Evaluation of the decay in temporal coherence of a laser beam propagating in a slowly fluctuating medium

A simple method is described for evaluating the change in temporal coherence which occurs when a monochromatic light wave traverses a medium the properties of which fluctuate randomly. The degree of second-order coherence is formulated in terms of the amplitude and phase autocorrelation functions which are derived from the photocurrent produced in a light beating experiment. This method makes it possible to evaluate even a small deterioration in temporal coherence which is closely related to the frequency fluctuations in the light wave. The change in temporal coherence of a laser beam propagating through a slowly fluctuating gaseous path has been measured.     

(1R,2R,3S,4S)‐2‐[(2R,3S)‐2,3‐Di­methyl­oxiran‐2‐yl]‐3,4‐bis(4‐methoxy­benzyl­oxy)­cyclo­hexanol

The relative configuration was determined for the title com­pound, C₂₆H₃₄O₆, which was prepared in a synthetic study on immunosuppressant FR­65­814. There is an intra­mol­ecular hydrogen bond between the hydroxy and epoxy groups.     

Nonstationary Vibrations of a String with Time-Varying Length and a Mass-Spring Attached at the Lower End

The purpose of this paper is to study the nonstationary vibration of a string with time-varying length and a mass-spring system attached at the lower end. The string is hung vertically and excited sinusoidally by a horizontal displacement at its upper end. The mass is supported by a guide spring horizontally and has two-degrees-of-freedom, vertical and horizontal. It is shown analytically that axial velocity of the string influences the peak amplitude of the string vibration at the passage through resonances. Moreover, it is shown numerically that the amplitudes of both the string and the mass vibrations depend on the sign of the axial velocity, when the natural frequency of the mass-spring system is close to the frequency of the excitation. The above two theoretical results are confirmed experimentally with a simple experimental setup.     

Selective and Nonselective Cleavages in Positive and Negative CID of the Fragments Generated from In-Source Decay of Intact Proteins in MALDI-MS

Selective and nonselective cleavages in ion trap low-energy collision-induced dissociation (CID) experiments of the fragments generated from in-source decay (ISD) with matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) of intact proteins are described in both positive and negative ion modes. The MALDI-ISD spectra of the proteins demonstrate common, discontinuous, abundant c- and z′-ions originating from cleavage at the N–Cα bond of Xxx-Asp/Asn and Gly-Xxx residues in both positive- and negative-ion modes. The positive ion CID of the c- and z′-ions resulted in product ions originating from selective cleavage at Asp-Xxx, Glu-Xxx and Cys-Xxx residues. Nonselective cleavage product ions rationalized by the mechanism of a “mobile proton” are also observed in positive ion CID spectra. Negative ion CID of the ISD fragments results in complex product ions accompanied by the loss of neutrals from b-, c-, and y-ions. The most characteristic feature of negative ion CID is selective cleavage of the peptide bonds of acidic residues, Xxx-Asp/Glu/Cys. A definite influence of α-helix on the CID product ions was not obtained. However, the results from positive ion and negative ion CID of the MALDI-ISD fragments that may have long α-helical domains suggest that acidic residues in helix-free regions tend to degrade more than those in helical regions.

Lewis Acid Mediated Addition of Tri-n-Butylstannylmethylisoxazole with Aldehydes

Lewis acid mediated addition of 5-(tri-n-butylstannyl)methyl-3-methylisoxazole and its analogues with aldehydes have been carried out. Corresponding 5-(β-hydroxy)ethylisoxazoles were obtained in moderate yields, without ring opening of the isoxazole.