Signature splitting in two quasiparticle rotational bands of <Superscript>180,182</Superscript>Ta

The signature splittings in K^π = 1 ⁺: 7 /2[404] _π?9 /2[624] _ν, K^π = 0^?: 9 /2[514] _π?9 /2[624] _ν bands of ¹⁸⁰Ta and K^π = 0^?: 7 /2[404] _π?7 /2[503] _ν, K^π = 1^?: 5 /2[402] _π?3 /2[512] _ν, K^π = 1⁺: 7 /2[404] _π?9 /2[624] _ν bands of ¹⁸²Ta are analysed within the framework of two-quasiparticle rotor model. The phase as well as magnitude of the experimentally observed signature splitting in K^π = 1⁺ band of ¹⁸⁰Ta, which could not be explained in earlier calculations, is successfully reproduced. The conflict regarding placement of a 12 ⁺ level in K^π = 1 ⁺: 7 /2 ⁺[404] _π?9 /2 ⁺[624] _ν ground-state rotational band of ¹⁸⁰Ta is resolved and tentative nature of K^π = 0^?: 7 /2[404] _π?7 /2[503] _ν, K^π = 1⁺: 7 /2[404] _π?9 /2[624] _ν bands observed in ¹⁸²Ta is confirmed. As a future prediction for experimentalists, these two-quasiparticle structures observed in ¹⁸⁰Ta and ¹⁸²Ta are extended to higher spins.     

Scattering chamber facility for double-differential cross-section measurement with 14 MeV DT neutron generator at IPR

Measurement of double-differential cross-sections of 14 MeV neutron-induced charged-particle productions is very important for estimating the nuclear heating and radiation damage of a fusion reactor. Only a few experimental data are available even though the nuclear reaction cross-section data of structural materials are important in fusion nuclear technology. In this context, general purpose scattering chamber facility has been developed for accelerator-based 14 MeV DT neutron generator to measure double-differential nuclear reaction cross-section at Fusion Neutronics Laboratory, IPR. It has been designed for experiments using silicon surface barrier detectors for the online detection of charged particles. It offers flexibility in the arrangement of silicon surface barrier detectors.     

Axioms of spheres in lightlike geometry of submanifolds

We prove that if an indefinite Kaehler manifold \(\bar {M}\) with lightlike submanifolds satisfies the axioms of holomorphic 2r-spheres, axioms of holomorphic 2r-planes, axioms of transversal r-spheres and axioms of transversal r-planes, then it is an indefinite complex space form.     

Nonplanar ion-acoustic shocks in electron–positron–ion plasmas: Effect of superthermal electrons

Ion-acoustic shock waves (IASWs) in a homogeneous unmagnetized plasma, comprising superthermal electrons, positrons, and singly charged adiabatically hot positive ions are investigated via two-dimensional nonplanar Kadomstev–Petviashvili–Burgers (KPB) equation. It is found that the profiles of the nonlinear shock structures depend on the superthermality of electrons. The influence of other plasma parameters such as, ion kinematic viscosity and ion temperature, is discussed in the presence of superthermal electrons in nonplanar geometry. It is also seen that the IASWs propagating in cylindrical/spherical geometry with transverse perturbation will be deformed as time goes on.     

Effect of nonthermal distributed electrons and temperature on phase shifts during the collision of inward and outward ion-acoustic solitary waves in nonplanar geometry

Interaction of nonplanar ion-acoustic solitary waves is an important source of information for studying the nature and characteristics of ion-acoustic solitary waves (IASWs). The head-on collision between two cylindrical/spherical IASWs in un-magnetized plasmas comprising of nonthermal distributed electrons and warm ions is investigated using the extended version of Poincaré–Lighthill–Kuo (PLK) perturbation method. How the interactions are taking place in cylindrical and spherical geometries are shown numerically. Analytical phase shifts are derived for nonplanar geometry. The effects of the ion to electron temperature parameter and the nonthermal electrons parameter on the phase shift are studied. It is shown that the properties of the interaction of IASWs in different geometries are very different.     

Anisotropic cosmological models in f (R, T) theory of gravitation

A class of non-singular bouncing cosmological models of a general class of Bianchi models filled with perfect fluid in the framework of f(R,T) gravity is presented. The model initially accelerates for a certain period of time and decelerates thereafter. The physical behaviour of the model is also studied.     

