A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent

A new taxoid, 5alpha,13alpha-diacetoxy-10beta-cinnamoyloxy-4(20),11-taxadien-9alpha-ol (1) along with its 9,10-isomer, taxinine NN-11 (2) were isolated from the callus cultures of Taxus cuspidata. The structures were identified by the analyses of the spectral data and chemical method. Their in vitro cytotoxicity against 3 cell lines (HepG2, WI-38 and VA-13) and multidrug resistance (MDR) reversal activity toward 2780AD tumor cells were preliminarily evaluated, the low cytotoxicities and potent MDR reversal activities suggested that they might be good lead compounds of tumor MDR reversal agent.     

Lawvere theories enriched over a general base

We generalise the correspondence between Lawvere theories and finitary monads on in two ways. First, we allow our theories to be enriched in a category V that is locally finitely presentable as a symmetric monoidal closed category: symmetry is convenient but not necessary. And second, we allow the arities of our theories to be finitely presentable objects of a locally finitely presentable V-category A. We call the resulting notion that of a Lawvere A-theory. We extend the correspondence for ordinary Lawvere theories to one between Lawvere A-theories and finitary V-monads on A. We illustrate this with examples leading up to that of the Lawvere -theory for cartesian closed categories, i.e., the -enriched theory on the category for which the models are all small cartesian closed categories. We also briefly investigate change-of-base.     

Analysis of SiC crystal sublimation growth by fully coupled compressible multi-phase flow simulation

A fully coupled compressible multi-phase flow solver was developed to effectively design a large furnace for producing large-size SiC crystals. Compressible effect, convection and buoyancy effects, flow coupling between argon gas and species, and the Stefan effect are included. A small and experimental furnace is used to validate the solver. First, the essentiality of 2D flow calculation and the significance of incorporating buoyancy effect and gas convection, the Stefan effect, and flow interaction between argon gas and species were investigated by numerical results. Then the effects of argon gas on deposition rate, growth rate, graphitization on the powder source, and supersaturation and stoichiometry on the seed were analyzed. Finally, the advantages of an extra chamber design were explained, and improvement of growth rate was validated by the present solver.