1998年 | 221篇 |
1997年 | 197篇 |
1996年 | 182篇 |
1995年 | 164篇 |
1994年 | 118篇 |
1993年 | 102篇 |
1992年 | 107篇 |
1991年 | 120篇 |
1990年 | 101篇 |
1989年 | 54篇 |
1988年 | 50篇 |
1987年 | 34篇 |
1986年 | 37篇 |
1985年 | 33篇 |
1984年 | 29篇 |
1983年 | 12篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1980年 | 5篇 |
1979年 | 7篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1957年 | 1篇 |
1936年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 17 毫秒
51.
In this paper, we present a fully Lagrangian method based on the radial basis function (RBF) finite difference (FD) method for solving convection–diffusion partial differential equations (PDEs) on evolving surfaces. Surface differential operators are discretized by the tangent plane approach using Gaussian RBFs augmented with two-dimensional (2D) polynomials. The main advantage of our method is the simplicity of calculating differentiation weights. Additionally, we couple the method with anisotropic RBFs (ARBFs) to obtain more accurate numerical solutions for the anisotropic growth of surfaces. In the ARBF interpolation, the Euclidean distance is replaced with a suitable metric that matches the anisotropic surface geometry. Therefore, it will lead to a good result on the aspects of stability and accuracy of the RBF-FD method for this type of problem. The performance of this method is shown for various convection–diffusion equations on evolving surfaces, which include the anisotropic growth of surfaces and growth coupled with the solutions of PDEs. 相似文献
52.
Benzothiadiazole(BT) is an electron-deficient unit with fused aromatic core, which can be used to construct conjugated polymers for application in organic solar cells(OSCs). In the past twenty years, huge numbers of conjugated polymers based on BT unit have been developed,focusing on the backbone engineering(such as by using different copolymerized building blocks), side chain engineering(such as by using linear or branch side units), using heteroatoms(such as F, O and S atoms, and CN group), etc. These modifications enable BT-polymers to exhibit distinct absorption spectra(with onset varied from 600 nm to 1000 nm), different frontier energy levels and crystallinities. As a consequence, BT-polymers have gained much attention in recent years, and can be simultaneously used as electron donor and electron acceptor in OSCs, providing the power conversion efficiencies(PCEs) over 18% and 14% in non-fullerene and all-polymer OSCs. In this article, we provide an overview of BTpolymers for OSCs, from donor to acceptor, via selecting some typical BT-polymers in different periods. We hope that the summary in this article can invoke the interest to study the BT-polymers toward high performance OSCs, especially with thick active layers that can be potentially used in large-area devices. 相似文献
53.
54.
Zhihui Xiao ZuYin Zhang Wei Guo 《International Journal of Infrared and Millimeter Waves》2001,22(4):553-569
In this paper, the DVRT (vector radiative transfer theory of densely distributed random discrete scatters) model to calculate the brightness temperature emitted by radiometer calibration load is presented. It takes the multiple scattering of isolation layer into account, which is neglected by the incoherent homogeneous model often used in calibration. Hence, it works much better than incoherent homogeneous model at millimeter wave band. Furthermore, the iteration of DVRT model is presented, and it proves that the incoherent homogeneous model is just the zero-order solution of DVRT model. Some numerical results are provided in the end. 相似文献
55.
Hui Ma Lulu Xiao Dongchen Xu Yingrui Geng Xuesong Liu Yong Chen Yongjiang Wu 《Molecules (Basel, Switzerland)》2022,27(9)
Quality control methods of current traditional Chinese medicine (TCM) preparation is time-consuming and difficult to assess in terms of overall efficiency of the drug. A non-destructive rapid near-infrared spectroscopy detection system for key chemical components and biological activity of Lanqin oral solution (LOS), one of the best-selling TCM formulations, was established for comprehensive quality evaluation. Near infrared spectral scanning was carried out on 101 batches of commercial LOS under the penetrated vial state and traditional state. RAW 264.7 cells were cultured to detect the anti-inflammatory ability of LOS, and the reference concentrations of epigoitrin, geniposide, and baicalin were obtained by HPLC. The quantitative models were optimized by three kinds of variable selection methods. The correlation coefficients of prediction value of the models were greater than 0.94. The system also passed the external validation. The performance of the non-invasive models was similar to the traditional models. The established non-destructive system can be applied to the rapid quality inspection of LOS to avoid unqualified drugs from entering the market and ensure drug effectiveness. The biological activity index of LOS was introduced and predicted by NIRs for the first time, which provides a new idea about the quality control of TCM formulations. 相似文献
56.
