全文获取类型
收费全文 | 158篇 |
免费 | 4篇 |
专业分类
化学 | 110篇 |
晶体学 | 1篇 |
数学 | 11篇 |
物理学 | 40篇 |
出版年
2022年 | 1篇 |
2021年 | 2篇 |
2019年 | 2篇 |
2016年 | 2篇 |
2014年 | 4篇 |
2013年 | 8篇 |
2012年 | 9篇 |
2011年 | 7篇 |
2010年 | 3篇 |
2009年 | 7篇 |
2008年 | 8篇 |
2007年 | 5篇 |
2006年 | 3篇 |
2005年 | 12篇 |
2004年 | 9篇 |
2003年 | 2篇 |
2002年 | 4篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1998年 | 1篇 |
1996年 | 4篇 |
1995年 | 17篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1987年 | 1篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1982年 | 2篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1970年 | 3篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1966年 | 5篇 |
1965年 | 2篇 |
1964年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有162条查询结果,搜索用时 15 毫秒
131.
Xue-Ni Hou Dr. Naotaka Sekiyama Yasuko Ohtani Dr. Feng Yang Dr. Yohei Miyanoiri Dr. Ken-ichi Akagi Prof. Dr. Xun-Cheng Su Prof. Dr. Hidehito Tochio 《Chemphyschem》2021,22(14):1505-1517
Linear polyubiquitin chains regulate diverse signaling proteins, in which the chains adopt various conformations to recognize different target proteins. Thus, the structural plasticity of the chains plays an important role in controlling the binding events. Herein, paramagnetic NMR spectroscopy is employed to explore the conformational space sampled by linear diubiquitin, a minimal unit of linear polyubiquitin, in its free state. Rigorous analysis of the data suggests that, regarding the relative positions of the ubiquitin units, particular regions of conformational space are preferentially sampled by the molecule. By combining these results with further data collected for charge-reversal derivatives of linear diubiquitin, structural insights into the factors underlying the binding events of linear diubiquitin are obtained. 相似文献
132.
Goro Akagi Kazumasa Suzuki 《Calculus of Variations and Partial Differential Equations》2008,31(4):457-471
The existence, uniqueness and regularity of viscosity solutions to the Cauchy–Dirichlet problem are proved for a degenerate
nonlinear parabolic equation of the form , where denotes the so-called infinity-Laplacian given by . To do so, a coercive regularization of the equation is introduced and barrier function arguments are also employed to verify
the equi-continuity of approximate solutions. Furthermore, the Cauchy problem is also studied by using the preceding results
on the Cauchy–Dirichlet problem.
Dedicated to the memory of our friend Kyoji Takaichi.
The research of the first author was partially supported by Waseda University Grant for Special Research Projects, #2004A-366. 相似文献
133.
Summary: Optically active poly[(R)‐ or (S)‐1,4‐bis(2‐(3′,4′‐ethylenedioxy)thienyl)‐2‐benzoic acid 1‐methylheptyl ester] was prepared by an electrochemical technique and characterized by circular dichroism measurements. It was found that the optical activity and optical rotation of the film could be controlled by adjusting the electronic state of the electrochemical process. Polymer films prepared in the oxidized state exhibit a weak Cotton effect, while the reduced polymer film exhibits the expected mirror‐image bisignate Cotton effect in the region of the π–π* transition of the polymer main chain. These results indicate that the main chain itself is chiral in the film state. This procedure has great potential for the preparation of functional electrochromic devices and the improved preparation of durable electrochromic devices based on the good film‐forming properties of the chiral polymer.
134.
Yugo Kuriki Takafusa Yoshioka Mako Kamiya Toru Komatsu Hiroyuki Takamaru Kyohhei Fujita Hirohisa Iwaki Aika Nanjo Yuki Akagi Kohei Takeshita Haruaki Hino Rumi Hino Ryosuke Kojima Tasuku Ueno Kenjiro Hanaoka Seiichiro Abe Yutaka Saito Jun Nakajima Yasuteru Urano 《Chemical science》2022,13(16):4474
Fluorescent probes that can selectively detect tumour lesions have great potential for fluorescence imaging-guided surgery. Here, we established a library-based approach for efficient screening of probes for tumour-selective imaging based on discovery of biomarker enzymes. We constructed a combinatorial fluorescent probe library for aminopeptidases and proteases, which is composed of 380 probes with various substrate moieties. Using this probe library, we performed lysate-based in vitro screening and/or direct imaging-based ex vivo screening of freshly resected clinical specimens from lung or gastric cancer patients, and found promising probes for tumour-selective visualization. Further, we identified two target enzymes as novel biomarker enzymes for discriminating between tumour and non-tumour tissues. This library-based approach is expected to be an efficient tool to develop tumour-imaging probes and to discover new biomarker enzyme activities for various tumours and other diseases.Efficient methodology to develop tumor-imaging fluorescent probes based on screening with our newly constructed probe library for aminopeptidase/protease (380 probes) and clinical samples has been established. 相似文献
135.
