Spyridon Dimitrakis  Efthymios-Spyridon Gavriil  Athanasios Pousias  Nikolaos Lougiakis  Panagiotis Marakos  Nicole Pouli  Katerina Gioti  Roxane Tenta 《Molecules (Basel, Switzerland)》2022,27(1)

A number of pyrrolo[2,3-c]pyridines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines were designed and synthesized as antiproliferative agents. The target compounds possessed selected substituents in analogous positions on the central scaffold that allowed the extraction of interesting SARs. The cytotoxic activity of the new derivatives was evaluated against prostatic (PC-3) and colon (HCT116) cell lines, and the most potent analogues showed IC₅₀ values in the nM to low µM range, while they were found to be non-toxic against normal human fibroblasts (WI-38). Flow cytometric analysis of DNA content revealed that the most promising derivative 14b caused a statistically significant accumulation of PC-3 cells at G₂/M phase and induced apoptosis in PC-3 cells.  相似文献   

    

Panagiotis Loginos  Anastasios Patsidis  Katerina Vrettos  George Sotiriadis  Georgios C. Psarras  Vassilis Kostopoulos  Vasilios Georgakilas 《Molecules (Basel, Switzerland)》2022,27(20)

In this work, UV-curable resin poly (ethylene glycol) diacrylate (PEGDA) was reinforced with three different types of nanofillers: pristine graphene (G), multiwalled carbon nanotubes (MWNTs), and a hybrid of MWNTs and graphene 70/30 in mass ratio (Hyb). PEGDA was mixed homogenously with the nanofiller oligomer by shear mixing and then photopolymerized, affording thin, stable films. The thermomechanical properties of the afforded nanocomposites indicated the superior reinforcing ability of pristine graphene compared with MWNTs and an intermediate behavior of the hybrid.  相似文献   

    

Michelyne Haroun  Anthi Petrou  Christophe Tratrat  Aggeliki Kolokotroni  Maria Fesatidou  Panagiotis Zagaliotis  Antonis Gavalas  Katharigatta N. Venugopala  Nagaraja Sreeharsha  Anroop B. Nair  Heba Sadek Elsewedy  Athina Geronikaki 《Molecules (Basel, Switzerland)》2022,27(23)

A series of previously synthesized 5-benzyliden-2-(5-methylthiazole-2-ylimino)thiazoli- din-4-one were evaluated for their anti-inflammatory activity on the basis of PASS predictive outcomes. The predictive compounds were found to demonstrate moderate to good anti-inflammatory activity, and some of them displayed better activity than indomethacin used as the reference drug. Structure–activity relationships revealed that the activity of compounds depends not only on the nature of the substituent but also on its position in the benzene ring. The most active compounds were selected to investigate their possible mechanism of action. COX and LOX activity were determined and found that the title compounds were active only to COX-1 enzymes with an inhibitory effect superior to the reference drug naproxen. As for LOX inhibitory activity, the derivatives failed to show remarkable LOX inhibition. Therefore, COX-1 has been identified as the main molecular target for the anti-inflammatory activity of our compounds. The docking study against COX-1 active site revealed that the residue Arg 120 was found to be responsible for activity. In summary, the 5-thiazol-based thiazolidinone derivatives have been identified as a novel class of selective COX-1 inhibitors.  相似文献   

    

Pierre‐Louis Lions  Panagiotis E. Souganidis 《纯数学与应用数学通讯》2003,56(10):1501-1524

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Panagiotis A. Tsonis  Anastasios A. Tsonis 《Complexity》2002,7(4):13-15

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Pierre-Louis Lions  Benoît Perthame  Panagiotis E. Souganidis 《纯数学与应用数学通讯》1996,49(6):599-638

We prove the existence and compactness (stability) of entropy solutions for the hyperbolic systems of conservation laws corresponding to the isentropic gas dynamics, where the pressure and density are related by a γ-law, for any γ > 1. Our results considerably extend and simplify the program initiated by DiPerna and provide a complete existence proof. Our methods are based on the compensated compactness and the kinetic formulation of systems of conservation laws. © 1996 John Wiley & Sons, Inc.  相似文献   

    

Panagiotis Konstantis  Frank Loose 《Mathematische Nachrichten》2016,289(13):1648-1664

We classify pairs where M is a 3‐dimensional simply connected smooth manifold and G a Lie group acting on M transitively, effectively with compact isotropy group.  相似文献   

    

