The influence of extraneous sounds on the perceptual estimation of first-formant frequency in vowels

The contribution of extraneous sounds to the perceptual estimation of the first-formant (F1) frequency of voiced vowels was investigated using a continuum of vowels perceived as changing from/I/to/epsilon/as F1 was increased. Any phonetic effects of adding extraneous sounds were measured as a change in the position of the phoneme boundary on the continuum. Experiments 1-5 demonstrated that a pair of extraneous tones, mistuned from harmonic values of the fundamental frequency of the vowel, could influence perceived vowel quality when added in the F1 region. Perceived F1 frequency was lowered when the tones were added on the lower skirt of F1, and raised when they were added on the upper skirt. Experiments 6 and 7 demonstrated that adding a narrow-band noise in the F1 region could produce a similar pattern of boundary shifts, despite the differences in temporal properties and timbre between a noise band and a voiced vowel. The data are interpreted using the concept of the harmonic sieve [Duifhuis et al., J. Acoust. Soc. Am. 71, 1568-1580 (1982)]. The results imply a partial failure of the harmonic sieve to exclude extraneous sounds from the perceptual estimation of F1 frequency. Implications for the nature of the hypothetical harmonic sieve are discussed.     

Ueber die antagonistische Wirkung der Neutralsalze auf die Quellung des Fibrins in Säuren und Alkalien

Ohne Zusammenfassung     

Zur Analyse von Eisen -und Stahl

Ohne Zusammenfassung     

Zur Analyse des Neusilbers

Ohne Zusammenfassung     

Preparation of enediyne-crosslinked networks and their reactivity under thermal and mechanical conditions

The COGEF technique (COnstrained Geometries simulating External Force) was used to investigate the effects of macroscopic forces on cyclic enediynes, which can undergo Bergman Cyclization (BC). Because the forces needed to activate BC were found to be less than the forces needed for chain scission in polymer backbones, the calculations suggest that enediynes are potentially useful mechanophores. Three enediynes studied computationally were synthesized. The thermal BC reactions for these compounds were studied by DSC and found to be consistent with the predicted thermal sensitivity based on known substituent effects. However, upon incorporation of the enediynes into a polymer matrix as crosslinks, no definitive mechanical activation was observed, and conclusions about the stress-sensitivity of enediynes were unable to be drawn. Model studies suggest that insufficient force was applied to the crosslinks for mechanical activation to be observable by DSC.     

Factors affecting thresholds for sinusoidal signals in narrow-band maskers with fluctuating envelopes

When a signal is higher in frequency than a narrow-band masker, thresholds are lower when the masker envelope fluctuates than when it is constant. This article investigates the cues used to achieve the lower thresholds, and the factors that influence the amount of threshold reduction. In experiment I the masker was either a sinusoid (constant envelope) or a pair of equal-amplitude sinusoids (fluctuating envelope) centered at the same frequency as the single sinusoid (250, 1000, 3000, or 5275 Hz). The signal frequency was 1.8 times the masker frequency. At all center frequencies, thresholds were lower for the two-tone masker than for the sinusoidal masker, but the effect was smaller at the highest and lowest frequencies. The reduced effect at high frequencies is attributed to the loss of a cue related to phase locking in the auditory nerve. The reduced effect at low frequencies can be partly explained by reduced slopes of the growth-of-masking functions. In experiment II the masker was a sinusoid amplitude modulated at an 8-Hz rate. Masker and signal frequencies were the same as for the first experiment. Randomizing the modulation depth between the two halves of a forced-choice trial had no effect on thresholds, indicating that changes in modulation depth are not used as a cue for signal detection. Thresholds in the modulated masker were higher than would be predicted if they were determined only by the masker level at minima in the envelope, and the threshold reduction produced by modulating the master envelope was less at 250 Hz than at higher frequencies. Experiments III and IV reveal two factors that contribute to the reduced release from masking at low frequencies: The rate of increase of masked threshold with decreasing duration is greater at 250 Hz than at 1000 Hz; the amount of forward masking, relative to simultaneous masking, is greater at 250 Hz than at 1000 Hz. The results are discussed in terms of the relative importance of across-channel cues and within-channel cues.     

