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461.
Abraham E Brock EA Candela-Lena JI Davies SG Georgiou M Nicholson RL Perkins JH Roberts PM Russell AJ Sánchez-Fernández EM Scott PM Smith AD Thomson JE 《Organic & biomolecular chemistry》2008,6(9):1665-1673
The highly diastereoselective anti-aminohydroxylation of (E)-gamma-tri-iso-propylsilyloxy-alpha,beta-unsaturated esters, via conjugate addition of lithium (S)-N-benzyl-N-(alpha-methylbenzyl)amide and subsequent in situ enolate oxidation with (+)-(camphorsulfonyl)oxaziridine, has been used as the key step in the asymmetric synthesis of N,O,O,O-tetra-acetyl d-lyxo-phytosphingosine (20% yield over 7 steps), the anhydrophytosphingosine jaspine B (10% yield over 9 steps), 2-epi-jaspine B (14% yield over 9 steps), and the Prosopis alkaloid deoxoprosophylline (26% yield over 7 steps). 相似文献
462.
463.
The title compound was prepared from the (p-cymene)ruthenium chloride dimer and thioglycollic acid. The structure is a centrosymmetric dimer bridged by the soft-base S atoms, with the hard-base O atoms of the carboxylate group chelating to form a five-membered twisted-ring. The coordination of the ruthenium atoms is completed by a η6-p-cymene ligand, giving an 18-electron count. The Ru–S bonds are essentially equal at 2.396(1) Å. 相似文献
464.
Bullinger D Fux R Nicholson G Plontke S Belka C Laufer S Gleiter CH Kammerer B 《Journal of the American Society for Mass Spectrometry》2008,19(10):1500-1513
The physiological response of the human body to several diseases can be reflected by the metabolite pattern in biological
fluids. Cancer, like other diseases accompanied by metabolic disorders, causes characteristic effects on cell turnover rate,
activity of modifying enzymes, and RNA/DNA modifications. This results in an altered excretion of modified nucleosides and
biochemically related compounds. In the course of our metabolic profiling project, we screened 24-h urine of patients suffering
from lung, rectal, or head and neck cancer for previously unknown ribosylated metabolites. Therefore, we developed a sample
preparation procedure based on boronate affinity chromatography followed by additional prepurification with preparative TLC.
The isolated metabolites were analyzed by ion trap mass spectrometry (IT MS) and Fourier transform ion cyclotron resonance
mass spectrometry (FTICR MS). IT MS was applied for LC-auto MS3 screening runs and MS
n(n=4–6) syringe pump infusion experiments, yielding characteristic fragmentation patterns. FTICR MS measurements enabled the calculation
of corresponding molecular formulae based on accurate mass determination (mass accuracy: 1–5 ppm for external and sub-ppm
values for internal calibration). We were able to identify 22 metabolites deriving from cellular RNA metabolism and related
metabolic pathways like histidine metabolism, purine biosynthesis, methionine/polyamine cycle, and nicotinate/nicotinamide
metabolism. The compounds 1-ribosyl-3-hydroxypyridinium, 1-ribosyl-pyridinium, and 3-ribosyl-1-methyl-l-histidinium as well as a series of ribosylated histamines, conjugated to carboxylic acids at the Nω-position were found as novel urinary constituents. The occurrence of the modified nucleosides 2-methylthio-N
6-(cis-hydroxyisopentenyl)-adenosine, 5-methoxycarbonylmethyl-2-thiouridine, N
6-methyl-N
6-threonylcarbamoyladenosine, and 2-methylthio-N
6-threonylcarbamoyladenosine in human urine is verified for the first time. 相似文献
465.
Yeman H Nicholson TM Friebolin V Steinhauser L Matyska MT Pesek JJ Albert K 《Journal of separation science》2012,35(13):1582-1588
Three different cholesterol-based stationary phases were investigated with respect to their time-dependent separation behavior. The examined stationary phases differ in the used spacer molecule and the synthesis route and were used under routine laboratory conditions over a period of two years. The chromatographic behavior of the three phases was determined by using a standard reference material in addition to a separation of a steroid mixture. The surface chemistry and the modification of these with the chemically bonded moiety were investigated with nuclear magnetic resonance (NMR) spectroscopy and elemental analysis. Through applying different techniques we determined changes in retention and selectivity; solid-state NMR spectra showed changes in the surface chemistry dependent on the synthesis route. Superior long-term stability was observed for the undecanoate-cholesterol (UDC-Chol) column in terms of hydrophobic retentiveness and selectivity. 相似文献
466.
We report significant enhancement (+24 dB) of the optical beat note between a 657 nm cw laser and the second-harmonic generation of the tailored continuum at 1314 nm generated with a femtosecond Cr:forsterite laser and a nonlinear fiber Bragg grating. The same continuum is used to stabilize the carrier-envelope offset frequency of the Cr:forsterite femtosecond laser and permits improved optical stabilization of the frequency comb from 1.0 to 2.2 microm. Using a common optical reference at 657 nm, a relative fractional frequency instability of 2.0 x 10(-15) is achieved between the repetition rates of Cr:forsterite and Ti:sapphire laser systems in 10 s averaging time. The fractional frequency offset between the optically stabilized frequency combs of the Cr:forsterite and Ti:sapphire lasers is +/-(0.024 +/- 6.1) x 10(-17). 相似文献
467.
Gary J. Depree Brian K. Nicholson Nicholas P. Robinson 《Journal of organometallic chemistry》2006,691(4):667-679
The syntheses are reported of new cyclomanganated indole derivatives (1-acetyl-κO-indolyl-κC2)dicarbonylbis(trimethylphosphite)manganese (2), (1-methyl-3-acetyl-κO-indolyl-κC2)tetracarbonylmanganese (4), (3-formyl-κO-indolyl-κC2)tetracarbonylmanganese (5a) and (1-methyl-3-formyl-κO-indolyl-κC2)tetracarbonylmanganese (5b). The unusually complicated crystal structure of 5b has been determined, the first for a cyclomanganated aryl aldehyde.The preparations of a mitomycin-related pyrrolo-indole and related products by thermally promoted and oxidatively (Me3NO) initiated alkyne-coupling reactions of the previously known complex (1-acetyl-κO-indolyl-κC2)tetracarbonylmanganese (1) are reported for different alkynes and solvents. X-ray crystal structures are reported for the dimethyl acetylenedicarboxylate coupling product of 1 (dimethyl 1-methyl-l-hydroxypyrrolo[1,2a]-indole-2,3-dicarboxylate; 6a), and an unusually-cyclised triple insertion product 8 from the coupling of acetylene with 4, in which a cyclopentadiene moiety is η3-allyl-coordinated to Mn through only one double bond and an exocyclic carbon, but which rearranges on heating to an η5-cyclopentadienyl complex. 相似文献
468.
Semi‐automated thermodynamic and phase diagram calculations based on DFT and grand canonical linear programming (GCLP) methods are used to screen 102 ternary and quaternary complex transition metal hydrides (CTMHs) and 26 ternary saline hydrides in a library of over 260 metals, intermetallics, binary, and higher hydrides to identify materials that release H2 at higher temperatures than the associated binary hydrides and at elevated temperatures (T < 1000 K, 1 bar H2 overpressure). 相似文献