Copper-Catalyzed Enantioselective Synthesis of α-Hydroxyamine Using Monodentate Phosphoramidites

Development of new methods for the introduction of a nitrogen atom to a carbonyl group is still the most important synthetic target. Cu-catalyzed addition of organozinc reagents to α,β-unsaturated carbonyl compounds has been the subject of intensive investigation.[1] Moreover, trapping of the intermediate Zn-enolates has been achieved using nitrosobenzene. To demonstrate the feasibility of developing enantioselective variants of these tandem C-C bond formations,α,β-unsaturated substrates a～d was subjected to standard reaction conditions using Feringa's (L1*, L2*) and our own phosphoramidite ligands (L3*, L4*). In this reaction, medium to high levels of enantioselectivities were observed.     

Study on the Interaction of Colloidal Gold with Taq DNA Polymerase

The interaction of colloidal gold with Taq DNA polymerase （Taq） was investigated in this study. Taq-gold conjugate was formed by adding the enzyme to the colloidal gold solution, as evidenced by UV-Vis spectroscopy, X-ray photoelectron spectroscopy, and photon cross correlation spectroscopy measurements. The conjugate was further characterized by transmission electron microscopy. It was found that the Taq-gold conjugate particles were still spherical and well-dispersed. The influence of gold nanoparticles on the bioactivity of Taq was studied by analyzing the yield of the polymerase chain reaction amplification. Results indicated that the enzymatic activity of Taq decreased after interaction with the colloidal gold.     

NEW HETEROCYCLIC SYSTEM SYNTHESIS I REACTION OF DIHYDRO-1,5-BENZO-DIAZEPINES AND THIAZEPINES WITH (ETHOXYCARBONYL)CARBENES

Dihydro-1-benzoyl-1,5-benzodiazepines react with (ethoxycarbonyl)carbenes to give 4H-azirino-[1,2-a][1,5]-benzodiazepines and unexpected new tin9 system 1H-pyrrolo-[1,2-a][1,5]-benzodiazepines. Dihydro-1,5-benzothiazepines react with (ethoxycarbonyl)carbenes in cyclohexane to gire unexpected rin9 cleavage products ethyl (2E, 4E)-3-aryl-2-arylthiohexadienoates.     

掺杂对铒、钕蒽基配合物的光二聚反应及光磁性能调控的影响

选择具有光化学活性的蒽甲基膦酸二乙酯(depma)为配体、部分镧系离子为金属中心构筑了3例同构的单核配合物Ln (SCN)₂(NO₃)(depma)₂(4-hpy)₂(Ln=Er (1Er),Nd (2Nd),Y (3Y)),对其单分子磁体行为、发光性质和光二聚行为等进行了研究。荧光测试显示1Er和2Nd因配体到稀土离子的能量转移而显示近红外发光,但在可见光区无明显发光行为,同时不能发生光二聚反应。而3Y可以发射黄绿色荧光,并发生光二聚反应生成[Y (SCN)₂(NO₃)(depma₂)(4-hpy)₂]_n(3Y-UV)。磁性测试显示1Er和2Nd在低温下均表现出场诱导的慢磁弛豫性质,其中2Nd的弛豫过程主要由拉曼过程主导。通过将Er^Ⅲ或Nd^Ⅲ掺杂到3Y晶格中,得到同构配合物Ln_0.1Y_0.9(SCN)₂(NO₃)(depma)₂(4-hpy)₂(Ln=Er (1Er@Y),Nd (2Nd@Y)),测试结果表明掺杂样品可以发生部分光二聚行为,同时伴随发光颜色的变化。此外,化合物2Nd@Y光反应前后磁性也发生了变化,拉曼过程的指数从3.8(2Nd@Y)提升到5.2(2Nd@Y-UV),对应于光照前后晶格声子结构的变化。     

用分子动力学模拟天然气水合物的抑制效应

用分子动力学模拟方法确定了结构H型(SH)天然气水合物的稳定晶体生长面为(001), 系统研究了277 K时三种动力学抑制剂对此晶面的影响. 模拟显示抑制剂中的氧与表面水分子形成氢键, 从而破坏原有的稳定结构, 造成水合物笼型结构坍塌, 达到抑制水合物形成的效果. 比较三种不同动力学抑制剂对SH的抑制效果得出: PVCap＞PEO＞PVP. 在此基础上研究了PVCap对天然气水合物结构I型(SI), 结构II型(SII)和SH三种不同晶型的抑制效应. 模拟发现抑制效果的次序为: SH＞SI＞SII.     

基于数字图像相关技术的岩样破坏实验的应用研究

为了解喀喇昆仑公路(中国段)沿线岩石裂纹演化及受力后的力学性能(位移和应变),采用数字图像相关技术,对三点弯曲加载条件下的灰白石英粉砂岩和片麻岩试件在万能试验机上进行了破坏实验,得到了外力作用下裂纹生成、扩展等演化过程及两种岩样在加载直至破坏过程中的位移场和平均应变曲线.实验结果表明,在相同条件下,灰白石英粉砂岩比片麻...     

红外混合光学系统衍射效率的测量方法及其实现

简要介绍了二元光学器件衍射效率的理论计算方法,给出了一些衍射效率的测量方法,在此基础上设计了一套实用的衍射效率测试系统,并针对一个应用在3~5μm波段的具体红外混合光学系统进行了测试,给出了测试结果,此测试系统对红外混合光学系统的设计加工具有实际意义。     

Mean Field Theory of Ising Model on Sierpinski

We study Ising model on Sierpinski carpets by using mean field theory. We find a phase transition at T_c > 0 which is dependent on the geometrical factors. The critical exponents are calculated and found to be the same as the values for translationally invariant lattices.     

Statistical Distribution of q-Bosonic Oscillators

The statistical distribution for a system of q-deformed harmonic oscillators is studied and an explicit form of q-dependence of the distribution function is given. The physical meaning of the deformation parameter q is discussed.     

腰接基对对苯二甲酸-双(4-甲氧基苯酯)液晶性的 影响

合成了一系列不同腰接取代基的刚性对苯二甲酸-双(4-甲氧基苯酯)小分子液晶化合物,研究了不同腰接取代基液晶性的影响。研究发现,如果在对苯二甲酸-双(4-甲氧基苯酯)的腰部引入不同结构的取代基,将不同程度地降低其熔点和液晶清亮点,合适的取代基则有利于液晶相的生成。