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991.
[structure: see text]. The most powerful DNA microarrays would be prepared by photolithography with free 3'-ends that could be processed enzymatically. A photoremovable group that could be removed in quantitative yield would ensure high purity of the synthesized probes. We have developed new pyrimidine building blocks for 5' --> 3' DNA synthesis with high cycle yields using the NPPOC (3'-nitrophenylpropyloxycarbonyl) protecting group. These phosphoramidites were proved in automated photochemical DNA synthesis on a modified synthesizer. 相似文献
992.
N. S. Prostakov A. V. Varlamov B. N. Anisimov N. M. Mikhailova G. A. Vasil'ev P. I. Zakharov M. A. Galiullin 《Chemistry of Heterocyclic Compounds》1978,14(9):997-1003
A number of tertiary aza-9-fluorenols were obtained from 4- and 2-azafluofenones and were subjected to dehydration in order to synthesize the previously unknown 9-methyleneazafluorenes. The corresponding 9-methyleneazafluorenes and their polymers were obtained simultaneously in relatively stable form from both pyridine-ring-substituted and -unsubstituted 4-aza-9-fluorenols and from 1,3-diphenyl-2-aza-9-fluorenol. On the basis of an analysis of the mass spectrum of the polymer obtained from 9-methylene-4-azafluorene it was concluded that it is evidently isolated in the form of two dimers — dispiro [bis (4-aza-9-fluorene)-1, 3-cyclobutane] and the analogous product of dispiro addition with a 1,2-substituted cyclobutane ring. Condensation of the corresponding azafluorenes with benzaldehyde gave their 9-benzylidene derivatives in the form of geometrical isomers, the structures of which were established on the basis of the PMR spectra.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1234–1240, September, 1978. 相似文献
993.
The total synthesis of rac-sceletium alkaloid A41a and of its 3'-demethoxy analogue 1b via the annulation of endocyclic enamines 4a–b is presented. The Michael acceptor 5a is a useful synthon for the two-step synthesis of 2,3-disubstituted pyridines from Δ2-pyrrolines. 相似文献
994.
Dullens RP Claesson EM Kegel WK 《Langmuir : the ACS journal of surfaces and colloids》2004,20(3):658-664
We report a single step preparation of monodisperse fluorescent poly(methyl)methacrylate (PMMA) lattices cross-linked with ethylene glycol dimethacrylate with radii in the range 150-1000 nm using dispersion polymerization. The particles are applied as fluorescent cores in core-shell PMMA particles for confocal microscopy (Dullens et al. Langmuir 2003, 19, 5963). Contrary to un-cross-linked particles, these cross-linked colloids are stable in good solvents for PMMA as well. Therefore we studied the properties of the cross-linked PMMA particles in the good solvents tetrahydrofuran (THF), chloroform, and toluene using light scattering and confocal scanning laser microscopy. We show that the particles swell instantaneously and that their volume can increase up to more than seven times their volume in poor solvents. Further, it is very likely that the particles are charged in THF. 相似文献
995.
General solutions of the capillary pressure for liquids as a function of contact angle and volume in planar close-packed spheres have been calculated numerically using Surface Evolver software. Applied pressure differences between liquid and vapor result in undulating (puckered) menisci exhibiting anticlastic curvature in the narrower spaces near particle contacts. The corresponding capillary pressures exhibit maxima with infiltration volume (minima with drainage), corresponding to critical pressures for engulfment of the spheres by the liquid (vapor). The analysis also reveals the formation of residual pendular rings of the wetting phase around particle contacts. Pendular ring formation is explored further by analyzing hexagonally packed spheres separated by 1/10 their radius. The results are discussed relative to the wide range of approximate solutions available in the literature. 相似文献
996.