Alexey Sulimov Danil Kutov Ivan Ilin Yibei Xiao Sheng Jiang Vladimir Sulimov 《Molecules (Basel, Switzerland)》2022,27(9)
The COVID-19 pandemic is still affecting many people worldwide and causing a heavy burden to global health. To eliminate the disease, SARS-CoV-2, the virus responsible for the pandemic, can be targeted in several ways. One of them is to inhibit the 2′-O-methyltransferase (nsp16) enzyme that is crucial for effective translation of viral RNA and virus replication. For methylation of substrates, nsp16 utilizes S-adenosyl methionine (SAM). Binding of a small molecule in the protein site where SAM binds can disrupt the synthesis of viral proteins and, as a result, the replication of the virus. Here, we performed high-throughput docking into the SAM-binding site of nsp16 for almost 40 thousand structures, prepared for compounds from three libraries: Enamine Coronavirus Library, Enamine Nucleoside Mimetics Library, and Chemdiv Nucleoside Analogue Library. For the top scoring ligands, semi-empirical quantum-chemical calculations were performed, to better estimate protein–ligand binding enthalpy. Relying upon the calculated binding energies and predicted docking poses, we selected 21 compounds for experimental testing. 相似文献
57.
Suxia Li Kang Lin Huaiyu Pang Yixin Wu Jianhe Xu 《Applied biochemistry and biotechnology》2013,169(2):612-623
An organic solvent-tolerant lipase from Serratia marcescens ECU1010 (rSML) was overproduced in Escherichia coli in an insoluble form. High concentrations of both biomass (50 g cell wet weight/L culture broth) and inclusion bodies (10.5 g/L) were obtained by applying a high-cell-density cultivation procedure. Activity assays indicated that the enzymatic activity of rSML reached 600 U/L. After treatment with isopropyl ether for 12 h, the maximum lipase activity reached 6,000 U/L. Scanning electron microscopy and Fourier transform infrared microspectroscopy revealed the activation mechanism of rSML in the presence of organic solvents. rSML was stable in broad ranges of temperatures and pH values, as well as in a series of organic solvents. Besides, rSML showed the best enantioselectivity for the kinetic resolution of (±)-trans-3-(4-methoxyphenyl)glycidic acid methyl ester. These features render the S. marcescens ECU1010 lipase attractive for biotechnological applications in the field of organic synthesis and pharmaceutical industry. 相似文献
58.
59.
A highly convenient method for N-formylation of amines via treatment by formic acid in the presence of melamine trisulfonic acid as a catalyst has been developed. This method showed improvements over previous reports in terms of yield, reaction time and chemoselectivity. 相似文献
60.
Hcp-icosahedron structural transformation induced by the change in Ag concentration during the freezing of (CoAg)561 clusters 下载免费PDF全文
The synergy effect of alloy elements in bimetallic clusters can be used to tune the chemical and physical properties. Research on the influences of alloy concentration and distribution on the frozen structure of bimetallic clusters plays a key rolc in exploring new structural materials. In this paper, we study the influence of Ag concentration on the frozen structure of the (AgCo)561 cluster by using molecular dynamics simulation with a general embedded atom method. The results indicate that tt~e structure and chemical ordering of the (AgCo)561 cluster are strongly related to Ag concentration. Hcp-icosahedron structural transformation in the frozen (CoAg)561 cluster can be induced by changing Ag concentration. The chemical ordering also transforms to Janus-like Co Ag from core-shell Co-Ag. 相似文献