A round robin exercise in archaeometry: analysis of a blind sample reproducing a seventeenth century pharmaceutical ointment

Chemical analysis of ancient residues of pharmaceutical or cosmetic preparations such as balms or ointments is made problematic by the high complexity of these mixtures, composed of organic and inorganic materials. Consequently, a multi-analytical approach and special caution in the interpretation of the results are necessary. In order to contribute to the improvement of analytical strategies for the characterization of complex residues and to reconstruct ancient medical practices, a replica of a pharmaceutical formulation of the seventeenth century was prepared in the laboratory according to a historically documented recipe. In a round robin exercise, a portion of the preparation was analysed as a blind sample by 11 laboratories using various analytical techniques. These included spectroscopic, chromatographic and mass spectrometric methods. None of the laboratories was able to completely reconstruct the complex formulation, but each of them gave partial positive results. The round robin exercise has demonstrated that the application of a multi-analytical approach can permit a complete and reliable reconstruction of the composition. Finally, on the basis of the results, an analytical protocol for the study of residues of ancient medical and pharmaceutical preparations has been outlined.     

A multi-analytical approach for the characterization of powders from the Pompeii archaeological site

Nine black powders found in Pompeii houses in three different types of bronze vessels (cylindrical theca atramentaria, unguentaries, and aryballoi) were characterized in order to assess a correspondence between the composition and the type of vessel and, possibly, to verify if these powders were inks or not. For the compositional characterization, a multi-analytical approach was adopted, which involved the use of scanning electron microscopy-energy dispersive X-ray, Fourier-transformed infrared spectroscopy, Raman, X-ray diffraction, electron paramagnetic resonance spectroscopy, thermogravimetric analysis, gas chromatography coupled with mass spectrometry (GC/MS), and pyrolysis GC/MS. Powders contained in cylindrical theca atramentaria form a homogeneous group, and their organic and inorganic compositions suggest that they were writing inks, while powders contained in unguentaries and aryballoi could have had several different uses, including writing inks and cosmetics. Furthermore, the composition profile of the powders found in cylindrical cases shows that, at 79?AD: , in Pompeii, carbon-based inks were still used for writing, and iron gall inks had not been introduced yet.     

A Comparative Study of Turbulence in Ramp-Up and Ramp-Down Unsteady Flows

DNS of a turbulent channel flow subjected to a step change in pressure gradient are performed to facilitate a direct comparison between ramp-up and ramp-down flows. Strong differences are found between behaviours of turbulence in the two flows. The wall shear stress in the ramp-up flow first overshoots, and then strongly undershoots the quasi-steady value in the initial stage of the excursion, before approaching the quasi-steady value. In a strongly decelerating flow, the wall shear stress tends to first undershoot but then overshoot the quasi-steady value. ??Slow?? response of turbulence as well as flow inertia is responsible for these behaviours. In the ramp-up flow, the response of turbulence is similar to that observed in uniformly accelerating flows from previous studies, exhibiting a three-stage development. However, the transition between the various stages is more gradual and the responding stage is much longer and slower in the flows considered here. It has been shown that the delay in the near wall region is longer than that in the buffer layer confirming that turbulence response first occurs at the location of peak turbulence production. In a strongly decelerating flow, the response of turbulence exhibits a two-stage development. In both ramp-up and ramp down flows, the energy distribution in the three components of turbulent kinetic energy deviates from that of the steady flow. In a ramp-up flow, more energy is in $u_1^\prime $ and less in $u_2^\prime $ and $u_3^\prime $ , whereas the trend is reversed in a ramp-down flow. This is a reflection of the redistribution of turbulence from $u_1^\prime $ to $u_2^\prime $ and $u_3^\prime $ .     

Chiral Gay–Berne model for molecular dynamics computer simulations

Abstract

We have extended the chiral Gay–Berne (GB) pair potential of Memmer and co–workers [Liq. Cryst. (15), 345 (1993)] to the general case of biaxial ellipsoids, and we provide explicit expressions for the gradient and the torques to be used in molecular dynamics (MD) codes. To test our results against published results we have performed MD simulations of samples formed by N?=?1024 uniaxial GB ellipsoids with constant volume, and we have studied how the thermotropic behavior is affected by particle chirality. We have run temperature scans starting from isotropic samples and found clear signatures of the spontaneous formation of both lower temperature blue and cholesteric phases.     

Chaos in free electron laser oscillators

The chaotic nature of a storage-ring free electron laser (FEL) is investigated. The derivation of a low embedding dimension for the dynamics allows the low-dimensionality of this complex system to be observed, whereas its unpredictability is demonstrated, in some ranges of parameters, by a positive Lyapounov exponent. The route to chaos is then explored by tuning a single control parameter, and a period-doubling cascade is evidenced, as well as intermittence.     

Search of the neutrino-less double beta decay of $$^{}$$Se into the excited states of $$^{}$$Kr with CUPID-0

The CUPID-0 experiment searches for double beta decay using cryogenic calorimeters with double (heat and light) read-out. The detector, consisting of 24 ZnSe crystals 95\(\%\) enriched in \(^{82}\)Se and two natural ZnSe crystals, started data-taking in 2017 at Laboratori Nazionali del Gran Sasso. We present the search for the neutrino-less double beta decay of \(^{82}\)Se into the 0\(_1^+\), 2\(_1^+\) and 2\(_2^+\) excited states of \(^{82}\)Kr with an exposure of 5.74 kg\(\cdot \)yr (2.24\(\times \)10\(^{25}\) emitters\(\cdot \)yr). We found no evidence of the decays and set the most stringent limits on the widths of these processes: \(\varGamma \)(\(^{82}\)Se \(\rightarrow ^{82}\)Kr\(_{0_1^+}\))8.55\(\times \)10\(^{-24}\) yr\(^{-1}\), \(\varGamma \) (\(^{82}\) Se \(\rightarrow ^{82}\) Kr \(_{2_1^+}\))\(\,{<}\,6.25 \,{\times }\,10^{-24}\) yr\(^{-1}\), \(\varGamma \)(\(^{82}\)Se \(\rightarrow ^{82}\)Kr\(_{2_2^+}\))8.25\(\times \)10\(^{-24}\) yr\(^{-1}\) (90\(\%\) credible interval).     

Phase Transition in the 1d Random Field Ising Model with Long Range Interaction

We study one–dimensional Ising spin systems with ferromagnetic, long–range interaction decaying as n ^−2+α , , in the presence of external random fields. We assume that the random fields are given by a collection of symmetric, independent, identically distributed real random variables, gaussian or subgaussian. We show, for temperature and strength of the randomness (variance) small enough, with IP = 1 with respect to the random fields, that there are at least two distinct extremal Gibbs measures. Supported by: GDRE 224 GREFI-MEFI, CNRS-INdAM. P.P was also partially supported by INdAM program Professori Visitatori 2007; M.C and E.O were partially supported by Prin07: 20078XYHYS.     

Identification of zones in a free evolving vortex ring

A direct numerical simulation of a three-dimensional free evolving vortex ring has been performed to understand some features of the dynamics of vortex rings. In previous experiments, a persistent wake has been observed and the direct simulation has clarified the causes of this wake formation. A kinematic alignment analysis of the vorticity vector with the eigenvectors of the strain-rate tensor, together with vorticity visualisations, have been employed to explain the growth of the Widnall instabilities. The analysis has shown the presence of two different zones, the first characterised by intense vorticity and low strain rate and the second with opposite features. In the former, there is a ring core which maintains its coherence even in the long term, in the latter there are elongated structures contributing to the deformation of the ring.