NMR studies of uranyl benzenesulfonate solvation and phase diagram of uranyl benzenesulfonate-water-tributyl phosphate system

Uranyl hydration and solvation numbers of uranyl benzenesulfonate (BSU) aqueous-organic solutions have been determined by means of dynamic NMR spectroscopy technique. Three aqua-complexes have been found to exist in aqueous-acetone solution: [UO₂ (U₆H₅SO₃)₂·4H₂O] and [UO₂(C₆H₅SO₃)₂·(H₂O)_n] where n=1 or 2 and anions are bridging bidentate. Transition from [UO₂ (C₆H₅SO₃)₂·4H₂O] to the higher aqua complexes begins at P>40. There is a disolvate in the non-aqueous solution of BSU in tri-n-butyl phosphate (TBP). Composition of aqueous and organic phase of the BSU-water-TBP ternary system has been determined at room temperature, allowing to produce the phase diagram of the system. The binodale position is related to the anion amphiphilicity. The solvation number determined for BSU in the organic phases corresponds exactly to the low temperature data and allows to observe BSU dehydration and desolvation in the region of mutual dissolution of water and the organic phase, as well as TBP and the aqueous phase.     

Role of phosphates in the promotion of silver catalysts for partial oxidation: I. Structure and properties of phosphates on the surface of polycrystalline silver

The chemical composition, structure, and properties of an H₃PO₄-promoted polycrystalline silver foil are studied by XPS. The surface of the doped sample contains oxygen in two states with binding energies of 531.1 and 533.0 eV. Heat treatment results in silver clusters distributed in the polyphosphate matrix. It follows from TDS data that the surface of the promoted catalyst contains a strongly bound oxygen species that desorbs at ~900 K. It is believed that the silver clusters stabilized by the phosphate matrix are active sites on the surface of the phosphorus-promoted catalyst.Translated from Kinetika i Kataliz, Vol. 46, No. 1, 2005, pp. 153–160. Original Russian Text Copyright © 2005 by Knyazev, Boronin, Vodyankina, Koshcheev, Kurina.     

The practical synthesis of a novel and highly potent analogue of bryostatin

Macrocycle 1 is a new highly potent analogue of bryostatin 1, a promising anti-cancer agent currently in human clinical trials. In vitro, 1 displays picomolar affinity for PKC and exhibits over 100-fold greater potency than bryostatin 1 when tested against various human cancer cell lines. Macrocycle 1 can be generated in clinically required amounts by chemical synthesis in only 19 steps (LLS) and represents a new clinical lead for the treatment of cancer.     

Structural studies on layered alkylpyridinium iodopalladate networks

The reaction of alkylpyridinium (CnH2n + 1NC5H5, hereafter Cn-Py) iodide salts in aqueous acetonitrile with a preformed palladium iodide precursor afforded two different types of organic-inorganic phases depending on the molar ratio. A 2:1 ratio yielded the phase [Cn-Py]2[PdI4] (3, n = 14, 16), which crystallized in the triclinic crystal system. The X-ray crystal structure of 3, (n = 14), refined in the space group P1 (a = 8.918(3) A, b = 9.894(3) A, c = 29.062(12) A, alpha = 93.51(3) degrees, beta = 94.17(3) degrees, gamma = 115.60(3) degrees, and Z = 2), consists of interdigitated bilayers with a basal spacing of 29.0 A. The aliphatic chains of the cations, which run almost parallel to the stacking direction, are fully stretched between polar planes built on isolated [PdI4]2- anions and cation headgroups. Changing the organic cation to palladium ratio to 1:1 led to a new phase [Cn-Py]2[Pd2I6] (4, n = 14, 16), which crystallizes in the triclinic P1 space group (a = 9.399(4) A, b = 14.264(6) A, c = 29.415(13) A, alpha = 92.11(4) degrees, beta = 90.07(4) degrees, gamma = 104.53(3) degrees, Z = 3 for 4(n = 14); a = 9.417(2) A, b = 14.215(3) A, c = 31.552(6) A, alpha = 87.96(3) degrees, beta = 87.63(3) degrees, gamma = 75.67(3) degrees, Z = 3 for 4(n = 16)). The layered structure is basically of a continuously interdigitated single-layer type, with a bilayer sublattice superimposed. Isolated [Pd2I6]2- anions contribute to the inorganic planes. A high degree of interdigitation and tilting of the aliphatic chains lead to basal spacings of 29.4 and 31.5 A for 4(n = 14) and 4(n = 16), respectively. The [Cn-Py]2[PdI4] and [Cn-Py]2[Pd2I6] phases were characterized by thermal analysis. Mesomorphic behavior was observed only for 3(n = 16), which was confirmed by variable-temperature powder XRD and optical microscopy.     

