全文获取类型
收费全文 | 129篇 |
免费 | 1篇 |
专业分类
化学 | 92篇 |
晶体学 | 1篇 |
数学 | 2篇 |
物理学 | 35篇 |
出版年
2022年 | 1篇 |
2021年 | 3篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 7篇 |
2014年 | 3篇 |
2013年 | 5篇 |
2012年 | 7篇 |
2011年 | 12篇 |
2010年 | 1篇 |
2009年 | 3篇 |
2008年 | 8篇 |
2007年 | 7篇 |
2005年 | 4篇 |
2004年 | 6篇 |
2003年 | 6篇 |
2002年 | 2篇 |
2001年 | 3篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1997年 | 1篇 |
1996年 | 5篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 1篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有130条查询结果,搜索用时 15 毫秒
31.
The objective of this study was to investigate the effect of the crystallization behavior of Macrogol 6000 (polyethylene glycol 6000; PEG 6000), used as a binder, during the solidification process on the properties of mononucleic granules prepared by the fluidized hot-melt granulation (FHMG) technique. Crystallization of PEG 6000 from molten liquid was investigated using differential scanning calorimetry (DSC) and hot stage microscopy. The results obtained from the measurement of isothermal crystallization demonstrated that crystallization of PEG 6000 was either slow or rapid. Analysis based on solid-state decomposition showed that slow crystallization was due to the two-dimensional growth of nuclei mechanism, while rapid crystallization was due to the three-dimensional growth of nuclei mechanism. Observation of the crystallization of PEG 6000 by hot stage microscopy supported the existence of two different crystallization mechanisms. Granules containing PEG 6000 that underwent rapid crystallization during FHMG showed a significantly higher fraction powder under 150 microm in diameter. This was caused by the loss of powder particles from the surface of mononucleic granules during the solidification process, because many cracks were observed after crystallization of PEG 6000 with a short isothermal crystallization time (ICT) due to the reduced of sticking of particles. The results of this study suggested that the crystallization behavior of the binder during the solidification process of FHMG can influence the properties of the resultant granules, such as particle size distribution, content uniformity or taste masking. It was also indicated that measuring the ICT using DSC was a useful method to classify PEG 6000. 相似文献
32.
Roongsawang N Hase Ki Haruki M Imanaka T Morikawa M Kanaya S 《Chemistry & biology》2003,10(9):869-880
Arthrofactin is a potent cyclic lipopeptide-type biosurfactant produced by Pseudomonas sp. MIS38. In this work, an arthrofactin synthetase gene cluster (arf) spanning 38.7 kb was cloned and characterized. Three genes termed arfA, arfB, and arfC encode ArfA, ArfB, and ArfC, containing two, four, and five functional modules, respectively. Each module bears condensation, adenylation, and thiolation domains, like other nonribosomal peptide synthetases. However, unlike most of them, none of the 11 modules possess the epimerization domain responsible for the conversion of amino acid residues from L to D form. Possible L- and D-Leu adenylation domains specifically recognized only L-Leu. Moreover, two thioesterase domains are tandemly located at the C-terminal end of ArfC. These results suggest that ArfA, ArfB, and ArfC assemble to form a unique structure. Gene disruption of arfB impaired arthrofactin production, reduced swarming activity, and enhanced biofilm formation. 相似文献
33.
Vanadium oxyacetylacetonate [VO(acac)(2)] works as a catalyst for the direct synthesis of 3-sulfanylindoles from indoles and thiols under an atmospheric pressure of molecular oxygen as a reoxidant. For example, the reaction of 2-phenylindole with benzenethiol in the presence of a catalytic amount of VO(acac)(2), potassium iodide, and 2,6-di-tert-butyl-p-cresol in chlorobenzene under molecular oxygen proceeds to afford 2-phenyl-3-(phenylsulfanyl)indole in 86% yield. This catalytic system can also be applied to 2-naphthols instead of indoles to give the corresponding 1-sulfanyl-2-naphthols in up to 57% yield. 相似文献
34.
Hisayuki Horai Masanori Arita Shigehiko Kanaya Yoshito Nihei Tasuku Ikeda Kazuhiro Suwa Yuya Ojima Kenichi Tanaka Satoshi Tanaka Ken Aoshima Yoshiya Oda Yuji Kakazu Miyako Kusano Takayuki Tohge Fumio Matsuda Yuji Sawada Masami Yokota Hirai Hiroki Nakanishi Kazutaka Ikeda Naoshige Akimoto Takashi Maoka Hiroki Takahashi Takeshi Ara Nozomu Sakurai Hideyuki Suzuki Daisuke Shibata Steffen Neumann Takashi Iida Ken Tanaka Kimito Funatsu Fumito Matsuura Tomoyoshi Soga Ryo Taguchi Kazuki Saito Takaaki Nishioka 《Journal of mass spectrometry : JMS》2010,45(7):703-714
MassBank is the first public repository of mass spectra of small chemical compounds for life sciences (<3000 Da). The database contains 605 electron‐ionization mass spectrometry(EI‐MS), 137 fast atom bombardment MS and 9276 electrospray ionization (ESI)‐MSn data of 2337 authentic compounds of metabolites, 11 545 EI‐MS and 834 other‐MS data of 10 286 volatile natural and synthetic compounds, and 3045 ESI‐MS2 data of 679 synthetic drugs contributed by 16 research groups (January 2010). ESI‐MS2 data were analyzed under nonstandardized, independent experimental conditions. MassBank is a distributed database. Each research group provides data from its own MassBank data servers distributed on the Internet. MassBank users can access either all of the MassBank data or a subset of the data by specifying one or more experimental conditions. In a spectral search to retrieve mass spectra similar to a query mass spectrum, the similarity score is calculated by a weighted cosine correlation in which weighting exponents on peak intensity and the mass‐to‐charge ratio are optimized to the ESI‐MS2 data. MassBank also provides a merged spectrum for each compound prepared by merging the analyzed ESI‐MS2 data on an identical compound under different collision‐induced dissociation conditions. Data merging has significantly improved the precision of the identification of a chemical compound by 21–23% at a similarity score of 0.6. Thus, MassBank is useful for the identification of chemical compounds and the publication of experimental data. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
35.