Integrated 3D-QSAR,molecular docking,and molecular dynamics simulation studies on 1,2,3-triazole based derivatives for designing new acetylcholinesterase inhibitors

Alzheimer’s disease (AD) is a multifactorial and polygenic disease. It is the most prevalent reason for dementia in the aging population. A dataset of twenty-six 1,2,3-triazole-based derivatives previously synthetized and evaluated for acetylcholinesterase inhibitory activity were subjected to the three-dimensional quantitative structure-activity relationship (3D-QSAR) study. Good predictability was achieved for comparative molecular field analysis (CoMFA) (Q² = 0.604, R² = 0.863, r_ext² = 0.701) and comparative molecular similarity indices analysis (CoMSIA) (Q² = 0.606, R² = 0.854, r_ext² = 0.647). The molecular features characteristics provided by the 3D-QSAR contour plots were quite useful for designing and improving the activity of acetylcholinesterase of this class. Based on these findings, a new series of 1,2,3-triazole based derivatives were designed, among which compound A1 with the highest predictive activity was subjected to detailed molecular docking and compared to the most active compound. The selected compounds were further subjected to 20 ns molecular dynamics (MD) simulations to study the comparative conformation dynamics of the protein after ligand binding, revealing promising results for the designed molecule. Therefore, this study could provide worthy guidance for further experimental analysis of highly effective acetylcholinesterase inhibitors.     

Exact solutions of some physical models using the (<Emphasis Type="Italic">G</Emphasis>′/<Emphasis Type="Italic">G</Emphasis>)-expansion method

The (G′/G)-expansion method and its simplified version are used to obtain generalized travelling wave solutions of five nonlinear evolution equations (NLEEs) of physical importance, viz. the (2+1)-dimensional Maccari system, the Pochhammer–Chree equation, the Newell–Whitehead equation, the Fitzhugh–Nagumo equation and the Burger–Fisher equation. A variety of special solutions like periodic, kink–antikink solitons, bell-type solitons etc. can easily be derived from the general results. Three-dimensional profile plots of some of the solutions are also drawn.     

以液体核磁共振波谱分析与帕金森氏病相关的I93M 突变对人类泛素碳端水解酶结构的影响

人类泛素碳端水解酶（UCH-L1）是涉及帕金森氏病并且在神经元高度表达的蛋白．UCH-L1 的家族性突变与转译后修饰会引起聚集倾向增加与去泛素活性损失,这二者都可能成为致病因素．作者所在实验室之前的研究指出与帕金森氏病相关的突变I93M 显著降低UCH-L1 的折叠稳定性并且加速其构型展开动力学．该研究使用液体核磁共振分析方法,包括侧链甲基化学位移,松弛骨干动力学和残余偶极耦合,以进一步阐明I93M 突变如何影响UCH-L1 的结构和动态．结果显示I93M 显著影响突变位点周围的疏水核心侧链构型．然而,这样的结构扰动并不会影响在纳秒时间尺度的快速骨干动力学．透过残余偶极耦合分析显示UCH-L1 在水溶液中的结构与之前报道的晶体结构有相当显著的偏离,另外I93M 突变也导致超出突变位点的远距离结构扰动．这一系列水溶液结构的分析结果可补充之前已知的晶体学数据,并对UCH-L1 在帕金森氏病相关的基因突变影响并提供详细的见解．     

Optimal treatment of stratified Carreau and Casson nanofluids flows in Darcy-Forchheimer porous space over porous matrix

A comparative three-dimensional (3D) analysis for Casson-nanofluid and Carreau-nanofluid flows due to a flat body in a magnetohydrodynamic (MHD) stratified environment is presented. Flow is estimated to be suspended in a Darcy-Forchheimer medium. Soret and Dufour responses are also accommodated in the flow field. A moving (rotating) coordinate system is exercised to examine the bidirectionally stretched flow fields (flow, heat transfer, and mass transfer). Nanofluid is compounded by taking ethylene glycol/sodium alginate as base fluid and ferric-oxide (Fe₃O₄) as nanoparticles. Governing equations are handled by the application of optimal homotopy asymptotic method (OHAM), where convergence parameters are optimized through the classical least square procedure. The novel mechanism (hidden physics) due to appearing parameters is explored with the assistance of tabular and graphical expositions. Outcomes reveal the double behavior state for temperature field with thermal stratification/Dufour number, and for concentration field with Soret number due to the presence of turning points.