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81.
An investor’s decisions affect the way taxes are paid in a general portfolio investment, modifying the net redemption value
and the yearly optimal portfolio distribution. We investigate the role of these decisions on multistage mean-variance portfolio
allocation model. A number of risky assets grouped in wrappers with special taxation rules is integrated in a multistage financial
portfolio optimization problem. The uncertainty on the returns of assets is specified as a scenario tree generated by simulation/clustering
based approach. We show the impact of decisions in the yearly reallocation of the investments for three typical cases with
an annual fixed withdrawal in a fixed horizon that utilizes completely the option of taper relief offered by banks in UK.
Our computational framework can be used as a tool for testing decisions in this context. 相似文献
82.
Nalan Gülpınar Dessislava Pachamanova Ethem Çanakoğlu 《European Journal of Operational Research》2013
This paper considers a stochastic facility location problem in which multiple capacitated facilities serve customers with a single product, and a stockout probabilistic requirement is stated as a chance constraint. Customer demand is assumed to be uncertain and to follow either a normal or an ambiguous distribution. We study robust approximations to the problem in order to incorporate information about the random demand distribution in the best possible, computationally tractable way. We also discuss how a decision maker’s risk preferences can be incorporated in the problem through robust optimization. Finally, we present numerical experiments that illustrate the performance of the different robust formulations. Robust optimization strategies for facility location appear to have better worst-case performance than nonrobust strategies. They also outperform nonrobust strategies in terms of realized average total cost when the actual demand distributions have higher expected values than the expected values used as input to the optimization models. 相似文献
83.
The extra chromosome 21 of Down syndrome (DS) or trisomy 21 patients contains an average of 40 extra copies of rRNA genes and the in vivo/in vitro regulation of the activity of these genes is not fully understood. The objective of this work was to compare the NORs expression pattern in interphase lymphocytes of DS patients with regular trisomy 21 and control individuals according to phytohemagglutinin (PHA) concentration (0.37, 0.75, 1.48 and 2.21 ml) per 100 ml of medium. Because the AgNOR staining is an indicator of the active rRNA genes, comparison of the image analysis values of the AgNOR area in 72 h cultivated lymphocytes for each concentration of PHA between DS patients (N=30) and controls (N=24) provided a plausible conclusion on the regulation of the extra rRNA genes in DS lymphocytes. The nucleolus organizer regions area/total nuclear area (NORa/TNa) was calculated using an in-house computer program. Fifty consecutive interphases per PHA concentration were analysed for each individual, for determination of the NORa/TNa. In contrast to healthy controls, NORa/TNa of lymphocytes from DS patient babies/children (0-8 years old) increased gradually in parallel with the PHA concentration in the culture medium: 10.44+/-1.72% for 0.37 ml of PHA, 11.74+/-1.93% for 0.75 ml of PHA, 13.25+/-2.03% for 1.48 ml of PHA and 13.43+/-2.08% for 2.21 ml of PHA per 100 ml of medium. Contrary to control cells (in which the NORa/TNa ratio according to PHA concentration in the culture medium remains constant), DS interphase lymphocytes in culture do not down-regulate their NOR expression. These results obtained from interphase NORs are consistent with the previous results obtained by evaluating the mean of AgNOR+ chromosome number in metaphase cells, also in relation to the mitogen concentration in the culture medium. 相似文献
84.
In this study, a mechanical system with linear deterioration and preventive maintenance is considered. The state of the system over time is represented by a semicontinuous stochastic process with dependent components. The system cycles through on and off periods during its lifetime. The state of the system deteriorates linearly as a function of the usage time during on periods. When the system is offline, preventive maintenance is conducted, which improves the system state by a random amount. The system's on and off times and random improvement amounts are assumed to have general distributions. For such a system, our objective is to determine the expected value and variance for the number of preventive maintenance activities needed during the system lifetime and to propose a novel replacement policy for the system based on delay‐time modeling. Finally, the effectiveness of the obtained asymptotic results and the proposed replacement policy are tested through simulation. 相似文献
85.
Burcu Somtürk Ramazan Kalın Nalan Özdemir 《Applied biochemistry and biotechnology》2014,173(7):1815-1828
Peroxidase was purified in a single step using 4-amino benzohydrazide affinity chromatography from red cabbage (Brassica oleracea var. capitata f. rubra), and some important biochemical characteristics of the purified enzyme were determined. The enzyme, with a specific activity of 3,550 EU/mg protein, was purified 120.6-fold with a yield of 2.9 % from the synthesized affinity matrix. The molecular weight of the enzyme was found to be 69.3 kDa by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The enzyme exhibited maximum activity at pH 7.0 and 30 °C. For guaiacol substrate, the K m and V max values were found as 0.048 mM and 1.46 EU/mL/min, respectively. Additionally, the IC50 and K i values for 4-amino benzohydrazide were calculated to be 1.047 and 0.702?±?0.05 mM, respectively, and 4-amino benzohydrazide showed noncompetitive inhibition. 相似文献
86.
