全文获取类型
收费全文 | 849篇 |
免费 | 1篇 |
国内免费 | 4篇 |
专业分类
化学 | 623篇 |
晶体学 | 6篇 |
力学 | 29篇 |
数学 | 91篇 |
物理学 | 105篇 |
出版年
2023年 | 7篇 |
2022年 | 7篇 |
2021年 | 7篇 |
2020年 | 7篇 |
2019年 | 4篇 |
2016年 | 4篇 |
2015年 | 7篇 |
2014年 | 6篇 |
2013年 | 31篇 |
2012年 | 36篇 |
2011年 | 53篇 |
2010年 | 22篇 |
2009年 | 17篇 |
2008年 | 47篇 |
2007年 | 61篇 |
2006年 | 50篇 |
2005年 | 49篇 |
2004年 | 63篇 |
2003年 | 44篇 |
2002年 | 36篇 |
2001年 | 8篇 |
2000年 | 5篇 |
1999年 | 11篇 |
1998年 | 7篇 |
1997年 | 12篇 |
1996年 | 12篇 |
1995年 | 11篇 |
1994年 | 10篇 |
1993年 | 9篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 16篇 |
1989年 | 10篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1985年 | 8篇 |
1984年 | 21篇 |
1983年 | 10篇 |
1982年 | 17篇 |
1981年 | 5篇 |
1980年 | 12篇 |
1979年 | 10篇 |
1978年 | 18篇 |
1977年 | 13篇 |
1976年 | 13篇 |
1975年 | 8篇 |
1974年 | 8篇 |
1973年 | 5篇 |
1968年 | 3篇 |
排序方式: 共有854条查询结果,搜索用时 0 毫秒
51.
52.
DNA酶中的G-四链体-血红素(G4-hemin)DNA酶结构具有较高的设计性和化学稳定性,因此格外受研究者关注.G-平面作为辅酶因子hemin的结合位点,不仅提供大π平面与hemin结合,而且其平面上的G碱基还可以充当近端配位基团与hemin进行配位.因此,研究G-平面完整性在G4-DNA酶体系中的作用具有重要意义.... 相似文献
53.
54.
This work describes the synthesis of certain nucleoside synthons which are necessary in order to obtain oligoxylonucleotides. The utilization of a non-symmetrically substituted xyloside substituted at the 2-position permits one to obtain, in satisfactory yields, the described nucleoside which is conveniently protected. All of the compounds described have been fully characterized using the usual analytical methods. 相似文献
55.
Long Lin Xiaogang Peng Emilie Voirin Bertrand Donnio Mircea V. Rastei Bertrand Vileno Jean-Louis Gallani 《Helvetica chimica acta》2023,106(3):e202200165
The magnetic properties of noble-metal nanoparticles are a puzzling phenomenon, tentatively often explained as a size effect or a ligand effect. Many experimental studies performed to date have attempted to vary these readily available parameters without reaching a definitive conclusion. In an attempt at better understanding the role of core crystallinity on these magnetic properties, we have compared the behavior of silver nanoparticles, which were either single-crystalline or multi-twinned, of almost identical sizes and with the same ligand coating. Our results indicate that single-crystalline nanoparticles tend to behave as classical paramagnetic materials, whereas multi-twinned ones exhibit a combination of para- and ferro-magnetic behaviors. Our hypothesis is that lattice defects within the core bear magnetic moments which couple through conduction electrons, with dipolar interactions also playing a local and macroscopic role. 相似文献
56.
Here we redesigned the branches of polyamidoamine (PAMAM) dendrimers by moving the amide carbonyl group on the other side of the amide nitrogen atom, transforming the β-alaninyl-amidoethylamine branch, which easily undergoes retro-Michael reactions and renders PAMAMs intrinsically unstable, into a more stable glycyl-amidopropylamine branch. The resulting inverse PAMAM (i-PAMAM) dendrimers have the same carbon framework as PAMAMs and only differ by the position of the carbonyl group. In contrast to PAMAMs which are prepared in solution and are difficult to purify, we synthesize i-PAMAMs using high-temperature solid-phase peptide synthesis by iterative coupling and deprotection of the commercially available N,N-bis(N′-Fmoc-3-aminopropyl)glycine and purify them preparative reverse phase HPLC. Our i-PAMAM dendrimers show no detectable degradation over time. We demonstrate this new class of dendrimers with the synthesis of antimicrobial dendrimers with potent yet non-membrane disruptive activities against both Gram-negative and Gram-positive bacteria. 相似文献
57.
An amperometric sensor for the detection of ethanol has been designed. The sensing layer consists of alcohol dehydrogenase (ADH), NADH oxidase and NAD+-dextran, entrapped together in a matrix of poly(vinyl alcohol) bearing styrylpyridinium groups (PVA-SbQ). Measurements have been carried out at a low oxidizing potential (equivalent to 250 mV vs. SCE) to detect hexacyanoferrate(II), thus avoiding interferences due to presence of oxidizable compounds in real samples. The influence of the amount of polymer, enzymes and coenzyme in the sensing layer on the sensor sensitivity, linear range and operational stability has been studied. The sensitivity was close to 2 mA 1 mol−1, with a linear range 3 × 10−7 −2 × 10−4M and a response time <2 min. Good operational stability was observed, allowing more than 40 reproducible assays without NAD+ addition. Alcoholic beverages were analysed with the use of sensor and the results showed good correlation with those obtained using a standard spectrophotometric procedure. 相似文献
58.
The predictions of a nonequilibrium schematic mode-coupling theory developed to describe the nonlinear rheology of soft glassy materials have been numerically tested in a sheared binary Lennard-Jones mixture. In this Letter, we focus on the existence, behavior, and properties of an effective temperature T(eff) for the slow modes of the fluid, as defined from a generalized fluctuation-dissipation theorem. New, simple experimental protocols to access T(eff) are proposed, and one such experiment is numerically performed. Our results give strong support to the thermodynamic interpretation of T(eff) and make it experimentally accessible in a very direct way. 相似文献
59.
Marcel Baiwir Gabriel Llabrs Lon Christiaens Jean-Louis Piette 《Magnetic resonance in chemistry : MRC》1982,18(1):33-37
The 1H, 13C and 77Se chemical shifts have been measured for mononitrobenzo[ b ]selenophenes. For the homocyclic nuclei, the observed 1H- and 13C-values calculated from the empirical increments of nitrobenzene. Anomalous effects are observed in the 2- and 3-substituted derivatives and the nature of the Se? NO2 interactions in the former is discussed. 77Se chemical shifts of the 4-, 5- and 7-nitro derivatives are approximately correlated with the CNDO calculated electron densities; they also compare well with those of selenoanisoles and other phenyl alkyl selenides. The chemical shifts are also compared with the corresponding values in other heterocycles containing a selenophene moiety. 相似文献
60.
Andr Laurent Alain Marsura Et Jean-Louis Pierre 《Journal of heterocyclic chemistry》1980,17(5):1009-1017
A facile synthesis of aziridine is describe. It is the reaction between Grignard regents and α-hydroxoximes in toluene. The aziridine alchohols are cyclised into 2-oxo-oxathiazolidines. The use of the nuclear Overhauser effect allows the assignment of the relative configurations of these latter compounds and also the configuration of the aziridine alcohols. A proof of the Grignard reagent complex with the alcoolate id given by action of methylmagensium bromide with 2-phenyl 3-methanol azirine. The asymetrie insuction observed is discussed with a transition state involving this complex. 相似文献