全文获取类型
收费全文 | 1105篇 |
免费 | 25篇 |
国内免费 | 2篇 |
专业分类
化学 | 841篇 |
晶体学 | 22篇 |
力学 | 4篇 |
数学 | 64篇 |
物理学 | 201篇 |
出版年
2022年 | 15篇 |
2021年 | 23篇 |
2020年 | 9篇 |
2019年 | 19篇 |
2018年 | 16篇 |
2017年 | 11篇 |
2016年 | 11篇 |
2015年 | 20篇 |
2014年 | 32篇 |
2013年 | 51篇 |
2012年 | 71篇 |
2011年 | 83篇 |
2010年 | 43篇 |
2009年 | 39篇 |
2008年 | 61篇 |
2007年 | 74篇 |
2006年 | 60篇 |
2005年 | 70篇 |
2004年 | 70篇 |
2003年 | 69篇 |
2002年 | 56篇 |
2001年 | 10篇 |
2000年 | 11篇 |
1999年 | 9篇 |
1998年 | 8篇 |
1997年 | 15篇 |
1996年 | 10篇 |
1995年 | 9篇 |
1994年 | 9篇 |
1993年 | 6篇 |
1992年 | 10篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 10篇 |
1986年 | 3篇 |
1985年 | 17篇 |
1984年 | 12篇 |
1983年 | 7篇 |
1982年 | 8篇 |
1981年 | 6篇 |
1980年 | 12篇 |
1979年 | 10篇 |
1978年 | 9篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1972年 | 2篇 |
1969年 | 2篇 |
1959年 | 2篇 |
排序方式: 共有1132条查询结果,搜索用时 0 毫秒
61.
Hideo Hirai Kozo Sawada Matsuhiko Aratani Masashi Hashimoto 《Tetrahedron letters》1985,26(14):1739-1742
A stereoselective kinetic protonation of the azetidinone enolate was studied and an efficient synthesis of(cis) was achieved via aldol reaction of with acetone followed by the kinetic protonation with Ph3SnH as proton source. 相似文献
62.
[reaction: see text] The enantioselective total synthesis of (+)-allocyathin B(2) has been achieved. Our approach features a convergent enantioselective construction of the 5-6-7 tricyclic core system using the originally developed chiral building blocks via asymmetric catalysis, the intramolecular aldol reaction in high yield, successful samarium diiodide-mediated ring expansion, and a newly developed double-bond installation method. 相似文献
63.
Umetsu K Tanaka M Yuasa I Adachi N Miyoshi A Kashimura S Park KS Wei YH Watanabe G Osawa M 《Electrophoresis》2005,26(1):91-98
We present a reliable, rapid, and economical multiplex amplified product-length polymorphism (APLP) method for analyzing the haplogroup-diagnostic mitochondrial single-nucleotide polymorphisms (mtSNPs) in East Asian populations. By examining only 36 haplogroup-specific mtSNPs in the coding region by using four 9-multiplex polymerase chain reaction (PCR) and subsequent electrophoresis, we could safely assign 1815 individuals from 8 populations of Japanese, Korean, Chinese, and Germans to 45 relevant haplogroups. This multiplex APLP analysis of coding-region mtSNPs for haplogrouping is especially useful not only for molecular phylogenetic studies but also for large-scale association studies due to its rapid and economical nature. This is the first panel of mtSNPs in the coding region to be used for haplogrouping of East Asian populations. 相似文献
64.
Shuichi Nakamura Masashi Hayashi Yasutoshi Kamada Ryosuke Sasaki Yuichi Hiramatsu Norio Shibata Takeshi Toru 《Tetrahedron letters》2010,51(29):3820-3823
A catalytic enantioselective desymmetrization of meso-N-(heteroarenesulfonyl)aziridines with TMSN3 using chiral Lewis acids afforded products with high enantioselectivity. As proof of the utility of this procedure, the precursor of selective κ-opioid agonist (1S,2S)-(−)-U-50,488 was synthesized. 相似文献
65.
