Reactivity of Hydroxy and Amino Derivatives of 2‐Phenyl‐1H‐imidazoline and 2‐Phenyl‐1H‐imidazole toward Isocyanates: Synthesis of Appropriate Carbamates and Ureas

Reactivity of 2‐(4‐hydroxyphenyl)‐1H‐imidazoline and 2‐(4‐hydroxyphenyl)‐1H‐imidazole toward substituted phenyl isocyanates was studied. When mentioned imidazoline was treated with 2.5 equiv of substituted phenyl isocyanate, three N,O‐dicarboxamides were prepared (substituents are H, 4‐NO₂, and 4‐CH₃). Subsequently, N,O‐diacetylated 2‐(4‐hydroxyphenyl)‐1H‐imidazoline was prepared and selective deprotection method was developed for preparation of 1‐acetyl‐2‐(4‐hydroxyphenyl)‐1H‐imidazoline using diethylamine in acetone. Six carbamates derived from this imidazoline were then prepared using 1.1 equiv of substituted phenyl isocyanates (substituents are H, 4‐CH₃, 4‐OCH₃, 4‐NO₂, 4‐CN, and 3‐CF₃). Finally, two carbamates were prepared from 2‐(4‐hydroxyphenyl)‐1H‐imidazole (substituents are 4‐NO₂ and 4‐CN). No reactivity to imidazole ring was observed in this case. Eight derivatives were subjected to antimycobacterial screening. Concurrently, reactivity of 2‐(2‐aminophenyl)‐ and 2‐(2‐hydroxyphenyl)‐1H‐imidazole toward aliphatic and aromatic isocyanates was studied. Eight ureas were prepared using equivalent mixture of 2‐(2‐aminophenyl)‐1H‐imidazole and isocyanate (Et, Pr, isoPr, terc‐Bu, Cy, Ph, 4‐CH₃C₆H₄, 4‐CNC₆H₄). Similar attempts to obtain related carbamates from 2‐(2‐hydroxyphenyl)‐1H‐imidazole lead only to three substituted phenyl carbamates (substituents are 4‐CH₃, 4‐NO₂, and 4‐CN). In both cases, no reactivity to imidazole ring was observed again.     

Magnetic particles–based biosensor for biogenic amines using an optical oxygen sensor as a transducer

We have developed a fibre optic biosensor with incorporated magnetic microparticles for the determination of biogenic amines. The enzyme diamine oxidase from Pisum sativum was immobilized either on chitosan-coated magnetic microparticles or on commercial microbeads modified with a ferrofluid. Both the immobilized enzyme and the ruthenium complex were incorporated into a UV-cured inorganic–organic polymer composite and deposited on a lens that was connected, by optical fibres, to an electro-optical detector. The enzyme catalyzes the oxidation of amines under consumption of oxygen. The latter was determined by measuring the quenched fluorescence lifetime of the ruthenium complex. The limits of detection for the biogenic amines putrescine and cadaverine are 25–30 μmol?L^?1, and responses are linear up to a concentration of 1 mmol L^?1.

The motion characteristics of the double‐pendulum system with skew walls

Many components of machines and other technological devices (chains and bodies hanging on the ropes) can be modeled as multiple pendulums situated in tubes or holes of limited space. The investigation of motion of such systems represents the substance of many real technological problems; therefore, it stirred up motivation to perform research on vibration of a double pendulum situated between two skew rigid walls. The analyzed system was set into motion by the horizontal movement of its suspending. The results of the simulations show that the system can exhibit both the regular and chaotic movements depending on the excitation frequency. The development of the computational model, which is applicable for more complex investigations, and learning more on the motion character of a double pendulum, the movement of which is limited by skew walls, are the principal contributions of the presented article.     

Einen Quecksilberverschluss

Ohne Zusammenfassung     

Quantum effects of periodic orbits for the kicked top

We analyze traces of powers of the time evolution operator of a periodically kicked top. Semiclassically, such traces are related to periodic orbits of the classical map. We derive the semiclassical traces in a coherent state basis and show how the periodic orbits can be recovered via a Fourier transform. A breakdown of the stationary phase approximation is detected. The quasi energy spectrum remains elusive due to lack of knowledge of sufficiently many periodic orbits. Divergencies of periodic orbit formulas are avoided by appealing to the finiteness of the quantum mechanical Hilbert space. The traces also enter the coefficients of the characteristic polynominal of the Floquet operator. Statistical properties of these coefficients give rise to a new criterion for the distinction of chaos and regular motion.     

A unified conformal model for fundamental interactions without dynamical Higgs field

A Higgsless model for strong, electroweak and gravitational interactions is proposed. This model is based on the local symmetry group SU(3)×SU(2)_L×U(1)×C,where C is the local conformal symmetry group. The natural minimal conformally invariant form of total Lagrangian is postulated. It contains all standard model fields and gravitational interaction. Using the unitary gauge and the conformal scale fixing conditions, we can eliminate all four real components of the Higgs doublet in this model. However, the masses of vector mesons, leptons, and quarks are automatically generated and are given by the same formulas as in the conventional standard model. In this manner one gets the mass generation without the mechanism of spontaneous symmetry breaking and without the remaining real dynamical Higgs field. The gravitational sector is analyzed, and it is shown that the model admits in the classical limit the Einsteinian form of gravitational interactions.