Extra chromosome 21 of Down syndrome (DS) or trisomy 21 patients contains an average of 40 extra copies of rRNA genes and the in vivo regulation of these genes is not known. The objective of this work is to compare the NORs expression in interphase nuclei in non-stimulated lymphocytes of DS patients and healthy controls. Because the AgNOR staining is the indicator of the active rRNA genes, comparison of the image analysis values of AgNORs area between DS's and healthy controls' interphase lymphocytes is considered to be sufficient to evaluate the level of rDNA activities in the two groups. The Nucleolus Organizer Regions area/Total Nuclear area (NORa/TNa) was calculated using a computer program designed by us. 100 consecutive NORa/TNa per individual were evaluated. We report that 24 DS children's peripheral lymphocytes show significantly higher NORa/TNa mean value (6.32 +/- 1.77%) than that of the 20 healthy controls' cells (5.31 +/- 1.34%) (2-tailed Mann-Whitney U test, z = 19.4, P = 0.000). The same is true for the nucleolus (AgNOR spot) number per nucleus. The mean value of nucleoli number per nucleus in DS lymphocytes was significantly higher than that of the controls: z = 14.6, P = 0.000. In conclusion, extra rRNA genes on the chromosome 21 are not down-regulated in DS patients' lymphocytes. Rather, extra NORs expressions in 'in vivo' condition contribute to the increase of AgNORs area and AgNOR spots number per nucleus. This is the first work on the comparison of NORs activities in resting (non-stimulated) interphase lymphocytes between DS and healthy controls. 相似文献
87.
Veronica Marin Elisabeth Holder Martijn M. Wienk Emine Tekin Dmitry Kozodaev Ulrich S. Schubert 《Macromolecular rapid communications》2005,26(4):319-324
Summary: We illustrate the ink‐jet printing of a thin‐film library of donor/acceptor systems useful in bulk heterojunction solar cells and their characterization utilizing a UV‐vis/fluorescence plate reader and an optical profilometer. In addition, the morphology of the films has been examined by atomic force microscopy (AFM). The ink‐jet processing technology allows printing of arrays of different donor/acceptor compositions on one substrate as well as the subsequent fast optical screening of the electron transfer processes. The investigated films consist of blends of a poly(methyl methacrylate) polypyridyl ruthenium(II ) copolymer (RuPMMA) as electron donor material (p‐type) and C60 fullerene (PC60BM) as well as heptyl viologen (C7‐V) derivatives as electron acceptor materials (n‐type).
88.
Ahmet Kilic Tuğba Ersayan Balci Nevin Arslan Murat Aydemir Feyyaz Durap Veysi Okumuş Recep Tekin 《应用有机金属化学》2020,34(10):e5835
Two cis-1,2-diol-type chiral ligands (T 1 and T 2 ) and their tri-coordinated chiral dioxaborinane (T (1–2) B (1–2) ) and four-coordinated chiral dioxaborinane adducts with 4-tert-butyl pyridine sustained by N → B dative bonds (T (1–2) B (1–2) -N) were synthesized and characterized by various spectroscopic techniques such as NMR (1H, 13C, and 11B), FT-IR and UV–Vis spectroscopy, LC–MS/MS, and elemental analysis. It was suggested that both ferrocene and trifluoromethyl groups played key roles in the catalytic and biological studies because they could tune the solubility of the chiral dioxaborinane complexes and adjust the strength of intermolecular interactions. To assess the biological activities of newly synthesized chiral dioxaborinane compounds, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, reducing power, antibacterial, DNA binding, and DNA cleavage activities were tested. Then, all chiral dioxaborinane complexes were investigated as catalysts for the asymmetric transfer hydrogenation of various ketones under suitable conditions. The results indicated that the chiral dioxaborinane catalysts performed well with high yields. 相似文献
89.
This study focused on the preparation and characterization of water-in-oil-in-water (W1/O/W2)-type double emulsions designed by food-grade emulsifiers and stabilizers. The primary objective of this study was to compare different emulsion formulations in terms of droplet size, rheology, and stability and to reduce the amount of polyglycerol poliricinoleate (PGPR). To achieve these goals, PGPR and a PGPR–lecithin blend were utilized in the formation of the primary phase (W1/O), while varying concentrations of guar gum (GG) and gum tragacanth (GT) incorporated in the secondary water phase (W2). Shear thinning behavior was observed for all emulsion formulations. Sauter mean diameters of the emulsions prepared with PGPR as a hydrophobic emulsifier ranged between 30?µm and 75?µm, while those prepared with the PGPR–lecithin blend varied between 25?µm and 85?µm based on the first day’s measurements. In emulsions with the PGPR–lecithin blend, the smallest droplet size was obtained when the GG–GT blend was incorporated in the external aqueous phase. Moreover, GG–GT blends had high consistency coefficients and high apparent viscosity values. It was also observed that PGPR–lecithin containing emulsions were more stable. 相似文献
90.
The synthesis, characterisation and biological activity of water‐soluble Ag(I)‐NHC complexes, general formula Na[(NHC)AgCl] where NHC is a sulfonated and sterically hindered N‐heterocyclic carbene, is reported. The Ag‐NHC complexes (2a–e) were synthesised by reacting the corresponding sulfonated NHC ligands with Ag2O in the presence of NaCl or NaBr in methanol/water (1:1) solution. Synthesised silver (I)‐N‐heterocyclic carbene complexes have been characterised by NMR, micro‐analysis and HRMS spectroscopic methods. The IC50 values of these complexes were determined by a proliferation BrdU enzyme‐linked immunosorbent assay (ELISA) against HeLa (human cervix carcinoma), HT29 (human adenocarcinoma) and L929 (mouse fibroblast) cell lines. These complexes have been highlighted as promising and original platforms for building new types of metalodrug. All new water‐soluble Ag(I) complexes demonstrated remarkable cytotoxic activity against HeLa, HT29 and L929 cell lines. 相似文献