Assessment of the retention properties of poly(vinyl alcohol) stationary phase for lipid class profiling in liquid chromatography 总被引:3,自引:0,他引:3
Potentialities of polymerized vinyl alcohol on silica gel were assessed for class separation of simple lipids, sphingolipids, glyceroglycolipids and phospholipids by high-performance liquid chromatography. A screening of pure solvents in binary gradient elution and a chemometric approach was used to define a rugged two segment linear gradient formed from four solvents for total lipid class separation. Triethylamine and formic acid were added in all mobile phase components for acidic phospholipid separation and evaporative light scattering response enhancement. Simple analytical procedures are described for the analysis of complex lipid materials. 相似文献
997.
V. Kalcheva Kh. Lozanova D. Simov P. B. Terent'ev 《Chemistry of Heterocyclic Compounds》1985,21(9):985-987
3-Acetylaminomethyl-2-benzoxazolones are obtained by Beckmann rearrangement of the anti-oximes of 3-acetonyl-2-benzoxazolones. The isomeric 3-(N-methylcarbamoylmethyl)-2-benzoxazolones are synthesized by alkylation of 2-benzoxazolone with chloroacetic acid, followed by reaction of the 3-carboxymethyl-2-benzoxazolones obtained with thionyl chloride and methylamine.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1185–1188, September, 1985. 相似文献
998.
C. FRESNEAU B. ARRIO B. LECUYER A. DUPAIX N. LESCURE P. VOLFIN 《Photochemistry and photobiology》1984,39(2):255-261
Abstract— The fluorescence of scaleworms has been attributed by Harvey (1952) to a product of the bioluminescent reaction confined in the scales of these worms. We have purified this fluorescent molecule by gel filtration. This compound has an apparent low molecular weight as shown by polyacrylamide gel clectrophoresis in the presence of SDS. The yield of the fluorescent product, after gel filtration, varies with the stimulation of the bioluminescence, triggered either chemically or enzymatically. The fluorescence spectrum of the purified product is similar to the one observed in vivo , with a maximum centered at 520 nm. Consequently, the fluorescent compound isolated is likely the reaction product of the bioluminescent reaction. 相似文献
999.
V. P. Lesnyak D. I. Shiman L. V. Gaponik F. N. Kaputskii A. I. Lamotkin Zh. V. Bondarenko 《Russian Journal of Applied Chemistry》2007,80(2):295-299
The influence exerted by copolymers of the C9 fraction of liquid pyrolysis products of petroleum raw materials with maleic anhydride and by their esterification products, added to paper pulp, on the main paper properties was examined. 相似文献
1000.
F. dall'Acqua S. Caffieri D. Vedaldi A. Guiotto P. Rodighiero 《Photochemistry and photobiology》1983,37(4):373-379
By irradiating (365 nm) an aqueous liquid solution of 4,5'-dimethylangelicin. a monofunctional photosensitizing furocoumarin, in the presence of an excess of thymine, two new compounds, I and II, have been obtained; they do not show fluorescence when observed with Wood's light. The nuclear magnetic resonance data, the marked similarity of UV absorption and fluorescence spectra of these compounds with those of synthetic 3.4-dihydro-4,5'-dimethylangelicin and their capacity to undergo photodissociation (254 nm) yielding the starting thymine and 4,5'-dimethylangelicin in equimolecular amounts, are consistent with C4 -cycloadducts between the 3,4-double bond of the furocoumarin and 5,6-double bond of thymine. Nuclear magnetic resonance data indicate for I and II a head-to-head and a head-to-tail structure, respectively. When irradiation is carried out in the frozen state, two adducts. III and IV, fluorescent at Wood's light, have been obtained other than the two above-mentioned compounds I and II. Compounds III and IV have been identified as 4'.5'-fluorescent adducts between the 4',5'-double bond of the furocoumarin and the 5.6-double bond of thymine; one of them (III) is identical to that formed in the photoreaction between DNA and 4,5'-dimethylangelicin; for this last compound a cis head-to-head structure has been suggested. 相似文献