A simple, rapid and selective RP-HPLC method was developed and validated for the determination of ketorolac and five piperazinylalkyl
ester prodrugs. A binary isocratic mobile phase composed of a mixture of 65:35 (v/v) 0.02 M phosphate buffer (pH 5.4) and acetonitrile was used on a C18 column (125 × 4 mm, 5 μm). The injection volume was 25 μL and the detection wavelength was 314 nm and the flow rate was 1.5 mL min−1. The method exhibited excellent linearity with R2 of no less than 0.999 and intra-assay and inter-assay precision that were less than the maximum amount allowed according
to Horwitz equation. The accuracy was found to be within the allowed ±15%. The limits of detection for the analytes were between
0.060 and 0.220 μg mL−1 and the limits of quantification were between 0.183 and 0.667 μg mL−1. This method was used successfully for the study of the solubility, stability and partition coefficients of piperazinylalkyl
ester prodrugs of ketorolac. 相似文献
Octyl nicotinate is an ester prodrug which is under development for delivery of nicotinic acid to skin for treatment and prevention of dermatological conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids. We report here an isocratic RF-LC method with water/acetonitrile (10:90, v/v) as a mobile phase, for the rapid analysis of octyl nicotinate in aqueous solutions. The method was validated in terms of linearity, precision, accuracy and mean recovery of octyl nicotinate from skin homogenate ranging from 98.8 to 102.6%. Separation and quantification of amounts as low as 0.25 μg mL?1 octyl nicotinate was accomplished. The kinetic of degradation of octyl nicotinate in aqueous solution at 310, 333, 343, and 353 K was studied. The hydrolysis rate constants for degradation of octyl nicotinate in phosphate buffer and skin homogenate were reported. This method will be effective for routine analysis of octyl nicotinate stability in different formulations in future studies. 相似文献
Journal of Thermal Analysis and Calorimetry - The free convection flow of nano fluid model is considered between two parallel plates apart a distance d and the CNTs (carbon nanotubes) are... 相似文献
Substituted bis-1,3,4-oxadiazoles 3a-1 have been synthesized from the cyclization of N,N'-diaroyl or N,N'-dialkanoyl diacyl hydrazides, in presence of phosphorus oxychloride. A11 new compounds have been identified by 1H-NMR 13C-NMR and elemental analysis. 相似文献
Polymerized ionic liquid (PIL) nanoparticles are for the first time applied as sole stabilizers in aqueous emulsion polymerization and reveal an astonishing and unexpected behavior. In a well‐dispersed state, the PIL nanoparticles serve as an unexpectedly effective stabilizer for polystyrene dispersions, enabling solids content of greater than 40%. However, the same PIL as dry powder is hydrophobic and, in accordance with Bancroft's rule, unable to stabilize aqueous dispersions. This ambivalent behavior of PIL is extremely beneficial for the application of aqueous dispersions because, as desired for decades, the hydrophilic dispersed state during synthesis turns hydrophobic in the dried state during application of the polymer.
In this work, the feedback control method is proposed to control the behaviour of Liu chaotic dynamical system. The controlled system is stable under some conditions on the parameters of the system determined by Routh-Hurwitz criterion. This paper also presents the adaptive modified function projective synchronization (AMFPS) between two identical Liu chaotic dynamical systems. Based on the Lyapunov stability theorem, adaptive control laws are designed to achieving the AMFPS. Finally, some numerical simulations are obtained to validate the proposed methods. 相似文献
Unsteady one-dimensional flows of two incompressible and immiscible generalized second grade fluids in a rectangular channel are studied. A constant pressure gradient acts in the flow direction, while the channel walls have oscillating translational motions in their planes. The generalization considered in this paper consists into a mathematical model based on constitutive equations of second grade fluid with Caputo time-fractional derivative in which the history of the shear stress influences the velocity gradient. The velocity and shear stress fields in the Laplace transform domain are obtained. Numerical solutions for the real velocity and shear stress have been found by employing the Stehfest numerical algorithm for the inverse Laplace transform. The influence of the fractional parameters on the velocity and shear stress has been studied by numerical simulations and graphical illustrations. It is found that the memory effects are significant only for small values of the time t. 相似文献
Twelve different samples of gel spheres were prepared from the biopolymers chitosan, alginate, and gelatin via polyion complex formation in aqueous solution with crosslinking by glutaraldehyde. Dropwise addition of a chitosan/gelatin solution into a solution containing alginate and glutaraldehyde gave the gel spheres. The effects of different ratios of glutaraldehyde (0.25%, 0.50%, 1.0%, and 2.0%), and gelatin (2.5%, 5.0%, and 10.0%) on the characteristics of the gel spheres were evaluated. An increase in the concentration of the glutaraldehyde led to forming true spheres in rigid form. By scanning electron microscopy (SEM), the gel spheres showed fibrous network propagation along the gel membrane surface. Fourier transform infrared (FT-IR) spectroscopy confirmed the crosslinking of the amino groups by the glutaraldehyde and the presence of crosslinking bonds between the amino groups of chitosan and the carboxyl groups in the alginate molecule. Swelling studies showed that increasing the degree of crosslinking increased the density of the polymer network, which led to a decrease in the degree of swelling. The characteristics of the gel spheres will be useful for immobilization and prolonged release of biologically active substances. 相似文献
The unsteady squeezing and extrusion of a viscous fluid between two parallel plates of constant temperature is examined. The dimensionless extrusion parameter,=U/V, is introduced to represent the effects of the extrusion on the squeezing velocities. The squeezing parameter=VH/, represents the effect of the inertial forces on heat and fluid flow characteristics. It is found that increasing the extrusion parameter will increase both the velocity and the heat transfer rates to the viscous fluid. Increasing the squeezing parameter had also decreased the fluid velocity and enhanced heat transfer rates. Increasing the viscous effects or the Eckert number E=U2/cp (TE – Ts) heated the fluid and consequently decreased the heat transfer rates. Different velocity profiles, temperature profiles, and Nusselt numbers against various dimensionless groups are drawn. 相似文献