Process-Dependent Solute Transport in Porous Media

Transport in Porous Media - Solute transport under single-phase flow conditions in porous micromodels was studied using high-resolution optical imaging. Experiments examined loading (injection of...     

Detecting cavitation in globe valves by two methods: Characteristic diagrams and acoustic analysis

Cavitation is a dynamic phenomenon that occurs in fluid flows when the local pressure is lower than the saturated vapor pressure at ambient temperature. The formation and collapse of cavitation bubbles leads to corrosion and pitting of metal surfaces. Considering the fact that damage to moving parts caused by cavitation has serious consequences it is important to be able to detect it. In this research an attempt is made to study the development of cavitation in globe valves using two different methods: characteristic diagrams and acoustic measurement. The results of the two methods are found to be in general agreement within acceptable levels of accuracy.     

A lifetime model with increasing failure rate

This paper deals with a new two-parameter lifetime distribution with increasing failure rate. This distribution is constructed as a distribution of a random sum of independent exponential random variables when the sample size has a zero truncated binomial distribution. Various statistical properties of the distribution are derived. We estimate the parameters by maximum likelihood and obtain the Fisher information matrix. Simulation studies show the performance of the estimators. Also, estimation of the parameters is considered in the presence of censoring. A real data set is analyzed for illustrative purposes and it is noted that the distribution is a good competitor to the gamma, Weibull, exponentiated exponential, weighted exponential and Poisson-exponential distributions for this data set.     

99mTc-labeling of a dithiocarbamate-DWAY fragment using [99mTcN]2+ core for the preparation of potential 5HT1A receptor imaging agents

1-(2-methoxy phenyl) piperazine fragment of WAY100635 or its phenolic analogue, derived from DWAY is used to design the desired structure of 5HT_1A receptor imaging agents. In this study a DWAY analogue was labeled with ^99mTc-nitrido ([^99mTcN]²⁺) core via dithiocarbamate. 2-(piperazin-1-yl) phenol dithiocarbamate was synthesized by the reaction of 2-(piperazin-1-yl) phenol with an equivalent amount of carbon disulfide in KOH solution then radiolabeled with ^99mTc-nitrido core. The final complex was characterized by HPLC and its radiochemical purity was more than 90 %. In vitro stability studies have shown the complex was stable at least 4 h after labeling at room temperature. The n-octanol/water partition coefficient experiment demonstrated log p = 1.34 for ^99mTcN–OHPP–DTC. Biodistribution results showed that radio tracer had moderate brain uptake (0.39 ± 0.03 %ID/g at 15 min and 0.29 ± 0.02 %ID/g at 120 min) and good retention, suggesting that this complex may lead to a further development of a radiotracer with specific binding to 5-HT_1A receptor.