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221.
Creaven BS Czeglédi E Devereux M Enyedy ÉA Foltyn-Arfa Kia A Karcz D Kellett A McClean S Nagy NV Noble A Rockenbauer A Szabó-Plánka T Walsh M 《Dalton transactions (Cambridge, England : 2003)》2010,39(45):10854-10865
The coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands, which had previously shown good anti-Candida activity, were investigated by pH-potentiometric and UV-Vis spectroscopic methods. These studies confirmed the coordination mode of the ligands to be through the N of the imine and deprotonated phenol of the coumarin-derived ligand in solution. In addition, the more active complexes and their corresponding ligands were investigated in the presence of copper(II) in liquid and frozen solution by ESR spectroscopic methods. A series of secondary amine derivatives of the Schiff base ligands, were isolated with good solubility characteristics but showed little anti-Candida activity. However, cytotoxicity studies of the secondary amines, together with the copper complexes and their corresponding ligands, against human colon cancer and human breast cancer cells identified the chemotherapeutic potential of these new ligands. 相似文献
222.
Dr. Raffael Davenport Dr. Mattia Silvi Dr. Adam Noble Dr. Zied Hosni Dr. Natalie Fey Prof. Dr. Varinder K. Aggarwal 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(16):6587-6590
There are a limited number of ring-contraction methodologies which convert readily available five-membered rings into strained four-membered rings. Here we report a photo-induced radical-mediated ring contraction of five-membered-ring alkenyl boronate complexes into cyclobutanes. The process involves the addition of an electrophilic radical to the electron-rich alkenyl boronate complex, leading to an α-boryl radical. Upon one-electron oxidation, ring-contractive 1,2-metalate rearrangement occurs to give a cyclobutyl boronic ester. A range of radical precursors and vinyl boronates can be employed, and chiral cyclobutanes can be accessed with high levels of stereocontrol. The process was extended to the preparation of benzofused cyclobutenes and the versatility of the boronic ester was demonstrated by conversion to other functional groups. 相似文献
223.
Jonathan Tennyson C. J. Noble P. G. Burke 《International journal of quantum chemistry》1986,29(5):1033-1042
The interaction of low-energy electrons with H and ligh with H2 is analyzed using the R-matrix method including both coupled state and polarization effects ab initio. Particular attention is paid to the energy region containing low-lying H*2 resonances which converge to H A 2Σ. Resonances in both elastic scattering and the photoionization asymmetry parameter, β, are presented. At low photon eneries, satisfactory results for vibrationally resolved photoionization are obtained using the adiabatic nuclei approximation. The use of nonadiabatic techniques for higher energies is discussed. 相似文献
224.
A one‐pot reaction of ninhydrin, N‐methyl‐C‐phenyl nitrone, and secondary amine leading to the unprecedented synthesis of 3,3‐disubstituted isochroman‐1,4‐diones is described here. In this reaction, nitrone acts as an oxygen atom donor producing an imine as a side product. The mild reaction conditions, the flexibility of the secondary amines that can be used, the novelty of the product, and the good yields are the highlights of this reaction. 相似文献
225.
Beln Rubial Beatrice S. L. Collins Raphael Bigler Stefan Aichhorn Adam Noble Varinder K. Aggarwal 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(5):1380-1384
The one‐pot sequential coupling of benzylamines, boronic esters, and aryl iodides has been investigated. In the presence of an N‐activator, the boronate complex formed from an ortho‐lithiated benzylamine and a boronic ester undergoes stereospecific 1,2‐metalate rearrangement/anti‐SN2′ elimination to form a dearomatized tertiary boronic ester. Treatment with an aryl iodide under palladium catalysis leads to rearomatizing γ‐selective allylic Suzuki–Miyaura cross‐coupling to generate 1,1‐diarylalkanes. When enantioenriched α‐substituted benzylamines are employed, the corresponding 1,1‐diarylalkanes are formed with high stereospecificity. 相似文献
226.
Dr. Yahui Wang Dr. Adam Noble Dr. Eddie L. Myers Prof. Dr. Varinder K. Aggarwal 《Angewandte Chemie (International ed. in English)》2016,55(13):4270-4274
Enantioenriched secondary and tertiary alkyl pinacolboronic esters undergo enantiospecific deborylative alkynylation through a Zweifel‐type alkenylation followed by a 1,2‐elimination reaction. The process involves use of α‐lithio vinyl bromide or vinyl carbamate species, for which application to Zweifel‐type reactions has not previously been explored. The resulting functionalized 1,1‐disubstituted alkenes undergo facile base‐mediated elimination to generate terminal alkyne products in high yield and excellent levels of enantiospecificity over a wide range of pinacolboronic ester substrates. Furthermore, along with terminal alkynes, internal and silyl‐protected alkynes can be formed by simply introducing a suitable carbon‐ or silicon‐based electrophile after the base‐mediated 1,2‐elimination reaction. 相似文献
227.
P N Floriano C O Noble J M Schoonmaker E D Poliakoff R L McCarley 《Journal of the American Chemical Society》2001,123(43):10545-10553
A family of diaminobutane core, poly(propylene imine) dendrimers coordinated to Cu(II), DAB-Am(n)-Cu(II)x (n = 4, 8, 16, 32, 64, x = n/2), was studied by means of extended X-ray absorption fine structure (EXAFS) and X-ray absorption near-edge structure (XANES) spectroscopies. The geometry of the dipropylene triamine (dpt)-Cu(II) end-group complexes for all dendrimer generations is reported for the first time and is found to be that of a square-based pyramid with each Cu ion bound to three nitrogen atoms (Cu-N distance approximately 2.03 A) of the dpt end group of the dendrimer. An oxygen atom residing 1.96 A from the Cu ion also occupies the equatorial plane, and the pyramid is completed by an axial oxygen at approximately 2.65 A. In addition, we report for the first time that reduction of the Cu(II)-dendrimer complexes with NaBH4 yields DAB-Am(n)-Cu(0)(cluster) species. Transmission electron microscopy (TEM) studies of the reduced species demonstrate that there is a systematic decrease in the size of the generated Cu clusters with increasing dendrimer generation. Additionally, it was found that the size of the nanoclusters is a function of the n/x ratio of the DAB-Am(n)-Cu(II)x precursor, with highly monodisperse, extremely small nanoclusters (r(cluster) = 8.0 +/- 1.6 A) obtained with n = 64 and x = 16. EXAFS and XANES measurements on the reduced DAB-Am(n)-Cu(0)(cluster) corroborate the TEM data, and provide additional information on the possible encapsulation of the Cu nanoclusters by the dendrimers. 相似文献
228.
The synthesis of two deoxyoligonucleotides, d(G-T-G-A-G-T-T-A-G-C-T-C-A-C) and d(G-T-G-A-G-C-T-A-A-C-T-C-A-C), corresponding to the DNA binding site for cyclic AMP receptor protein is reported. These syntheses have been completed in milligram quantities using a silica gel polymer support methodology and mononucleotide phosphoramidites. Procedures are also reported for synthesizing diastereoisomers of dinucleoside methylphosphonate 3phosphoramidites. 相似文献
229.
230.
We consider the equivalence classes of graphs induced by the unsigned versions of the Reidemeister moves on knot diagrams. Any graph that is reducible by some finite sequence of these moves, to a graph with no edges, is called a knot graph. We show that the class of knot graphs strictly contains the set of delta‐wye graphs. We prove that the dimension of the intersection of the cycle and cocycle spaces is an effective numerical invariant of these classes. © 2000 John Wiley & Sons, Inc. J Graph Theory 34: 100–111, 2000 相似文献