Studying Systematic Errors on Estimation Decision, Detection, and Quantification Limit on Micro-TLC

The decision limit (CCα), capability of detection (CCβ) and quantification limit (QL) are importance performance characteristics in method validation. The TLC-Scanner 3 from Camag provides the possibility to choose the slit dimension of light to determine the peak chromatogram of a substance. The influence of the slit dimension for determination of CCα, CCβ and QL of paracetamol has been carried out. Paracetamol was spotted onto plates of AL-TLC Si G 60 F254 by linomat 4 in the range of 50–400 ng/spot and 10–400 ng/band, then on twin chambers eluted with TAEA (toluene:acetone-ethanol:conc.ammonia, 45 + 45 + 7 + 3 v/v) for 45 mm. Eluted spots were scanned in different slit dimensions at 248 nm. The CCα, CCβ and QL of paracetamol were estimated through the linear regression (LRM) and signal-to-noise (S/N) methods. Slit lengths between 50 and 133 % of the band width of the spots, and with the noise factor of the slit under 2.6, produced good precision measurements of TLC-densitometry between plates, while slit lengths between 50 and 83 % of the band width of the spots introduced a higher sensitivity response of the detector. The estimated CCα, CCβ and QL were determined by how the data were collected, the analytical optical setting, and the usage method for the estimation of both validation parameters.     

Polymeric piezoelectric cantilever and tubular actuators

Electroactive polymers (EAPs) have attracted a great deal of attention in the last decade due to their unique properties that are applicable to many advanced applications. The present work aims to study the materials–property relationship of this class of materials, and thus facilitate the implementation of EAPs in more applications. The present work investigated the feasibility of adapting cantilever and tubular configurations to the polymeric piezoelectric actuators. The polarization and displacement of samples (fabricated from Poly(Vinyldene fluoride‐trifluroethylene) [P(VDF‐TrFE)] thin film) were measured under both dynamic and static driving conditions. The polarization loops for all the samples exhibit little hysteresis under weak field and the polarization changes linearly with voltage for most samples. The frequency‐dependent polarization behavior is consistent with the previous reported work. The displacements for both cantilever and tubular samples are also noted to be in agreement with the theoretical prediction. Significant displacement (1079 µm) was achieved for samples, even under weak field (60 MV/m). In summary, the results have suggested that the relationship between geometric variables and the performance is also applicable to polymeric materials. Thus, the constitutive relationship can also be applied as a guideline for designing and optimizing the polymeric actuators beyond P(VDF‐TrFE) copolymer materials. Copyright © 2009 John Wiley & Sons, Ltd.     

Synthesis, cure kinetics, and thermal properties of a novel boron–silicon hybrid polymer

A novel boron–silicon hybrid polymer (PASB) was synthesized from polycondensation between phenylboron dichloride and dichloromethylsilane with Grignard reagent. The structure of PASB was characterized using fourier transform infrared spectra, ¹H-NMR, ¹³C-NMR, and gel permeation chromatography. The curing behavior of PASB was investigated by means of non-isothermal differential scanning calorimetry and the kinetic parameters were determined by the Kissinger’s and Ozawa’s methods, respectively. The results showed that both the methods for calculating the activation energy value gave fairly close results of 104.4 and 107.7 kJ mol^?1, respectively. A reasonable curing cycle for the resin system was also established, which suggested that it was reasonable to choose a curing temperature between T _i0 (452.0 K) and T _f0 (554.0 K). These results can provide theoretical guidance reference for determining the curing of the resin system. The thermal stability of cured PASB resin was studied by means of thermogravimetric analysis under nitrogen atmosphere and the temperature of 5 % mass loss (Td₅) was 610.1 °C, the residue at 1,000 °C was 87.8 %, which showed that the cured PASB resin exhibited excellent thermal properties and made it potentially useful as high performance matrix resin and precursor for ceramics.     

Finite Groups with Few TI-Subgroups

A subgroup A of a finite group G is called a TI-subgroup if either A ∩ A ^x  = 1 or A ∩ A ^x  = A holds for all x ∈ G. In this paper, finite group all of whose meta-cyclic subgroups are TI-subgroups are classified completely. In particular, such groups are solvable.     

Nonlinear optical microscopy: Endogenous signals and exogenous probes

Nonlinear optical microscopy (NLOM) relies on nonlinear light–matter interactions to provide images from larger depths within biological structures compared to conventional confocal fluorescence microscopy. These nonlinear light–matter interactions include multiphoton excitation fluorescence (MPEF), second‐harmonic generation (SHG), coherent anti‐Stokes Raman scattering (CARS), and stimulated Raman scattering (SRS). This review discusses the theories of and instrumentation for various NLOM techniques, with a particular focus on endogenous signals and exogenous probes. These signals and probes expand the breadth of information that optical imaging can provide. We also discuss the application of NLOM in biomedical research, including tissue engineering, drug delivery and clinical diagnostics. Current technological limitations are also discussed.

     

圆截面直流道中微粒黏弹性聚焦机理研究

微粒黏弹性聚焦技术近年来受到了广泛的研究重视, 但影响粒子聚焦特性的关键参数调控机理仍不清楚. 基于此目的, 本文量化研究了圆截面直流道中非牛顿流体诱导微粒黏弹性聚焦的行为, 给出了流速和流道长度对粒子聚焦特性的调控机理. 具体而言: 首先, 对比分析不同黏度牛顿流体(水和22 wt%甘油水溶液)和非牛顿流体(8 wt%聚乙烯吡咯烷酮水溶液)中粒子横向迁移行为, 发现非牛顿流体中粒子将在弹性力主导下聚焦至流道中心区域, 而牛顿流体中粒子则在惯性升力主导下迁移形成Segré-Silberberg圆环. 其次, 量化分析粒子尺寸和驱动流速对黏弹性聚焦效果的影响, 发现随着流速的增加, 粒子聚焦效果逐渐变好并最终趋于稳定, 且大粒子较小粒子具有更好的聚焦效果. 最后, 研究粒子沿流道长度的动态聚焦过程, 推导并验证了粒子聚焦所需安全流道长度的数学模型, 发现大粒子聚焦所需安全流道长度显著短于小粒子. 上述研究结果对于提升粒子黏弹性聚焦机理和过程的理解, 实现微粒聚焦特性的灵活控制具有非常重要的意义.