Nakamura K Takashima T Shirahata T Hino S Hasegawa M Mazaki Y Misaki Y 《Organic letters》2011,13(12):3122-3125
New dimeric and trimeric TTF derivatives with methylenedithio spacers (1a,b, 2a, and 2b) have been synthesized. X-ray structure analysis revealed that TTF units of the dimer 1b adopted distorted face-to-face overlapping arrangement both in intra- and intermolecular stacking. Cyclic voltammetric study indicated that trimeric 2a was in favor of taking di- and tetracationic states, while the dimeric 1a was in favor of taking a monocation. The absorption spectroscopic study suggested an existence of the strong face-to-face interaction particularly in di-, tri-, and tetracationic state of the trimeric TTF derivatives. 相似文献
66.
Masashi Daido Akihito Koizumi Motoyuki Shiga Masanori Tachikawa 《Theoretical chemistry accounts》2011,130(2-3):385-391
The structure of Watson?CCrick type guanine?Ccytosine (G?CC) base pair has been studied by classical hybrid Monte Carlo (HMC) and quantum path integral hybrid Monte Carlo (PIHMC) simulations on the semiempirical PM6 potential energy surface. For the three NH?X hydrogen-bonded moieties, the intramolecular NH bonds are found systematically longer while the H?X distance shorter in the PIHMC simulation than in the HMC simulation. We found that the hydrogen bonded length N?X correlates with the H?X distance, but not with the NH distance. A correlation is also between the neighboring hydrogen bonds in the G?CC base pair. 相似文献
67.
Koji YamamotoHiroki Sugiura Ryo AmemiyaHaruo Aikawa Zengjian AnMasahiko Yamaguchi Masashi Mizukami Kazue Kurihara 《Tetrahedron》2011,67(33):5972-5978
Optically active ethynylhelicene pentamers and hexamers linked by disulfide bonds were synthesized. They formed self-assembled monolayers (SAMs) with double helix structure on gold surfaces, which were analyzed by infrared reflection-absorption spectroscopy (IR-RAS), quartz crystal microbalance (QCM), surface plasmon resonance (SPR), and circular dichroism (CD). Double helix SAMs could be formed on gold surfaces either from double helices or random coils in solution. The double helices on the surface were more stable than in solution. This result suggested the presence of strong intercomplex interactions between double helix complexes on the surface. 相似文献
68.
Tsuda M Izui N Shimbo K Sato M Fukushi E Kawabata J Katsumata K Horiguchi T Kobayashi J 《The Journal of organic chemistry》2003,68(13):5339-5345
A novel cytotoxic 16-membered macrodiolide, amphidinolide X (1), has been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-42). The gross structure of 1 was elucidated on the basis of spectroscopic data including one-bond and long-range (13)C-(13)C correlations. The relative and absolute stereochemistries were determined by combined analyses of NOESY data and (1)H-(1)H and (1)H-(13)C coupling constants of 1 and NMR data of the degradation products. Amphidinolide X (1) is the first macrodiolide consisting of polyketide-derived diacid and diol units from natural sources. The biosynthetic origins of 1 were investigated by means of feeding experiments with (13)C-labeled acetates. 相似文献
69.
Itoh T Nagata K Yokoya M Miyazaki M Kameoka K Nakamura S Ohsawa A 《Chemical & pharmaceutical bulletin》2003,51(8):951-955
Chiral 1-substituted isoquinoline derivatives, which were obtained by the reaction using alanine derivatives as chiral auxiliaries, were transformed to (S)-2,3,9,10,11-pentamethoxyhomoprotoberberine (7) and a synthetic intermediate for O-methylkreysigine (9) in good yields and high stereoselectivity. The corresponding chiral allyl derivative of isoquinoline was transformed to a pyrrolidinoisoquinoline (16) in a highly enantioselective manner. 相似文献
70.
Pinacol-type coupling reaction products presenting a high meso-diastereoselectivity (the ratio dl/meso was 4/96 up to 1/99) were obtained in fair to good yields (24–69%) using several aromatic aldehydes as starting materials and aluminium powder/copper sulfate as catalysts, in water, under reflux conditions. 相似文献