Frequency discrimination of complex tones with overlapping and non-overlapping harmonics

These experiments address the following issues. (1) When two complex tones contain different harmonics, do the differences in timbre between them impair the ability to discriminate the pitches of the tones? (2) When two complex tones have only a single component in common, and that component is the most discriminable component in each tone, is the frequency discrimination of the component affected by differences in residue pitch between the two tones? (3) How good is the pitch discrimination of complex tones with no common components when each tone contains multiple harmonics, so as to avoid ambiguity of pitch? (4) Is the pitch discrimination of complex tones with common harmonics impaired by shifting the component frequencies to nonharmonic values? In all experiments, frequency difference limens (DLCs) were measured for multiple-component complex tones, using an adaptive two-interval, two-alternative, forced-choice task. Three highly trained subjects were used. The main conclusions are as follows. (1) When two tones have the first six harmonics in common, DLCs are larger when the upper harmonics are different than when the upper harmonics are in common or are absent. It appears that differences in timbre impair DLCs. (2) Discrimination of the frequency of a single common partial in two complex tones is worse when the two tones have different residue pitches than when they have the same residue pitch. (3) DLCs for complex tones with no common harmonics are generally larger than those for complex tones with common harmonics. For the former, large individual differences occur, probably because subjects are affected differently by differences in timbre. (4) DLCs for harmonic complex tones are smaller than DLCs for complex tones in which the components are mistuned from harmonic values. This can probably be attributed to the less distinct residue pitch of the inharmonic complexes, rather than to reduced discriminability of partials. Overall, the results support the idea that DLCs for complex tones with common harmonics depend on residue pitch comparisons, rather than on comparisons of the pitches of partials.     

Detection and discrimination of spectral peaks and notches at 1 and 8 kHz

The ability of subjects to detect and discriminate spectral peaks and notches in noise stimuli was determined for center frequencies fc of 1 and 8 kHz. The signals were delivered using an insert earphone designed to produce a flat frequency response at the eardrum for frequencies up to 14 kHz. In experiment I, subjects were required to distinguish a broadband reference noise with a flat spectrum from a noise with either a peak or a notch at fc. The threshold peak height or notch depth was determined as a function of bandwidth of the peak or notch (0.125, 0.25, or 0.5 times fc). Thresholds increased with decreasing bandwidth, particularly for the notches. In experiment II, subjects were required to detect an increase in the height of a spectral peak or a decrease in the depth of a notch as a function of bandwidth. Performance was worse for notches than for peaks, particularly at narrow bandwidths. For both experiments I and II, randomizing (roving) the overall level of the stimuli had little effect at 1 kHz, but tended to impair performance at 8 kHz, particularly for notches. Experiments III-VI measured thresholds for detecting changes in center frequency of sinusoids, bands of noise, and spectral peaks or notches in a broadband background. Thresholds were lowest for the sinusoids and highest for the peaks and notches. The width of the bands, peaks, or notches had only a small effect on thresholds. For the notches at 8 kHz, thresholds for detecting glides in center frequency were lower than thresholds for detecting a difference in center frequency between two steady sounds. Randomizing the overall level of the stimuli made frequency discrimination of the sinusoids worse, but had little or no effect for the noise stimuli. In all six experiments, performance was generally worse at 8 kHz than at 1 kHz. The results are discussed in terms of their implications for the detectability of spectral cues introduced by the pinnae.     

Evaluation of a Gelatin-Modified Poly(ε-Caprolactone) Film as a Scaffold for Lung Disease

Lung transplantation is a necessary step for the patients with the end stage of chronic obstructive pulmonary disease. The use of artificial lungs is a promising alternative to natural lung transplantation which is complicated and is restricted by low organ donations. For successful lung engineering, it is important to choose the correct combination of specific biological cells and a synthetic carrier polymer. The focus of this study was to investigate the interactions of human lung epithelial cell line NCl-H292 that is involved in lung tissue development with the biodegradable poly(ε-caprolactone) before and after its chemical modification to evaluate potential for use in artificial lung formation. Also, the effect of polymer chemical modification on its mechanical and surface properties has been investigated. The poly(ε-caprolactone) surface was modified using aminolysis followed by immobilization of gelatin. The unmodified and modified polymer surfaces were characterized for roughness, tensile strength, and NCl-H292 metabolic cell activity. The results showed for the first time the possibility for NCI-H292 cells to adhere on this polymeric material. The resazurin assay showed that the metabolic activity at 24?h postseeding of 80% in the presence of the unmodified and greater than 100% in the presence of the modified polymer was observed. The roughness of the poly(ε-caprolactone) increased from 4 to 26?nm and the film strength increased from 0.01 to 0.045 kN when the material was chemically modified. The results obtained to date show potential for using modified poly(ε-caprolactone) as a scaffold for lung tissue engineering.