Yasuhiro Isogai Anna Ishii Manabu Ishida Masahiro Mukai Motonori Ota Ken Nishikawa Tetsutaro Iizuka 《Journal of Chemical Sciences》2000,112(3):215-221
De novo design of artificial proteins is an essential approach to elucidate the principles of protein architecture and to understand
specific functions of natural proteins and also to yield novel molecules for medical and industrial aims. We have designed
artificial sequences of 153 amino acids to fit the main-chain framework of the sperm whale myoglobin structure based on the
knowledge-based energy functions to evaluate the compatibility between protein tertiary structures and amino acid sequences.
The synthesized artificial globins bind a single heme per protein molecule as designed, which show well-defined electrochemical
and spectroscopic features characteristic of proteins with a low-spin heme. Redox and ligand binding reactions of the artificial
heme proteins were investigated and these heme-related functions were found to vary with their structural uniqueness. Relationships
between the structural and functional properties are discussed. 相似文献
36.
37.
Masahiro Suzuki Motonori Sano Mutsumi Kimura Kenji Hanabusa Hirofusa Shirai 《Journal of polymer science. Part A, Polymer chemistry》1999,37(23):4360-4367
A series of ruthenium(II) complex-containing partially quaternized poly(1-vinylimidazole)s with various alkyl side chains such as hexyl (C6RuQPIm), dodecyl (C12RuQPIm), and hexadecyl (C16RuQPIm) were synthesized. The effects of L -tyrosine esters with hexyl (C6Tyr), octyl (C8Tyr), and dodecyl (C12Tyr) on the quenching with methylviologen and photosensitized charge separation reactions were investigated using these metallopolymers as polymer photosensitizers. The quenching reaction took place through both a dynamic quenching process and a static quenching one mediated by the L -tyrosine esters. The kinetic parameters for these processes were obtained from a computed curve fitting using a Stern–Volmer equation derived from a combination of dynamic quenching and static quenching. The parameters had a significant dependence on the lengths of the alkyl groups in the L -tyrosine esters and the alkyl side chains on these metallopolymers. During photosensitized charge separation, the reaction proceeded through these quenching processes, referred to as direct and mediated processes. The initial rates of methylviologen radical formation also depended on these lengths; they increased when the lengths of the alkyl side chain on these metallopolymers and alkyl groups in the L -tyrosine esters were long. Such a dependence was caused by a change in the balance of some effects such as the electrostatic and steric effects. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 4360–4367, 1999 相似文献
38.
Aoki S Fukugita M Hashimoto S Ishikawa KI Ishizuka N Iwasaki Y Kanaya K Kaneko T Kuramashi Y Okawa M Onogi T Tsutsui N Ukawa A Yamada N Yoshié T;JLQCD Collaboration 《Physical review letters》2003,91(21):212001
We present an unquenched lattice calculation for the B(0)-B(0) transition amplitude. The calculation, carried out at an inverse lattice spacing 1/a=2.22(4) GeV, incorporates two flavors of dynamical quarks described by the O(a)-improved Wilson fermion action and heavy quarks described by nonrelativistic QCD. Particular attention is paid to the uncertainty that arises from the chiral extrapolation, especially the effect of pion loops, for light quarks, which we find could be sizable for the leptonic decay constant, whereas it is small for the B parameters. We obtain f(B(d))=191(10)(+12-22) MeV, f(B(s))/f(B(d))=1.13(3)(+13-2), B(B(d))(m(b))=0.836(27)(+56-62), B(B(s))/B(B(d))=1.017(16)(+56-17), and xi=1.14(3)(+13-2), where the first error is statistical, and the second is systematic, including uncertainties due to chiral extrapolation, finite lattice spacing, heavy quark expansion, and perturbative operator matching. 相似文献
39.
40.
W. Bock H. G. Evertz K. Jansen J. Jersák K. Kanaya H. A. Kastrup D. P. Landau T. Neuhaus J. L. Xu 《Zeitschrift fur Physik C Particles and Fields》1990,45(4):597-605
Using theSU (2) Higgs system with dynamical scalar matter fields as a model for analyzing screening properties of the confining potential in gauge theories, we examine the Wilson loopW (T, R) and the gauge invariant 2-point functionG(T, R) by Monte Carlo simulations on a 164 lattice. For small values of the hopping parameterk these quantities show non-asymptotic area law behavior which changes to asymptotic perimeter law behavior ask increases. Close to the Higgs phase transition we find an indication that both these asymptotic and nonasymptotic terms are present simultaneously within the lattice at different distancesR andT and that the breaking of the confining flux tube by matter pair production occurs within the lattice. Introducing an appropriate ansatz forW(T, R) andG(T, R), respectively, we determine in this complex situation the string tension, the screening energy of the external sources, and the order parameter introduced by Fredenhagen and Marcu. 相似文献