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991.
Alkaline hydrolysis of high-molecular-mass (10 MDa) linear polyacrylamide, a widely used replaceable sieving medium for the capillary electrophoresis of DNA fragments and proteins, was investigated. The release rate of ammonia, a product of amide group hydrolysis, was monitored by a high-sensitivity continuous-flow system. The experimental results show a rapid onset of hydrolysis at a temperature of 70 degrees C. While the degree of 1 h hydrolysis was evaluated to reach about 16% at 70 degrees C and pH 13, it drops to 5% at 50 degrees C and pH 12.5. 相似文献
992.
993.
994.
Theoretical Studies on the Intermolecular Interactions of Potentially Primordial Base‐Pair Analogues
Judit E. Šponer Dr. Álvaro Vázquez‐Mayagoitia Dr. Bobby G. Sumpter Dr. Jerzy Leszczynski Prof. Jiří Šponer Prof. Michal Otyepka Dr. Pavel Banáš Dr. Miguel Fuentes‐Cabrera Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(10):3057-3065
Recent experimental studies on the Watson–Crick type base pairing of triazine and aminopyrimidine derivatives suggest that acid/base properties of the constituent bases might be related to the duplex stabilities measured in solution. Herein we use high‐level quantum chemical calculations and molecular dynamics simulations to evaluate the base pairing and stacking interactions of seven selected base pairs, which are common in that they are stabilized by two N? H???O hydrogen bonds separated by one N? H???N hydrogen bond. We show that neither the base pairing nor the base stacking interaction energies correlate with the reported pKa data of the bases and the melting points of the duplexes. This suggests that the experimentally observed correlation between the melting point data of the duplexes and the pKa values of the constituent bases is not rooted in the intrinsic base pairing and stacking properties. The physical chemistry origin of the observed experimental correlation thus remains unexplained and requires further investigations. In addition, since our calculations are carried out with extrapolation to the complete basis set of atomic orbitals and with inclusion of higher electron correlation effects, they provide reference data for stacking and base pairing energies of non‐natural bases. 相似文献
995.
A study of LA-ICP-MS analysis of pressed powdered tungsten carbide precursors was performed to show the advantages and problems of nanosecond laser ablation of matrix-unified samples. Five samples with different compositions were pressed into pellets both with silver powder as a binder serving to keep the matrix unified, and without any binder. The laser ablation was performed by nanosecond Nd:YAG laser working at 213 nm.The particle formation during ablation of both sets of pellets was studied using an optical aerosol spectrometer allowing the measurement of particle concentration in two size ranges (10-250 nm and 0.25-17 μm) and particle size distribution in the range of 0.25-17 μm. Additionally, the structure of the laser-generated particles was studied after their collection on a filter using a scanning electron microscope (SEM) and the particle chemical composition was determined by an energy dispersive X-ray spectroscope (EDS).The matrix effect was proved to be reduced using the same silver powdered binder for pellet preparation in the case of the laser ablation of powdered materials.The LA-ICP-MS signal dependence on the element content present in the material showed an improved correlation for Co, Ti, Ta and Nb of the matrix-unified samples compared to the non-matrix-unified pellets. In the case of W, the ICP-MS signal of matrix-unified pellets was influenced by the changes in the particle formation. 相似文献
996.
Ali H. Eltmimi Leon Barron Aran Rafferty John P. Hanrahan Olga Fedyanina Ekaterina Nesterenko Pavel N. Nesterenko Brett Paull 《Journal of separation science》2010,33(9):1231-1243
A range of porous carbon‐based monolithic (PCM) rods with flow‐through pore sizes of 1, 2, 5 and 10 μm, were produced using a silica particle template method. The rods were characterised using SEM and energy‐dispersive X‐ray spectroscopy, BET surface area and porous structure analysis, dilatometry and thermal gravimetry. SEM evaluation of the carbon monolithic structures revealed an interconnected rigid bimodal porous structure and energy‐dispersive X‐ray spectroscopy analysis verified the quantitative removal of the embedded silica beads. The specific surface areas of the 1, 2, 5 and 10 μm rods were 178, 154, 84 and 125 m2/g after pyrolysis and silica removal, respectively. Shrinkage of the monolithic rods during pyrolysis is proportional to the particle size of the silica used and ranged from 9 to 12%. Mercury porosimetry showed a narrow distribution of pore sizes, with an average of ~700 nm for the 1 μm carbon monolith. The suitability of bare and surface oxidised PCM rods for the use as a stationary phase for reversed and normal phase LC was explored. The additional modification of PCM rods with gold micro‐particles followed by 6‐mercaptohexanoic acid was performed and ion‐exchange properties were evaluated. 相似文献
997.
