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81.
Silvestro L Gheorghe M Iordachescu A Ciuca V Tudoroniu A Rizea Savu S Tarcomnicu I 《Analytical and bioanalytical chemistry》2011,401(3):1023-1034
A new sensitive and fast quantitative analytical method for the simultaneous determination of clopidogrel, its main metabolite
clopidogrel carboxylic acid, and the newly described acyl glucuronide metabolite, in human plasma samples, is presented. The
analytical procedures (plasma storage, handling, and extract storage in the autosampler) were optimized in order to avoid
back-conversion; a known drawback in measurements of clopidogrel. Clopidogrel acyl glucuronide was confirmed as a major source
of back-conversion to the parent drug in the presence of methanol, and thorough stability experiments were carried out to
find the most appropriate conditions for an accurate analysis of clopidogrel and the two metabolites. The method was validated
by assessing selectivity, sensitivity, linearity, accuracy, and precision for all three analytes, in accordance to Food and
Drug Administration guidelines. Spiked quality controls in plasma as well as incurred samples were used to verify back-conversion
in the selected conditions, with results meeting European Medicines Agency acceptance criteria (concentrations within 80–120%
of the first reading). The method was then applied to a pharmacokinetic study, and for the first time, a pharmacokinetic curve
of clopidogrel acyl glucuronide in human plasma is presented. The concentrations ranged up to 1,048.684 ng/mL, with a mean
of 470.268 ng/mL, while clopidogrel had a mean C
max of 1.348 ng/mL; these orders of magnitude show how much the back-conversion of this metabolite may influence clopidogrel
quantification if it is not properly controlled. 相似文献
82.
Rodica Olar Mihaela Badea Dana Marinescu Larisa Calu Cristina Bucur 《Journal of Thermal Analysis and Calorimetry》2011,105(2):571-575
Novel complexes of type [M2LCl4]·nH2O ((1) M:Ni, n = 5; (2) M:Cu, n = 0 and (3) M:Zn, n = 2; L: ligand resulted from 1,2-phenylenediamine, 3,6-diazaoctane-1,8-diamine and formaldehyde template condensation) were
synthesised and characterised. The features of complexes have been assigned from microanalytical, IR and UV–Vis data. The
thermal analyses have evidenced the thermal intervals of stability and also the thermodynamic effects that accompany them.
Processes as water or hydrochloric acid elimination as well as oxidative degradation of the organic ligand were observed.
Complexes display a different thermal behaviour as result of dissimilar chemical interaction of metal ions with chloride anions.
The final product of decomposition was metal(II) oxide as powder X-ray diffraction indicated. 相似文献
83.
Mihaela Badea Rodica Olar Valentina Uivarosi Dana Marinescu Victoria Aldea Stefania Felicia Barbuceanu George Mihai Nitulescu 《Journal of Thermal Analysis and Calorimetry》2011,105(2):559-564
Two new complexes having general formula VOL2·nH2O [(1) L: 5-hydroxyflavone, n = 1; (2) L: chrysin, n = 4] were synthesized and characterized. Based on IR and electronic data we concluded that studied flavones act as bidentate
ligands in complexes with metallic ion coordinated in a square-pyramidal stereochemistry. The thermal analysis (TG, DTA) elucidated
the composition and also the number and nature of the water molecules. The thermal behavior also indicated strong interactions
between oxovanadium (IV) and these oxygen donor ligands. 相似文献
84.
Stefanie Schwamborn Dr. Leonard Stoica Prof. Dr. Wolfgang Schuhmann 《Chemphyschem》2011,12(9):1741-1746
PtAg bimetallic nanoparticles for oxygen reduction reaction (ORR) in alkaline media were prepared by pulse electrodeposition (PED). During PED the reduction of Ag+ ions predominates, thus an increased Ag content in the co‐deposit is accomplished. The mechanism for this anomalous co‐deposition was elucidated by potential pulse experiments, which revealed that nuclei formation mainly occurs via the reduction of Pt2+ ions. The growth of the particles is diffusion controlled leading to the formation of a Ag shell covering a PtAg alloyed region. However, the shell is not growing homogeneously on the PtAg alloy. Hence, regions of the PtAg alloy are exposed, which exhibit an enhanced ORR activity compared to a pure Ag surface. 相似文献
85.
