IR-Spektren von deuteriertem Poly(methylmethacrylat), (-CD2C(CH3)COOCH3)n-

Ohne Zusammenfassung     

<Emphasis Type="Italic">N</Emphasis>-arachidonoyl glycine,an abundant endogenous lipid,potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

Background  

Microglia provide continuous immune surveillance of the CNS and upon activation rapidly change phenotype to express receptors that respond to chemoattractants during CNS damage or infection. These activated microglia undergo directed migration towards affected tissue. Importantly, the molecular species of chemoattractant encountered determines if microglia respond with pro- or anti-inflammatory behaviour, yet the signaling molecules that trigger migration remain poorly understood. The endogenous cannabinoid system regulates microglial migration via CB₂ receptors and an as yet unidentified GPCR termed the 'abnormal cannabidiol' (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of the phytocannabinoid cannabidiol (CBD) and is inactive at CB₁ or CB₂ receptors, but functions as a selective agonist at this G_i/o-coupled GPCR. N-arachidonoyl glycine (NAGly) is an endogenous metabolite of the endocannabinoid anandamide and acts as an efficacious agonist at GPR18. Here, we investigate the relationship between NAGly, Abn-CBD, the unidentified 'Abn-CBD' receptor, GPR18, and BV-2 microglial migration.     

Bragg grating writing through the polyimide coating of high NA optical fibres with femtosecond IR radiation

Bragg gratings are written with ultrafast 800 nm radiation and a phase mask through the polyimide polymer coatings of commercially available high NA fibres that are both unloaded and loaded with high pressure hydrogen gas. For polyimide coated fibres with very high germanium core concentrations, index modulations greater than 1 × 10⁻⁴ are induced. Stable core index modulations 60% of their original value were present after 115 h at 500 °C.     

Oriented action of some solid substrates to liquid crystal layer

The orienting action of three types of layers on liquid crystal is investigated. Homogeneous orientation of the liquid crystal layer is obtained under the action of a transparent conductive SnO₂ film and carbon film. Such an orientation is achieved with gelatin films as well. Homeotropic orientation of the liquid crystal can be also obtained by exposing the latter to ion bombardment with Ar ions.     

Pecularities of the thermomechanical behaviour of ultra-high molecular weight linear polyethylene and its blends with linear polyethylene of normal molecular weight

Ultra-high molecular weight polyethylene UHMWPE (M _w=4 · 10⁶,I _s=O g/ 10 min), high density polyethylene of normal molecular weight NMWPE (I _s= 4.8 g/10 min) and their blends have been investigated by means of thermomechanical loading in constant and impulse regime. It has been established that after melting, NMWPE passes to a viscous-liquid state. After melting at 138 °C UHMWPE passes to a high-elastic state. The transition of UHMWPE to a viscous-liquid state takes place at temperatures higher than 180 °C and is accompanied by a high-elastic reversible deformation. The blends of UHMWPE with 10 and 20 mass % of NMWPE show a plateau on the thermomechanical curves, corresponding to a high-elastic state, in a shorter temperature range where the deformation is greater. The blends containing the higher percent of NMWPE show thermomechanical curves lacking such a plateau. All blends are characterized by a singular thermomechanically defined temperature of melting, which increases with increase of UHMWPE content. The existence of the high-elastic state in the curves of UHMWPE and its blends containing NMWPE less than 30 mass % above their melting temperatures is explained by the high degree of physical crosslinking of UHMWPE.     

Modification of surface morphology and lattice order in nanocrystalline ZnO thin films prepared by spin-coating sol–gel method

Journal of Sol-Gel Science and Technology - Halloysite Nanotubes (HNTs) with large surface/volume ratio and rich reactive groups are incorporated into Fe-based MOF aerogel to develop MOF(Fe)/HNTs...     

Generation of pure two-beam interference grating structures in an optical fiber with a femtosecond infrared source and a phase mask

Fiber Bragg gratings were fabricated in all-silica core fiber by focusing 125-fs 800-nm pulses with an 80-mm lens through a phase mask with 4.28-microm pitch onto a fiber sample. When the phase-mask-fiber separation was 5 mm the observed structure was clearly the result of two-beam interference between the +/- 1 orders. The elimination of the remaining 9 orders is a consequence of the walk-off experienced by the mask orders and the short duration of the femtosecond pulse. This effect is unique to the fabrication of Bragg gratings with femtosecond sources and would not be observed with a longer pulse duration or incoherent UV sources.     

Hydrogen loading for fiber grating writing with a femtosecond laser and a phase mask

The threshold for the fabrication of fiber Bragg gratings with ultrafast 800-nm radiation and a phase mask was studied in SMF-28 and all-silica core fiber by use of 125-fs pulses. High-pressure molecular hydrogen loading (H2 loading) was observed to significantly lower the grating writing threshold in standard Ge-doped telecommunication fiber. No reduction was observed with all-silica core fiber. The index change appeared to be confined to the Ge-doped core region of the fiber. Gratings in H2-loaded SMF-28 had thermal annealing behavior similar to UV-induced gratings. Unlike UV-induced H2-loaded gratings, no absorption associated with Ge-OH defect formation was observed.