Cystic fibrosis proteins detected by electrophoretic techniques

For the detection of the cystic fibrosis protein (CFP) in serum of cystic fibrosis (CF) carriers, thin-layer polyacrylamide gel isoelectric focusing proved inappropriate as a diagnostic test, but was useful for screening fractions on purification of CFP by chromatofocusing on a Mono P column. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis an Mr 12,000 protein (P12) was found in most CFP-positive sera, indicating good correlation between these two CF-associated proteins. Detection of the P12 protein by sodium dodecyl sulfate-polyacrylamide gel electrophoresis was well reproducible and less delicate than IEF. The technique was also used to purify P12 from serum by two successive preparative electrophoresis steps in a 7.5-15% gradient and 15% homogeneous gel. The use of silver staining revealed that P12, which was present in all sera of CF patients and carriers with variable intensities, was also present in trace amounts in normal sera.     

The synthesis of cis- and trans-1,2-dibromocyclopropane

A preparative route to cis- and trans-1,2-dibromocyclopropane ($\text{1}$) was developed via the Hunsdiecker reaction of silver cyclopropane-1,2-dicarboxylate ($\text{2}$). Cis- and trans-$\text{2}$ gave the same ratio of cis- and trans-$\text{1}$ (1:3.2). The mechanism of this reaction is briefly discussed.     

Determination of lead in the urine of exposed and unexposed adults by extraction and flow-injection/atomic absorption spectrometry

Lead is extracted from urine with ammonium pyrrolidien dithiocrbamate into methyl isobutyl ketone, and 20 μl of the extract is injected into a water carrier stream in a flow-injection/atomic absorption system. The procedure is simple, quick, accurate and reproducible. Recoveries are 96–105%. The mean urine lead contents of 20 unexposed and 20 printing-press lead exposed workers was found to be 39.0 ± 8.3 and 71.7 ± 26.3 μg Pb l^?1, respectively.     

The preparation of polysiloxane xerogels containing amide derivatives of phosphonic and thiophosphonic acids in the surface layer

Xerogels containing residues of amide derivatives of phosphonic and thiophosphonic acids, ≡Si(CH₂)₃NHP(S, O)(OC₂H₅)₂ (functional group concentration of 1.3–2.2 mmol/g) have been prepared by a sol-gel method. It has been shown that xerogels having a developed porous structure (with specific surface areas of 240–485 m²/g, pore volumes of 0.20–0.50 cm³/g, and pore diameters of 3.6–6.5 nm) are formed at tetraethoxysilane-to-trifunctional silane ratios of 4: 1 (and above) and 6: 1 (and above) for the derivatives of phosphonic and thiophosphonic acids, respectively. The IR and ¹³C CP/MAS NMR spectroscopy data have demonstrated that the surface layer of the xerogels contains not only (thio)phosphonic acid residues, but also silanol groups and water molecules participating in hydrogen bonding. The ²⁹Si CP/MAS NMR spectroscopy data have indicated that structural groups are, for the most part, contained in structural units T³ [(≡SiO)₃Si(CH₂)₃NHP(O, S)(OC₂H₅)₂] and T² [(≡SiO)₂Si(OR)[(CH₂)₃NHP(O, S)(OC₂H₅)₂] (R = H or C₂H₅).     

Synthesis of 4-Formyl-3-cyclopentene-1,1,2-tricarbonitriles

β,β,γ,γ-Tetracyanoalkanones react with acrolein at a high rate to afford the corresponding 2-substituted 4-formyl-3-cyclopentene-1,1,2-tricarbonitriles in high yields. The reaction occurs under mild conditions and is quite applicable for modification of natural and biologically active compounds possessing an R′CHC(O)CR₃ fragment to obtain their derivatives containing three cyano groups.