Let V
n
be the SL2-module of binary forms of degree n and let V = Vn1 ???Vnp V = {V_{{n_1}}} \oplus \cdots \oplus {V_{{n_p}}} . We consider the algebra
R = O(V)\textS\textL2 R = \mathcal{O}{(V)^{{\text{S}}{{\text{L}}_2}}} of polynomial functions on V invariant under the action of SL2. The measure of the intricacy of these algebras is the length of their chains of syzygies, called homological dimension hd R. Popov gave in 1983 a classification of the cases in which hd R ≤ 10 for a single binary form (p = 1) or hd R ≤ 3 for a system of two or more binary forms (p > 1). We extend Popov’s result and determine for p = 1 the cases with hd R ≤ 100, and for p > 1 those with hd R ≤ 15. In these cases we give a set of homogeneous parameters and a set of generators for the algebra R. 相似文献
86.
M. Petrascu A. Constantinescu I. Cruceru M. Giurgiu A. Isbasescu H. Petrascu C. Bordeanu S. Serban V. Stoica I. Tanihata W. G. Lynch V. L. Lyuboshits V. V. Lyuboshits 《Physics of Atomic Nuclei》2006,69(7):1261-1266
The preemission of neutrons from 11Li halo nuclei is considered. The present problems of investigation of 11Li halo nucleus structure by means of the C
nn correlation function are briefly presented. The influence of the target screening on the halo neutron preemission is described.
It is shown that, owing to the diminishing of the screening effect, the yield of preemission neutron pairs is expected to
be much larger in the case of 12C than in the case of Si target. It is shown that a new experiment on a 12C target will allow one to solve the standing problems of C
nn and to test experimentally a recent new theory of C
nn.
The text was submitted by the authors in English. 相似文献
87.
Mihaela Ginj 《Tetrahedron letters》2005,46(16):2821-2824
It is now well established that the biological effects of Auger-emitting radionuclides are critically dependent on their subcellular location. Therefore, for their use in molecular imaging and targeted radionuclide therapy, attempts should be made to increase the nuclear specificity of the carriers. In the present paper the synthesis of novel trifunctional somatostatin derivatives containing a nuclear localization motif is described. These derivatives of [DOTA0, Tyr3]-octreotide (DOTATOC, DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) were obtained in high yields using Fmoc peptide synthesis in solid and in solution phase. 相似文献
88.
George Stoica 《Journal of Mathematical Analysis and Applications》2005,308(2):759-763
We study Davis-type theorems on the moderate deviation probabilities of martingale differences with finite pth moments (1?p<∞). We prove that Davis' first result holds if p>4 and fails if 1?p<4, and Davis' second result holds if p>2 and fails if 1?p<2. 相似文献
89.
Laurent?DenisEmail author Anis?Matoussi Lucretiu?Stoica 《Probability Theory and Related Fields》2005,133(4):437-463
In this paper we prove Lp estimates (p≥2) for the uniform norm of the paths of solutions of quasilinear stochastic partial differential equations (SPDE) of parabolic
type. Our method is based on a version of Moser's iteration scheme developed by Aronson and Serrin in the context of non-linear
parabolic PDE. 相似文献
90.
Tao C Deselnicu M Fan H Mukarakate C Ionescu I Reid SA 《Physical chemistry chemical physics : PCCP》2006,8(6):707-713
To further investigate the Renner-Teller (RT) effect and barriers to linearity and dissociation in the simplest singlet carbene, we recorded fluorescence excitation spectra of bands involving the pure bending levels 2(n)(0) with n = 0-9 and the combination states 1(1)(0)2(n)(0) with n = 1-8 and 2(n)(0)3(1)(0) with n = 0-5 in the A(1)A'<-- X(1)A' system of CDF, in addition to some weak hot bands. The spectra were measured under jet-cooled conditions using a pulsed discharge source, and rotationally analyzed to yield precise values for the band origins and rotational constants; fluorescence lifetimes were also measured to probe for lifetime lengthening effects due to the RT interaction. The derived A state parameters are compared with previous results for CHF and with predictions of ab initio electronic structure theory. The approach to linearity in the A state is evidenced in a sharp increase in the A rotational constant with bending excitation, and a minimum in the vibrational intervals near 2(9). A fit of the vibrational intervals for the pure bending levels yields an A state barrier to linearity in good agreement both with that previously derived for CHF and ab initio predictions. From the spectra and lifetime measurements, the onset of extensive RT perturbations is found to occur at a higher energy than in CHF, consistent with the smaller A constant. 相似文献