Development of a novel compression tester and rheo-mechanical properties of wet-mass powder. I--Effect of kneading time on the rheo-mechanical properties

In our previous paper [Watano S., et al., Chem. Phram. Bull., 49(1), 64-68, (2001)], a compaction tester was developed to quantitatively evaluate the water dispersion condition of wet kneaded masses prepared by a paddle type kneader. It was also demonstrated that the physical properties of pellets prepared by extrusion granulation after the kneading could be well predicted by the vertical pressure transmission obtained through the compaction tester. However, in this compression tester, the vertical pressure transmission was just obtained and rheological and mechanical properties (so called rheo-mechanical properties) of wet mass-powder that should be the most important to determine the deformation process were not well studied. In this study, a novel compression tester, which can measure both vertical and radial pressure transmissions, has been developed. Based on the compression test, mechanical property (Young's modulus) and rheological property (effective internal friction) of wet mass powder prepared by different kneading times were quantitatively investigated. Granules (pellets) were then obtained through the extrusion granulation and fluidized bed drying, and the physical properties (strength and disintegration time) of the obtained pellet were evaluated. The relationship between the granule (pellet) physical properties and the mechanical and rheological (rheo-mechanical) properties was analyzed.     

Synthetic study of 1-substituted carbapenem antibiotics

Total synthesis of 1-substituted carbapenems is described. The key step is the reaction of acetoxyazetidinone ($\text{7}$) with ketene silyl acetal ($\text{8}$).     

THE BLUE LIGHT RESPONSE OF STOMATA: PULSE KINETICS AND SOME MECHANISTIC IMPLICATIONS*

Abstract— Intact leaves of Commelina communis irradiated with high fluence rates of red light, showed discrete increases in stomatal conductance in response to pulses (1-100 s) of blue light (250 μmol m^?2 s^?1). Red light pulses were ineffective, indicating that the conductance increases were not mediated by photosynthesis and that they constitute a specific stomatal response to blue light. The response peaked 15 min after the pulse and was completed within50–60 min. Conductance increases were proportional to pulse duration up to about 30 s and saturated at longer exposures. The relationship between stomatal responses and pulse duration approximately fitted an exponential function, with a t 9s. Pulse responses at two different fluences indicated that reciprocity held. Responses to two consecutive pulses varied with time between pulses. A saturating pulse applied immediately after a preceding one induced no additional response; two saturating pulses 50 min apart caused two identical, consecutive responses. Total increases in conductance induced by two pulses separated by intermediate time intervals increased with time between pulses with a = 9 min. These results point to a blue light-dependent photoconversion of a molecular form, with the activity of the photoconversion product decaying in a thermal reaction. Under continuous blue light, prevailing fluence rates and rates of the light and thermal reactions are postulated to determine steady-state activities of the photoconversion product and proportional increases in conductance levels. These findings have implications for the environmental and metabolic roles of the stomatal response to blue light.     

Surface treatment of borosilicate glass beakers for prevention of sodium contamination

Pyrex glass beakers are treated with molten Ca(NO₃)₂-KNO₃ (20:80 mol %) mixture at 500°C for 3 h. Treated beakers can be used successfully in wet oxidation of SRM-1571 Orchard Leaves for sodium determination; at least 10 oxidations can be done without sodium contamination. Mass spectrometry is used to investigate the depth profiles of glass components within 60 nm of the glass surfaces and to clarify the mechanism of the sodium contamination.     

Remarkable stereocontrol observed in the ring formation by intramolecular hosomi-sakurai reaction

The cyclization of 2-(3′,4′-dimethyl6?′-trimethylsilyl-4′-hexenyl)-2-cyclohexenone with TiCl₄, afforded stereospecifically 6α,7α-dimethyl-6β-vinyl-5βH-1-decalone derivative and the two-fold diastereoselection involved is reasoned in terms of orientation control and folding strain control.     

Variation of lattice dimensions in epitaxial SnS films on MgO(001)

Epitaxial and polycrystalline SnS films were prepared on MgO(001) and glass substrates using molecular beam epitaxy. The films were characterized by X-ray diffraction method. The orientations of epitaxial films were (010)[100]SnS||(001)[100]MgO or (010)[001]SnS||(001)[100]MgO. Lattice parameters of the polycrystalline film closely resembled those of bulk SnS at room temperature. However, the lattice parameters of epitaxial films varied widely and were very different from those of bulk SnS at room temperature. Considering the lattice dimensions and a/c ratio, the films roughly correspond to bulk SnS at elevated temperatures from 371 to 666 K. SEM images of the films showed needle- or circular-like SnS crystallites segregated from the epitaxial films. Respective energies of indirect band gaps of the films and refractive index of the polycrystalline film were estimated using results of optical transmission experiments.     

Ultra-High Resolution Optical Coherence Tomography (OCT) Using a Halogen Lamp as the Light Source

The axial resolution of optical coherence tomography (OCT) is determined by the coherence length of the light source. We demonstrate for the first time high-resolution OCT of biological tissue using a halogen lamp as the light source for a low coherence interferometer. High-resolution OCT imaging with 3.5 μm resolution was performed successfully for onion and porcine skin, although the coherence light power for illumination of a sample is as small as 100 nW.     

Simultaneous Measurement of Refractive Index and Thickness of Transparent Plates by Low Coherence Interferometry

We demonstrate a novel low coherence Michelson interferometer which can provide simultaneous measurement of the refractive index and thickness of transparent plates used as a measured object. Unlike the existing low coherence interferometers reported so far, either an object or a focusing lens aligned on the signal arm is scanned repeatedly by a precise translation stage in synchronization with movement of a reflection mirror on the reference arm. The so-called object or lens scanning method gives us two measured quantities a movement distance of the stage between two light focusing states on the front and rear planes of an object and the corresponding optical path difference. These two measured quantities, result in desirable values of the index and thickness of the object with a short calculation. The measurement accuracy of ≤0.1% is expected for a thickness of more than 1 mm. In the experiment using the object scanning method, the accuracy of 0.3% or less was successfully attained for nearly 1-mm thick plates of fused quartz, sapphire, LiTaO₃ and slide glass.     

Mean-risk analysis of risk aversion and wealth effects on optimal portfolios with multiple investment opportunities

In this paper, we first define risk in an axiomatic way and a class of utility functions suitable for the so-called mean-risk analysis. Then, we show that, in a portfolio selection problem with multiple risky investments, an investor who is more risk averse in the Arrow-Pratt sense prefers less risk, in the sense of this paper, with less mean return, and an investor who displays increasing (decreasing) relative risk aversion becomes more conservative (aggressive) as the initial capital increases. The risk aversion effect for diversification on optimal portfolios is also discussed.