Stylianos Panagiotakis;Emmanouil Giannoudis;Asterios Charisiadis;Raphaella Paravatou;Maria-Eleni Lazaridi;Maria Kandyli;Kalliopi Ladomenou;Panagiotis A. Angaridis;Hélène C. Bertrand;Ganesh D. Sharma;Athanassios G. Coutsolelos; 《欧洲无机化学杂志》2018,2018(20-21):2369-2379

Two novel porphyrins, ZnP(SP)CNCOOH and ZnPCNCOOH, bearing cyanoacrylic acid as an anchoring group were synthesized. Porphyrin ZnP(SP)CNCOOH contains a π-conjugated spacer (SP) for improved electronic communication between the dye and the TiO2 electrode. The spacer bears polyethylene glycol chains to prevent dye aggregation and to enhance solubility of the dye. Electrochemical measurements and theoretical calculations suggest that both porphyrins are promising sensitizers for dye-sensitized solar cells (DSSCs), as their molecular orbital energy levels favor electron injection and dye regeneration. Solar cells sensitized by ZnP(SP)CNCOOH and ZnPCNCOOH show power conversion efficiencies of 7.61 and 5.02 %, respectively. Photovoltaic measurements (J–V curves and incident photon to current conversion efficiency spectra) show that higher short-circuit current (Jsc) and open-circuit voltage (Voc) values are reached for the solar cell based on ZnP(SP)CNCOOH. This can be mainly ascribed to suppressed charge recombination, as indicated by their electrochemical impedance spectra.  相似文献   

    

Panagiotis D. Vellis  John A. Mikroyannidis  Min Ju Cho  Dong Hoon Choi 《Journal of polymer science. Part A, Polymer chemistry》2008,46(16):5592-5603

Two new soluble alternating carbazolevinylene‐based polymers POXD and PTPA as well as the corresponding model compounds MOXD and MTPA were synthesized by Heck coupling. POXD and MOXD contained 2,5‐diphenyloxadiazole segments, while PTPA and MTPA contained triphenylamine segments. All samples displayed high thermal stability. The polymers had higher glass transition temperature (T_g) than their corresponding model compounds. The samples showed absorption maximum at 364–403 nm with optical band gap of 2.62–2.82 eV. They emitted blue‐green light with photoluminescence (PL) emission maximum at 450–501 nm and PL quantum yields in THF solution of 0.15–0.36. The absorption and the PL emission maxima of PTPA and MTPA were blue‐shifted as compared to those of POXD and MOXD . The electroluminescence (EL) spectra of multilayered devices made using four materials exhibited bluish green emissions, which is well consistent with PL spectra. The EL devices made using poly(vinyl carbazole) doped with MOXD and MTPA as emitting materials showed luminances of 12.1 and 4.8 cd m^?2. POXD and PTPA exhibited 25.4, and 96.3 cd m^?2, respectively. The polymer containing the corresponding molecules in the repeating group showed much higher device performances. Additionally, POXD and MOXD exhibited better stability of external quantum efficiency (EQE) and luminous efficiency with current density resulting from enhancing the electron transporting properties. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 5592–5603, 2008  相似文献   

    

Despoina Vrantza  Panagiotis Kaloudis  Leondios Leondiadis  Thanasis Gimisis  Georgios&#x;C. Vougioukalakis  Michael Orfanopoulos  Didier Gasparutto  Jean Cadet  Susana Encinas  Cecilia Paris  Miguel&#x;A. Miranda 《Helvetica chimica acta》2006,89(10):2371-2386

The photochemistry of N‐hydroxypyridine‐2(1H)‐thione (NHPT), inserted as a photolabile modifier at the 6‐position of 2′‐deoxyguanosine or guanosine, has been evaluated. In particular, 6‐[(1‐oxidopyridin‐2‐yl)sulfanyl]‐ ( 1a ) and 6‐[(pyridin‐2‐yl)sulfanyl]‐2′,6‐dideoxyguanosine ( 2a ), novel photolabile derivatives of the natural nucleosides, were synthesized and characterized. The observed photolysis products of 1a in organic solvents could only be rationalized by assuming a rapid equilibrium with the corresponding 6‐[(2‐thioxopyridin‐1(2H)‐yl)oxy] analogue 3a (Scheme 5). Transient spectroscopy of 1a indicated a strong triplet‐excited state suitable for triplet → triplet energy transfer or singlet‐oxygen generation. The NHPT function was stable enough for (slightly modified) automated solid‐phase oligonucleotide synthesis. The utility of the above compounds is discussed, as well as their potential use in photosensitization of reactive oxygen species in DNA.  相似文献