Mg和Ni共掺杂的ZnO稀释磁性半导体在磁性和光催化的应用

随着引入磁性元素,氧化锌最近被广泛用作磁性半导体. 本文报告了Mg和Ni共掺杂的ZnO的纯相合成,并研究其结构、光学、磁性和光催化特性. X射线衍射分析显示其六方纤锌矿型结构具有P63mc构型且不含任何杂质. 紫外可见分光光度法表明,随着ZnO中掺杂的Mg和Ni含量增加,带隙发生变化. 磁性测量实验显示Ni和Mg共掺杂的ZnO磁性加强,带隙的稳定进一步证实其结构的稳定性,实现了其在现代自旋电子设备的磁调谐性能. 对甲基绿的光催化降解实验结果表明,Mg和Ni共掺杂ZnO的活性增强.     

New Biologically Hybrid Pharmacophore Thiazolidinone-Based Indole Derivatives: Synthesis,In Vitro Alpha-Amylase and Alpha-Glucosidase along with Molecular Docking Investigations

Amylase and glucosidase enzymes are the primary harmful source in the development of the chronic condition known as diabetes mellitus. The main function of these enzymes is to break the macromolecules into simple sugar units which are directly involved in the solubility of blood, hence increasing blood glucose levels. To overcome this effect, there is a need for a potent and effective inhibitor that inhibits the conversion of macromolecules of sugar into its smaller units. In this regard, we synthesized thiazolidinone-based indole derivatives (1–20). The synthesized derivatives were evaluated for α-amylase and α-glucosidase inhibitory activity. Different substituted derivatives were found with moderate to good potentials having IC₅₀ values ranging, for α-amylase, from 1.50 ± 0.05 to 29.60 ± 0.40 μM and, for α-glucosidase, from IC₅₀ = 2.40 ± 0.10 to 31.50 ± 0.50 μM. Among the varied substituted compounds, the most active analogs four (1.80 ± 0.70 and 2.70 ± 0.70), five (1.50 ± 0.05 and 2.40 ± 0.10, respectively) of the series showed few folds better inhibitory activity than standard drug acarbose (IC₅₀ = 10.20 ± 0.10 and 11.70 ± 0.10 μM, respectively). Moreover, structure–activity relationship (SAR) was established and binding interactions were analyzed for ligands and proteins (α-amylase and α-glucosidase) through a molecular docking study.     

Synthesis,In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase

The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (1–16) in which a number of reaction steps were involved. To examine their biological activity in the presence of the reference drug Donepezil (0.21 ± 0.12 and 0.30 ± 0.32 M, respectively), the inhibitory potentials of AChE and BuChE were determined for these compounds. Different substituted derivatives showing a varied range of inhibitory profiles, when compared to the reference drug, analogue 8 was shown to have potent activity, with IC50 values for AchE 0.15 ± 0.050 M and BuChE 0.20 ± 0.10, respectively, while other substituted compounds displayed good to moderate potentials. Varied spectroscopic techniques including ¹H, ¹³CNMR and HREI-MS were used to identify the basic skeleton of these compounds. Furthermore, all analogues have a known structure–activity relationship (SAR), and molecular docking investigations have verified the binding interactions of molecule to the active site of enzymes.     

Cation Incorporation and Synergistic Effects on the Characteristics of Sulfur-Doped Manganese Ferrites S@Mn(Fe2O4) Nanoparticles for Boosted Sunlight-Driven Photocatalysis

In the present work, sulfur-doped manganese ferrites S@Mn(Fe₂O₄) nanoparticles were prepared by using the sol-gel and citrate method. The concentration of sulfur varied from 1 to 7% by adding Na₂S. The samples were characterized by performing Fourier Transformed Infrared Spectroscopy (FTIR), Energy Dispersive X-ray (EDX), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and Ultraviolet–Visible spectroscopy (UV–Visible). The synthesized sulfur-doped manganese ferrites were applied to evaluate the photocatalytic degradation of the dyes. Further, the degradation studies revealed that the nanoparticles successfully degraded the methylene blue dye by adding a 0.006 g dose under the sunlight. The sulfur-doped manganese ferrite nanoparticles containing 3% sulfur completely degraded the dye in 2 h and 15 min in aqueous medium. Thus, the ferrite nanoparticles were found to be promising photocatalyst materials and could be employed for the degradation of other dyes in the future.     

Simultaneous Quantification of Opioids in Blood and Urine by Gas Chromatography-Mass Spectrometer with Modified Dispersive Solid-Phase Extraction Technique

Common methodologies such as liquid-liquid extraction and solid-phase extraction are applied for the extraction of opioids from biological specimens i.e., blood and urine. Techniques including LC-MS/LC-MSMS, GC-MS, etc. are used for qualitative or quantitative determination of opioids. The goal of the present work is to design a green, economic, rugged, and simple extraction technique for famous opioids in human blood and urine and their simultaneous quantification by GC-MS equipped with an inert plus electron impact (EI) ionization source at SIM mode to produce reproducible and efficient results. Morphine, codeine, 6-acetylmorphine, nalbuphine, tramadol and dextromethorphan were selected as target opioids. Anhydrous Epsom salt was applied for dSPE of opioids from blood and urine into acetonitrile extraction solvent with the addition of sodium phosphate buffer (pH 6) and n-hexane was added to remove non-polar interfering species from samples. BSTFA was used as a derivatizing agent for GC-MS. Following method validation, the LOD/LLOQ and ULOQ were determined for morphine, codeine, nal-buphine, tramadol, and dextromethorphan at 10 ng/mL and 1500 ng/mL, respectively, while the LOD/LLOQ and ULOQ were determined for 6-acetylmorphine at 5 ng/mL and 150 ng/mL, respectively. This method was applied to real blood and urine samples of opioid abusers and the results were found to be reproducible with true quantification.     