136.
An efficient and general synthetic method for various 2-mono- and 2,6-disubstituted γ-pyrones has been developed. This utilizes the -acylation (70–85%) of β-methoxy-α,β-enone lithium enolates by acid chlorides followed by the acid-catalyzed cyclization (>80%) of the resulting enols to γ-pyrones . 相似文献
137.
Abe K Abt I Ahn CJ Akagi T Allen NJ Ash WW Aston D Bacchetta N Baird KG Baltay C Band HR Barakat MB Baranko G Bardon O Barklow T Bazarko AO Ben-David R Benvenuti AC Bienz T Bilei GM Bisello D Blaylock G Bogart JR Bolton T Bower GR Brau JE Breidenbach M Bugg WM Burke D Burnett TH Burrows PN Busza W Calcaterra A Caldwell DO Calloway D Camanzi B Carpinelli M Cassell R Castaldi R Castro A Cavalli-Sforza M Church E Cohn HO Coller JA Cook V Cotton R Cowan RF Coyne DG D'Oliveira A Damerell CJ 《Physical review D: Particles and fields》1996,53(5):R2271-R2275
138.
Dr. Kojiro Fuku Honami Kanai Masanobu Todoroki Nanako Mishima Taisei Akagi Dr. Takashi Kamegawa Prof. Naoki Ikenaga 《化学:亚洲杂志》2021,16(14):1887-1892
Water pollution derived from organic pollutants is one of the global environmental problems. The Fenton reaction using Fe2+ as a homogeneous catalyst has been known as one of clean methods for oxidative degradation of organic pollutants. Here, a layered double hydroxide (Fe2+Al3+-LDH) containing Fe2+ and Al3+ in the structure was used to develop a “heterogeneous” Fenton catalyst capable of mineralizing organic pollutants. We found that sulfate ion (SO42−) immobilized on the Fe2+Al3+-LDH significantly facilitated oxidative degradation (mineralization) of phenol as a model compound of water pollutants to carbon dioxide (CO2) in a heterogeneous Fenton process. The phenol conversion and mineralization efficiency to CO2 reached >99% and ca. 50%, respectively, even with a reaction time of only 60 min. 相似文献
139.
Katsutoshi Tamura Sachio Murakami Yoshimasa Akagi Masato Fukumori Yoshikane Kawasaki 《Journal of solution chemistry》1994,23(2):263-273
Excess enthalpies H
m
E
excess isobaric heat capacities C
p,m
E
, densities, and speeds of sound of hexamethylphosphoric triamide (HMPA)+acetonitrile (AN), + N,N-dimethylformamide (DMF), and + dimethylsulfoxide (DMSO) were measured at 25degrC. H
m
E
=–1200 J-mol–1 for HMPA + AN, –180 J-mol–1 for HMPA + DMF, and 75 J-mol–1 for HMPA + DMSO C
p,m
E
is positive and considerably larger than C
v,m
E
. V
m
E
for HMPA + DMSO was small and changed sign from negative to positive around HMPA mole fraction x=0.6. V
m
E
for the other two mixtures were negative. The excess compressibilities, K
m
E
for the other two mixtures were negative. The excess compressibilities, K
S
E
and K
T
E
were similar to V
m
E
Presented at the Symposium, 76th CSC Congress, Sherbrooke, Quebec, May 30-June 3, 1993, honoring Professor Donald Patterson on the occasion of his 65th birthday. 相似文献
140.
Ultraviolet photodissociation of NHD(2) excited to the fourth overtone state of the NH stretching mode (5nu(NH)) and NH(2)D excited to that of the ND stretching mode (5nu(ND)) has been investigated by using a crossed laser and molecular beams method. Branching ratio between the NH and ND bond dissociations has been determined by utilizing a (2+1) resonance enhanced multiphoton ionization scheme of H and D atoms. For the photolysis of NHD(2) in the 5nu(NH) state, the NH dissociation cross section is 5.1+/-1.4 times as large as the ND dissociation cross section per bond. On the other hand, for the photolysis of NH(2)D in the 5nu(ND) state, the ratio of the NH dissociation cross section per bond to the ND dissociation cross section decreases to 0.68+/-0.16. In comparison with the branching ratios for the photolysis of vibrationally unexcited NH(2)D and NHD(2), the present results indicate that the excitation of the NH stretching mode enhances the NH dissociation with ca. two times larger NH/ND branching ratio, whereas the excitation of the ND stretching mode results in the preferential ND dissociation with ca. 3-4 times larger ND/NH branching ratio than that for the vibrational ground states. The mechanism of the bond-selective enhancement has been discussed in terms of the energetics and dynamics of wave packet. 相似文献