Application of Nanogold Probe Coupled with Silver Enhancement in Rapid cTnI Colorimetric Immunoassay

Cardiac troponin I (cTnI) in the serum of patients has been established as a principal biochemical marker of myocardial damage1-4. Fast detection of cTnI will be helpful for the diagnosis of acute myocardial infarction (AMI), the identification of myocardial injury (MI) and the stratification of cardiac risk. A number of serological tests have been developed for the detection of cTnI. As known, among many methods, enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA) wer…     

Study on the Radius of an Electrical Spherical Micelle： Functional Theoretical Approach

For the purpose of eliminating restriction, the Poisson-Bokzmann (PB) equation, which represents the potential of the electrical double layer of spherical miceUes, can be solved analytically only under the lower potential condition, a kind of iterative method in functional analysis theory has been used. The radius of the spherical particle can be obtained from the diagram of the second iterative solution of the potential versus the distance from the center of the particle. The influences of the concentration of the ions, the charge number of ions, the aggregation number of the particle, the dielectric constant of solvent and the temperature of system on the radius also have been studied.     

胆红素与胆汁酸盐作用时的构象变化

利用PPP-SCF-CI-DV量子化学程序拟合胆红素以及胆汁酸盐-胆红素水溶液的UV和CD谱, 借以研究胆红素及其与胆汁酸盐复合物的构象性质。发现胆红素与胆汁酸盐作用时, 两个双吡咯生色团的扭角由104°变成112°, 仍保持形成分子内氢键的状态, 其UV及CD谱两个吸收峰间隔的增宽, 主要是胆红素的一侧双吡咯生色团与胆汁酸盐呈疏水性结合的原故; 二羟基和三羟基胆汁酸盐所形成的二元复合物园二色谱的差别, 是胆红素的对映选择性结合造成的。     

E-和Z-α-取代肉桂酰哌嗪类的合成及其光异构化反应

Z-肉桂酰哌嗪类化合物具有保护大脑、恢复脑损伤后机能和促进记忆、学习的活性,而E型物具有抗心绞痛活性。显然,这类化     

Synthesis of a Dopamimetic Thionated Dipeptide Prodrug of L-DOPA

L-DOPA has gained widespread credit over the past decades as being the mainstay of the pharmacological treatment of Parkinson‘s disease. However, there are many adverse effects associated with the use of L-DOPA. The prodrug approach is the most promising way to solve the problem. In this article, a thionated dipeptide prodrug of L-DOPA 11 was synthesized via 10 steps in a total yield of 26.5% from L-DOPA.     

An Efficient Synthesis of Cyclopeptides Bridged with Aliphatic-aryl Ether Bond

Based on the pseudo-dilution effect (PDE) on solid support, three cyclopeptides with an aliphatic-aryl ether bond as the bridge were synthesized via SN2 reaction between bromoacetylated at N-terminal and the phenol -OH group in C-terminal Tyr residue. All the products were obtained in good overall yields and characterized by related analytic data.     

Total Synthesis of (±)-Butyl Ester of Rosmarinic Acid

Rosmarinic acid, a well-known natural product firstly isolated from rosemary by Scarpati and Oriente in 19581, possesses various kinds of biological activities such as antioxidant2 and antibacterial3. Recently, the synthesis and biological activities of related compounds of rosmarinic acid have received much attention, such as 4, 4?′-O-di-β-D- glucopyranosyl rosmarinic acid4, methyl ester of rosmarinic acid5-6 and rabdosiin7. Butyl ester of rosmarinic acid 1 (Scheme 1) was isolated from Is…     

A New Flavanone from the Bark of Morus macoura Miq.

“Sang Bai Pi”, the bark of mulberry, has been used as herbal medicine to treat diabetes, arthritis, rheumatism for thousands of years. Phytochemical studies on some Morus species revealed that they contained phenolic compounds1. Macrourone C (1) was isolated from Morus macroura Miq. In this paper, the structure of 1 was elucidated on the basis of spectoscopic evidence.Figure 1 Structure and Key HMBC for 1 1Macrourone C (1), a yellow powder, exhibited dark blue fluorescence under UV li…     

A Taxatetraene from Microbial Transformation of Sinenxan A

Sinenxan A [2α, 5α, 10β, 14β-tetraacetoxytaxa-4(20), ll-diene, 1] was biotransformed by a filamentous fungus, Aspergillus niger JCM 5546, and an unusual taxatetraene [2α,5α-acetoxytaxa-4(20), 10(11), 12(18), 13(14)-tetraene, 2], together with two known products,10β-deacetyl sinenxan A (3) and 10β, 14β-dideacetyl sinenxan A (4) were produced.     

Synthesis of novel 15-membered macrolide dimers

A series of novel dimers of 15-membered macrolides was synthesized and evaluated.The dimers exhibited excellent activity against erythromycin-susceptible S.pneumonia,but did not show any improved activity against erythromycin-resistant S. pneumoniae encoded by erm gene.