Improvement in Optoelectronic Properties of Bismuth Sulphide Thin Films by Chromium Incorporation at the Orthorhombic Crystal Lattice for Photovoltaic Applications

By using the chemical bath deposition approach, binary bismuth sulphides (Bi₂S₃) and chromium-doped ternary bismuth sulphides (Bi_2−xCr_xS₃) thin films were effectively produced, and their potential for photovoltaic applications was examined. Structural elucidation revealed that Bi₂S₃ deposited by this simple and cost-effective method retained its orthorhombic crystal lattice by doping up to 3 at.%. The morphological analysis confirmed the crack-free deposition, hence making them suitable for solar cell applications. Optical analysis showed that deposited thin films have a bandgap in the range of 1.30 to 1.17 eV, values of refractive index (n) from 2.9 to 1.3, and an extinction coefficient (k) from 1.03 to 0.3. From the Hall measurements, it followed that the dominant carriers in all doped and undoped samples are electrons, and the carrier density in doped samples is almost two orders of magnitude larger than in Bi₂S₃. Hence, this suggests that doping is an effective tool to improve the optoelectronic behavior of Bi₂S₃ thin films by engineering the compositional, structural, and morphological properties.     

Integration of Mn-ZnFe2O4 with S-g-C3N4 for Boosting Spatial Charge Generation and Separation as an Efficient Photocatalyst

The disposal of dyes and organic matter into water bodies has become a significant source of pollution, posing health risks to humans worldwide. With rising water demands and dwindling supplies, these harmful compounds must be isolated from wastewater and kept out of the aquatic environment. In the research presented here, hydrothermal synthesis of manganese-doped zinc ferrites’ (Mn-ZnFe₂O₄) nanoparticles (NPs) and their nanocomposites (NCs) with sulfur-doped graphitic carbon nitride (Mn-ZnFe₂O₄/S-g-C₃N₄) are described. The samples’ morphological, structural, and bonding features were investigated using SEM, XRD, and FTIR techniques. A two-phase photocatalytic degradation study of (0.5, 1, 3, 5, 7, 9, and 11 wt.%) Mn-doped ZnFe₂O₄ NPs and Mn-ZnFe₂O₄/(10, 30, 50, 60, and 70 wt.%) S-g-C₃N₄ NCs against MB was carried out to find the photocatalyst with maximum efficiency. The 9% Mn-ZnFe₂O₄ NPs and Mn-ZnFe₂O₄/50% S-g-C₃N₄ NCs exhibited the best photocatalyst efficiency in phase one and phased two, respectively. The enhanced photocatalytic activity of the Mn-ZnFe₂O₄/50% S-g-C₃N₄ NCs could be attributed to synergistic interactions at the Mn-ZnFe₂O₄/50% S-g-C₃N₄ NCs interface that resulted in a more effective transfer and separation of photo-induced charges. Therefore, it is efficient, affordable, and ecologically secure to modify ZnFe₂O₄ by doping with Mn and homogenizing with S-g-C₃N₄. As a result, our current research suggests that the synthetic ternary hybrid Mn-ZnFe₂O₄/50% S-g-C₃N₄ NCs may be an effective photocatalytic system for degrading organic pollutants from wastewater.     

不同结构SAPO-34催化剂上1-己烯催化裂解制丙烯

制备了100%SAPO-34,30%SAPO-34和介孔-SAPO-34三种不同类型的SAPO-34分子筛催化剂,并采用氮吸附、扫描电镜、X射线衍射和红外光谱等方法对催化剂进行了表征.三种催化剂的微孔结构、比表面积和总酸最近似,但具有不同的催化剂组成和次级结构.以1-己烯裂解为模型反应考察了三种催化剂的催化活性.对于30%SAPO-34催化剂,由于添加了粘结剂.其外表面酸性和扩散性能下降,导致催化活性降低:100%SAPO-34催化剂则具有较好的催化性能:介孔 SAPO-34催化剂次级结构的存在使其失活较慢,从而提高了原料的转化率.详细讨论了1-己烯催化裂解制丙烯的活性和选择性曲线,以进一步说明催化剂组成和结构的影响.     

Thermodynamic and Spectroscopic Studies of Pentoxifylline in Aqueous Glucose/Lactose Solutions

Journal of Solution Chemistry - The density, speed of sound and viscosity data of drug pentoxifylline in aqueous solutions of glucose (monosaccharide) and lactose (disaccharide) were determined....