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排序方式: 共有155条查询结果,搜索用时 0 毫秒
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Shaw NM Blanis D Bodek A Budd H Coombes R Eno S Fry CA Harada H Ho YH Kim YK Kumita T Mori T Olsen SL Sill A Thorndike EH Ueno K Zheng HW Imlay R Kirk P Lim J McNeil RR Metcalf W Myung SS Cheng CP Gu P Li J Li YK Mao ZP Xu YT Zhu YC Abashian A Gotow K Hu K Low EH Mattson ME Naito F Piilonen L Sterner KL Lusin S Rosenfeld C Wang AT Wilson S Frautschi M Kagan H Kass R Trahern CG Breedon RE Kim GN Ko W Lander RL Maeshima K Malchow RL Smith JR Sparks K Williams MC Abe K Fujii Y Higashi Y Kim SK 《Physical review letters》1989,63(13):1342-1345
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Auerbach LB Burman RL Caldwell DO Church ED Cochran AK Donahue JB Fazely AR Garvey GT Gunasingha RM Imlay RL Kahrimanis G Louis WC Majkic R Malik A McIlhany KL Metcalf WJ Mills GB Rupnik D Sandberg VD Smith D Somodi RF Stancu I Strossman WD Sung M Tayloe R VanDalen GJ Vernon W Wadia N White DH Yellin S Yi H;LSND Collaboration 《Physical review letters》2004,92(9):091801
We observe a net beam excess of 8.7+/-6.3(stat)+/-2.4(syst) events, above 160 MeV, resulting from the charged-current reaction of nu(micro) and/or nu;(mu) on C and H in the LSND detector. No beam-related muon background is expected in this energy regime. Within an analysis framework of pi(0)-->nu(mu)nu;(mu), we set a direct upper limit for this branching ratio of Gamma(pi(0)-->nu(mu)nu;(mu))/Gamma(pi(0)-->all)<1.6 x 10(-6) at 90% confidence level. 相似文献
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CM Silva MF Duarte ML Mira MH Florêncio K Versluis AJ Heck 《Rapid communications in mass spectrometry : RCM》1999,13(12):1098-1103
Fast atom bombardment, combined with high-energy collision-induced tandem mass spectrometry, has been used to investigate gas-phase metal-ion interactions with captopril, enalaprilat and lisinopril, all angiotensin-converting enzyme inhibitors.Suggestions for the location of metal-binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
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M. Metcalf G. Neuhofer F. Niebergall M. Regler H. Stier K. Winter
J. J. Aubert
X. De Bouard V. Lepeltier L. Massonnet H. Pessard M. Vivargent T. R. Willitts M. YvertW. Bartl
M. Steuer 《Physics letters. [Part B]》1972,40(6):703-707The time-dependence of the decay rate of initially pure K0 into the final state (π+π−π0) has been studied in search for the decay kS0→π+π−π0. No evidence is found in a sample of 384 observed events. The ratio of the CP -violating KS0 amplitude and the KL0 amplitude is η+−0 = (0.13−0.20+0.17) + i(0.17−0.26+0.27); the ratio of the CP-conserving KS0 amplitude and the KL0 amplitude is < 0.4. The energy dependence of the K0→π+π−π0 matrix element is found to be a+−0 = −0.31 ± 0.03. 相似文献
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Hsuan-Yin Lan-Hargest John D. Elliott Drake S. Eggleston Brian W. Metcalf 《Tetrahedron letters》1987,28(52):6557-6560
Photolysis of the steroidal dienol triflate
in pyridine solution using a medium pressure mercury lamp leads to the formation of 6β-trifluoromethyl enone
in 78% yield. The structure of compound
was confirmed by x-ray analysis. 相似文献
10.
Nandan Haloi Archit Kumar Vasan Emily J. Geddes Arjun Prasanna Po-Chao Wen William W. Metcalf Paul J. Hergenrother Emad Tajkhorshid 《Chemical science》2021,12(45):15028
Antibiotic resistance of Gram-negative bacteria is largely attributed to the low permeability of their outer membrane (OM). Recently, we disclosed the eNTRy rules, a key lesson of which is that the introduction of a primary amine enhances OM permeation in certain contexts. To understand the molecular basis for this finding, we perform an extensive set of molecular dynamics (MD) simulations and free energy calculations comparing the permeation of aminated and amine-free antibiotic derivatives through the most abundant OM porin of E. coli, OmpF. To improve sampling of conformationally flexible drugs in MD simulations, we developed a novel, Monte Carlo and graph theory based algorithm to probe more efficiently the rotational and translational degrees of freedom visited during the permeation of the antibiotic molecule through OmpF. The resulting pathways were then used for free-energy calculations, revealing a lower barrier against the permeation of the aminated compound, substantiating its greater OM permeability. Further analysis revealed that the amine facilitates permeation by enabling the antibiotic to align its dipole to the luminal electric field of the porin and form favorable electrostatic interactions with specific, highly-conserved charged residues. The importance of these interactions in permeation was further validated with experimental mutagenesis and whole cell accumulation assays. Overall, this study provides insights on the importance of the primary amine for antibiotic permeation into Gram-negative pathogens that could help the design of future antibiotics. We also offer a new computational approach for calculating free-energy of processes where relevant molecular conformations cannot be efficiently captured.A rapid pathway sampling method combining Monte Carlo and graph theory, developed to describe permeation pathways through outer membrane porins, can distinguish between structurally similar analogs with different permeabilities. 相似文献