Quantitative characterization of critical nanoclusters nucleated on large single molecules

First order phase transitions involve nucleation, formation of nanoscale regions of a new phase within a metastable parent phase. Using the heterogeneous nucleation theorem we show how clusters formed by nucleation on single molecules evolve from the gas phase and determine the critical size beyond which condensation starts to form aerosol particles. Our experiments reveal the activation of molecules into droplets to happen via formation of critical clusters substantially larger than the seed molecule. The nanosized critical clusters were found to be well predicted by the Kelvin-Thomson relation pointing directly to the key step in the phase transition.     

Medial tibial pain: a dynamic contrast-enhanced MRI study.

The purpose of this study was to compare the sensitivity of different magnetic resonance imaging (MRI) sequences to depict periosteal edema in patients with medial tibial pain. Additionally, we evaluated the ability of dynamic contrast-enhanced imaging (DCES) to depict possible temporal alterations in muscular perfusion within compartments of the leg. Fifteen patients with medial tibial pain were examined with MRI. T1-, T2-weighted, proton density axial images and dynamic and static phase post-contrast images were compared in ability to depict periosteal edema. STIR was used in seven cases to depict bone marrow edema. Images were analyzed to detect signs of compartment edema. Region-of-interest measurements in compartments were performed during DCES and compared with controls. In detecting periosteal edema, post-contrast T1-weighted images were better than spin echo T2-weighted and proton density images or STIR images, but STIR depicted the bone marrow edema best. DCES best demonstrated the gradually enhancing periostitis. Four subjects with severe periosteal edema had visually detectable pathologic enhancement during DCES in the deep posterior compartment of the leg. Percentage enhancement in the deep posterior compartment of the leg was greater in patients than in controls. The fast enhancement phase in the deep posterior compartment began slightly slower in patients than in controls, but it continued longer. We believe that periosteal edema in bone stress reaction can cause impairment of venous flow in the deep posterior compartment. MRI can depict both these conditions. In patients with medial tibial pain, MR imaging protocol should include axial STIR images (to depict bone pathology) with T1-weighted axial pre and post-contrast images, and dynamic contrast enhanced imaging to show periosteal edema and abnormal contrast enhancement within a compartment.     

BRST Quantization of Unimodular Gravity

We study the quantization of two versions of unimodular gravity, namely fully diffeomorphism-invariant unimodular gravity and unimodular gravity with fixed metric determinant, utilizing standard path integral approach. We derive the BRST symmetry of effective actions corresponding to several relevant gauge conditions. We observe that for some gauge conditions, the restricted gauge structure may complicate the formulation and effective actions, in particular, if the chosen gauge conditions involve the canonical momentum conjugate to the induced metric on the spatial hypersurface. The BRST symmetry is extended further to the finite field-dependent BRST transformation, in order to establish the mapping between different gauge conditions in each of the two versions of unimodular gravity.     

Quantitative liver iron measurement by magnetic resonance imaging: in vitro and in vivo assessment of the liver to muscle signal intensity and the R2* methods

Purpose

To evaluate the liver-to-muscle signal intensity and R2* methods to gain a transferable, clinical application for liver iron measurement.

Materials and Methods

Sixteen liver phantoms and 33 human subjects were examined using three 1.5-T MRI scanners from two different vendors. Phantom-to-muscle and liver-to-muscle signal intensity ratios were analyzed to determine MRI estimated phantom and hepatic iron concentration (M-PIC and M-HIC, respectively). R2* was calculated for the phantoms and the liver of human subjects. Seven patients' biochemical hepatic iron concentration was obtained.

Results

M-PIC and R2* results of three scanners correlated linearly to phantom iron concentrations (r=0.984 to 0.989 and r=0.972 to 0.981, respectively), and no significant difference between the scanners was found (P=.482 and P=.846, respectively) in vitro. The patients' R2* correlated linearly to M-HIC of the standard scanner (r=0.981). M-HIC values did not differ from those obtained from the biopsy specimens (P=.230). The difference in M-HIC was significant, but the difference in R2* was not significant between the scanners (P<.0001 and P=.505, respectively) in vivo.

Conclusion

Both methods, M-HIC and R2*, are reliable iron concentration indicators with linear dependence on iron concentration in vivo and in vitro. The R2* method was found to be comparable among different scanners. Transferability testing is needed for the use of the methods at various scanners.     

Second-order stochastic dominance constrained portfolio optimization: Theory and computational tests

Due to the definition of second-order stochastic dominance (SSD) in terms of utility theory, portfolio optimization with SSD constraints is of major practical interest. We contribute to the field in two ways: first, we present a self-contained theory with some new results and new proofs of known results; second, we perform a set of tests for computational efficiency. We provide new and simple arguments for the formulation of SSD constraints in a mathematical programming framework. For many individuals, an SSD constraint may seem too severe wherefore various relaxations (ASSD), have been proposed. We introduce yet another relaxation, directional SSD, where a candidate portfolio is admissible if a step from the benchmark in the direction of the candidate yields a dominating portfolio. Optimal step size depends on individual preferences reflected by the objective function. We compare computational efficiency of seven approaches for SD constrained portfolio problems, including SSD and ASSD constrained cases.     

Spectrally optimal illuminations for diabetic retinopathy detection in retinal imaging

Optical Review - Retinal photography is a standard method for recording retinal diseases for subsequent analysis and diagnosis. However, the currently used white light or red-free retinal imaging...     

Analysis of nitromethane from samples exposed in vitro to chloropicrin by stable isotope dilution headspace gas chromatography with mass spectrometry

Chloropicrin (trichloronitromethane) is a widely used soil fumigant and an old chemical warfare agent. The metabolism of chloropicrin is not well known in mammals but nitromethane has been shown to be one of its main metabolites. Here, a fast and simple headspace gas chromatography with mass spectrometry method was applied for the measurement of nitromethane from aqueous samples. The analytical method was validated using stable isotope labeled internal standard and a small sample volume of 260 μL. No conventional sample preparation steps were needed. The method was accurate (relative standard deviations ≤1.5%) and linear (R² = 0.9996) within the concentration range of 0.1?6.0 μg/mL. This method was used to measure nitromethane in in vitro incubations with human and pig liver cell fractions containing enzymes for xenobiotic metabolism, exposed to chloropicrin. The results indicate that the presence of glutathione is necessary for the formation of nitromethane from chloropicrin. Also, nitromethane was formed mostly in liver cytosol fractions, but not in microsomal fractions after the incubation with chloropicrin. Our results suggest that although nitromethane is not the unequivocal biomarker of chloropicrin exposure, this method could be applied for screening the elevated levels in humans after chloropicrin exposure.     

Preoperative tissue characterization with chemical shift imaging: a case report of an epidermal cyst.

We introduce here a case of an epidermal cyst, which was preoperatively examined with chemical shift MR imaging at 0.1-T magnetic field. The case shows that fat/water separation method can be successfully used in tissue characterization.     

Medium-spin levels in the N=83 nucleus147Gd

Zeitschrift für Physik A Hadrons and nuclei - Levels of theN=83 nucleus147Gd have been investigated by methods of in-beamγ-ray and conversion electron spectroscopy using the147Sm(3He, 3n)...