FC-空间上的不动点定理和相交定理及其应用

介绍了没有凸结构和线性结构的有限连续拓扑空间(简称为FC-空间);得到了若干个非紧的FC-空间上不动点定理的开[闭]表现形式并建立了FC-空间上的连续选择定理.应用以上结果,在非常弱的假设下得出若干的相交定理和重合点定理,改进和推广了文献中的相应结果.     

类W-KKM(X,Y,Z),几乎不动点定理和不动点定理

引进了相对弱$R$-子集和类($W$-)KKM$(X,Y,Z)$的概念,给出了相对KKM映射与相对弱$R$-子集之间的等价关系以及$W$-KKM$(X,Y,Z)$的一个性质,然后给出了两个连续选择定理并得到不动点定理和重合点定理, 最后,在一致拓扑空间上得到具有弱-KKM性质的映射的几乎不动点,不动点和重合点的存在定理.     

威客电子商务作弊评价模型及算法研究

威客模式是一种新型电子商务模式,有助于知识、智慧、经验、技能体现经济价值,是电子商务应用领域的一个热点.在介绍威客电子商务模式的基础上,重点研究了影响威客电子商务发展的作弊问题,建立了作弊评价模型.利用威客的历史信息和对设计方案相似性的评价,设计了一种基于定量和定性指标的作弊可能性计算算法.根据威客电子商务的特点,探讨了基于任务金额、结合作弊评价结果的威客信用评价体系.以猪八戒威客网站两个作弊争议案例为例进行了实证分析,说明了作弊评价算法的有效性.     

Quantum dots for positional registration in live cell-based arrays

For a better understanding of complex biological processes, it is desirable to simultaneously follow the dynamics of multiple components in living cells or organisms in real time. An encoding scheme was developed that enables the observation of multiple cell populations with single-cell resolution. Specifically, different yeast cell types were labeled with quantum dots and added to an array of microwells, where they randomly self-assemble into the complementary-sized cavities. Quantum dots conjugated to cells externally, internally, or in combination generated unique optical patterns to differentiate various cell types in the array. For the model system described herein, cells were monitored for their lacZ expression levels through the processing of a fluorescent precursor by ß-galactosidase. The encoding schemes employed were independent of the reporter emission and had no affect on the cellular activity. The live cell array platform allowed analysis of hundreds of individual cells simultaneously and continuously in real time. By coupling this platform with quantum dot cell labeling, the utility of this array format is extended to mixed cellular populations.

聚醚醚酮／聚醚砜嵌段共聚物的动态力学行为

本文以聚醚醚酮和聚醚砜两种齐聚物为原料合成了聚醚醚酮／聚醚砜嵌段共聚物，用动态力学谱仪对其进行了动态力学性能研究。从无定形共聚物样品对数减量－温度谱图中观察到清晰而完全分离的玻璃化转变内耗峰和非晶态向结晶态转变（α＇转变）内耗峰，确认α＇转变发生在冷结晶初期而后很快减弱。     

EFFECTS OF CHAIN STRUCTURE OF POLYPYRROLONES ON THE ELECTRICAL PROPERTIES OF PYROLYZED POLYPYRROLONES

Three kinds of polypyrrolones (PMDA-DAB, PMDA-TADPE and DEDA-DAB) werepyrolyzed at high temperature in order to study the effect of the chain structure of polypyrro-lones on the electrical properties of the pyrolyzed polymers. Results show that the num-ber of fusing rings in the main chain of polymers has a little effect on the pyrolysis pro-cess, whereas, the ether bond in the main chain plays an important role during pyrolysis.Structure characterizations by elemental analyis, XPS spectra, X-ray diffraction and SEMimages indicate that because the ether bond is easy to break, it is difficult to form largearea planar network. This hampers the formation of the graphite-like structure in thepolypyrrolones containing ether bond even after being pyrolyzed at 1200℃.     

SYNTHESIS OF OLIGOMERS CONTAINING 5-FLUOROURACIL

The condensation oligomers of 5-fluorouracil were prepared by reaction of 2,4-bis-(trimethyl-silyloxy)-5-fluoropyrimidine) with various dicarboxylic chlorides, e.g.The structures of obtained oligomers were characterized by IR and the oligomers were then hydrolyzed in acid, alkaline and neutral media at room temperature respectively. The amount of 5-fluorouracil released was quantitated by measuring its UV absorbance at 265.5nm. However in the case of oligomers containing phenylene moiety, 5-fluorouracil was not detected when the hydrolysis was conducted in acid or neutral medium, while in the case of oligomers containing methylene moiety, hydrolysis proceeded easily in acid, alkaline and neutral media.     

酰亚胺基取代α,β—不饱和酮的合成及二烯烃环加成反应的研究

在吡啶中肉桂酰氯与相应的酰亚胺化合物反应，分别合成了1－丁二酰亚胺基－3－苯基丙烯酮、1－邻苯二甲酰亚胺基－3－苯基丙烯酮、1－丁二酰亚胺基－3－间硝基苯基丙烯酮和1－邻苯二甲酰亚胺基－3－间硝基苯基丙烯酮。研究了所合成的这些酰亚胺基取代的α，β－不饱和酮分别与环戊二烯和异戊二烯的环加成反应活性。生成的环加成产物均为新的化合物，其结构经元素分析、IR和^1H NMR确证。     

7-取代苯氧基-4,5-二氢-1,2,4-三唑并[4,3-a]喹啉和喹啉-1(2H)-酮衍生物的合成及抗惊厥活性

合成了7-取代苯氧基-4,5-二氢-1,2,4-三唑并[4,3-a]喹啉(3a～3g)和7-取代苯氧基-4,5-二氢-1,2,4-三唑并[4,3-a]喹表明啉-1(2H)-酮(4a～4g)类衍生物. 以最大电惊厥法和戊四唑法测定了抗惊厥活性, 以旋转棒法测定了神经毒性. 结果表明, 化合物7-(4-氟苯氧基)-4,5-二氢-1,2,4-三唑并[4,3-a]喹啉-1(2H)-酮(4c)显示最强的抗惊厥作用和低的神经毒性, 其抗电惊厥ED₅₀为6.8 mg/kg, 神经毒性TD₅₀为88.0 mg/kg, 保护指数PI为12.9, 明显优于对照药苯妥英钠.     

泛昔洛韦在NaOH修饰玻碳电极上的伏安行为及测定

泛昔洛韦为一种新型抗病毒药[1],2-[2-(氨基-9H-嘌呤-9-基)乙基]-1,3-丙二醇二醋酸酯,其结构如右图所示,服药后可能使人的神经系统、消化系统等产生异常反应。有头晕、恶心、腹痛、消化不良等副作用,因此,有必要建立一种简便、快速、准确的分析方法测定药物制剂的含量,以进行药