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61.
Lorien J. Parker Louis C. Italiano Craig J. Morton Nancy C. Hancock David B. Ascher Jade B. Aitken Hugh H. Harris Pablo Campomanes Ursula Rothlisberger Anastasia De Luca Mario Lo Bello Wee Han Ang Paul J. Dyson Michael W. Parker 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(28):7705-7705
62.
W. Franklin Gilmore David W. Morton 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3-4):185-187
Abstract Stabilized carbanions such as the α-carbanions of carboxylic acid esters react with sulfamoyl chlorides by nucleophilic displacement at chlorine which results in chlorination of the carbanion. Thus direct sulfamoylation of these carbanions with sulfamoyl chlorides fails. Conversion of sulfamoyl chlorides to N-sulfonylamines followed by addition of carbanions at -78°C results in sulfamoylation of the carbanion. The method has not been successful with carbanions from diethyl acetamidomalonate and ethyl diphenylacetate. 相似文献
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64.
Wee Han Ang Dr. Lorien J. Parker Anastasia De Luca Lucienne Juillerat‐Jeanneret Dr. Craig J. Morton Dr. Mario Lo Bello Prof. Michael W. Parker Prof. Paul J. Dyson Prof. 《Angewandte Chemie (International ed. in English)》2009,48(21):3854-3857
Double trouble : A hybrid organic–inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active‐site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.
65.
66.
By employing Senanayake's oxathiazolidine-2-oxide reagent, a collection of sulfinamides was prepared and provided the first examples of sulfinamides promoting the allylation of benzaldehyde and N-benzoylhydrazones with allyltrichlorosilane. The optimum sulfinamide-derived Lewis base promoter displays comparable activity to the best sulfinyl-based Lewis bases reported. The use of bis-sulfoxides is also discussed. 相似文献
67.
68.
Morton E. Gurtin Terrance D. Ralston 《International Journal of Solids and Structures》1974,10(9):933-943
This paper establishes the convergence of the continuous-time Galerkin technique as applied to quasi-static, linear viscoelasticity. 相似文献
69.
Sarah R. Dennison Leslie H.G. Morton Andrea J. Shorrocks Frederick Harris David A. Phoenix 《Colloids and surfaces. B, Biointerfaces》2009,68(2):225-230
Aurein 2.5 (GLFDIVKKVVGAFGSL-NH2) is an uncharacterised antimicrobial peptide. At an air/water interface, it exhibited strong surface activity (maximal surface pressure 25 mN m−1) and molecular areas consistent with the adoption of α-helical structure orientated either perpendicular (1.72 nm2 molecule−1) or parallel (3.6 nm2 molecule−1) to the interface. Aurein 2.5 was strongly antibacterial, exhibiting a minimum inhibitory concentration (MIC) of 30 μM against Bacillus subtilis and Escherichia coli. The peptide induced maximal surface pressure changes of 9 mN m−1 and 5 mN m−1, respectively, in monolayers mimicking membranes of these organisms whilst compression isotherm analysis of these monolayers showed ΔGMix > 0, indicating destabilisation by Aurein 2.5. These combined data suggested that toxicity of the peptide to these organisms may involve membrane invasion via the use of oblique orientated α-helical structure. The peptide induced strong, comparable maximal surface changes in monolayers of DOPG (7.5 mN m−1) and DOPE monolayers (6 mN m−1) suggesting that the membrane interactions of Aurein 2.5 were driven by amphiphilicity rather than electrostatic interaction. Based on these data, it was suggested that the differing ability of Aurein 2.5 to insert into membranes of B. subtilis and E. coli was probably related to membrane-based factors such as differences in lipid packing characteristics. The peptide was active against both sessile E. coli and Staphylococcus aureus with an MIC of 125 μM. The broad-spectrum antibacterial activity and non-specific modes of membrane action used by Aurein 2.5 suggested use as an anti-biofilm agent such as in the decontamination of medical devices. 相似文献
70.
This paper presents a simple, self‐contained account of Gårding's theory of hyperbolic polynomials, together with a recent convexity result of Bauschke‐Güler‐Lewis‐Sendov and an inequality of Gurvits. This account begins by establishing some new results. The first concerns the existence of a pointwise arrangement of the eigenvalues so that they become global real analytic functions. The second asserts that the associated “branches” are independent of the choice of hyperbolic direction. © 2013 Wiley Periodicals, Inc. 相似文献