Sichula V Kucheryavy P Khatmullin R Hu Y Mirzakulova E Vyas S Manzer SF Hadad CM Glusac KD 《The journal of physical chemistry. A》2010,114(46):12138-12147
We investigated the electronic properties of N(5)-ethyl flavinium perchlorate (Et-Fl(+)) and compared them to those of its parent compound, 3-methyllumiflavin (Fl). Absorption and fluorescence spectra of Fl and Et-Fl(+) exhibit similar spectral features, but the absorption energy of Et-Fl(+) is substantially lower than that of Fl. We calculated the absorption signatures of Fl and Et-Fl(+) using time-dependent density functional theory (TD-DFT) methods and found that the main absorption bands of Fl and Et-Fl(+) are (π,π*) transitions for the S(1) and S(3) excited states. Furthermore, calculations predict that the S(2) state has (n,π*) character. Using cyclic voltammetry and a simplistic consideration of the orbital energies, we compared the HOMO/LUMO energies of Fl and Et-Fl(+). We found that both HOMO and LUMO orbitals of Et-Fl(+) are stabilized relative to those in Fl, although the stabilization of the LUMO level was more pronounced. Visible and mid-IR pump-probe experiments demonstrate that Et-Fl(+) exhibits a shorter excited-state lifetime (590 ps) relative to that of Fl (several nanoseconds), possibly due to faster thermal deactivation in Et-Fl(+), as dictated by the energy gap law. Furthermore, we observed a fast (23-30 ps) S(2) → S(0) internal conversion in transient absorption spectra of both Fl and Et-Fl(+) in experiments that utilized pump excitations with higher energy. 相似文献
998.
Gabriela Broncová Sergey Anikin Ulrich Lange Pavel Matějka Martin Krondak Vladimír Král Vladimir M. Mirsky 《Journal of Solid State Electrochemistry》2010,14(6):1035-1044
The structure and the electrochemical and spectral properties of two conductive electrochemically polymerized substituted
bipyrroles 4,4′-methoxy-2,2′-bipyrrole and 4,4′-buthoxy-2,2′-bipyrrole were studied and compared. The polymers were characterized
by cyclic voltammetry, FT-Raman spectroscopy, scanning electron microscopy, and in situ conductivity measurements at different
pH and redox state. 相似文献
999.
1000.
Francesco Aquilante Luca De Vico Nicolas Ferr Giovanni Ghigo Per‐ke Malmqvist Pavel Neogrdy Thomas Bondo Pedersen Michal Pitok Markus Reiher Bjrn O. Roos Luis Serrano‐Andrs Miroslav Urban Valera Veryazov Roland Lindh 《Journal of computational chemistry》2010,31(1):224-247
Some of the new unique features of the MOLCAS quantum chemistry package version 7 are presented in this report. In particular, the Cholesky decomposition method applied to some quantum chemical methods is described. This approach is used both in the context of a straight forward approximation of the two‐electron integrals and in the generation of so‐called auxiliary basis sets. The article describes how the method is implemented for most known wave functions models: self‐consistent field, density functional theory, 2nd order perturbation theory, complete‐active space self‐consistent field multiconfigurational reference 2nd order perturbation theory, and coupled‐cluster methods. The report further elaborates on the implementation of a restricted‐active space self‐consistent field reference function in conjunction with 2nd order perturbation theory. The average atomic natural orbital basis for relativistic calculations, covering the whole periodic table, are described and associated unique properties are demonstrated. Furthermore, the use of the arbitrary order Douglas‐Kroll‐Hess transformation for one‐component relativistic calculations and its implementation are discussed. This section especially focuses on the implementation of the so‐called picture‐change‐free atomic orbital property integrals. Moreover, the ElectroStatic Potential Fitted scheme, a version of a quantum mechanics/molecular mechanics hybrid method implemented in MOLCAS, is described and discussed. Finally, the report discusses the use of the MOLCAS package for advanced studies of photo chemical phenomena and the usefulness of the algorithms for constrained geometry optimization in MOLCAS in association with such studies. © 2009 Wiley Periodicals, Inc. J Comput Chem 2010 相似文献