A Novel Method for the Rapid Determination of Isonicotinic Hydrazide in Aqueous Solutions Using Reflectance Spectrophotometry and Colorimetry

A rapid method is developed for the quantitative determination of 5–35 g/L of isonicotinic hydrazide (INH, isoniazide) in aqueous media. The method is based on the formation of copper(I) oxide in the reaction of isonicotinic hydrazide with copper ions on the surface of indicator tablets and the subsequent recording of the analytical signal by reflectance spectrophotometry and colorimetry. Aluminum oxide is proposed as a solid-phase substrate for the production of indicator tablets. Isonicotinic hydrazide can be determined in the tablet form of the Isoniazid preparation.     

X-ray structural investigation of N-phenyl-N′-methoxydiazene-N-oxide

Conclusions Low temperature x-ray structural analysis of N-phenyl-N-methoxydiazene-N-oxide has revealed that the planar conjugated methoxydiazene oxide fragment exists in a Z-configuration with the phenyl substituent rotated about it by a 26° angle.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2516–2518, November, 1988.     

Spectral parameter asymptotics of the Weyl solutions of Sturm-Liouville equations

In the paper one investigates the dependence of Weyl's solution ,)=c(,)+n()s(,) of the Sturm-Liouville equation y+q()y=²y on the spectral parameter . Under the condition that the potential q is bounded from below and q()exp(c₀+c[in1 ¦¦), it is proved for {ie217-01} for any positive values and A. If q()>1 and {ie217-02} for all >0, then in the semiplane >0 the Weyl solution (, ) is obtained from the Weyl solution (,x) is obtained from the Weyl solution e^ix with zero potential, with the aid of a generalization of B. Ya Levin's transformation operators.Translated from Zapiski Nauchnykh Seminarov Leningradskogo Otdeleniya Matematicheskogo Instituta im. V. A. Steklova Akademii Nauk SSSR, Vol. 170, pp. 184–206, 1989.I express my sincere gratitude to L. A. Pastur and I. V. Ostrovskii for valuable advice and discussions.     

Temperature-dependent changes in erythrocytes' cytosol state during natural and artificial hypobiosis

At present, the question of how the structural state of the erythrocyte cytosol is arranged to maintain essential permeabilities successfully both at normal temperature and during periods with a significant body temperature reduction during hypobiosis remains unanswered. In the present work, we performed comparative investigations of temperature-dependent changes in the cytosol state of erythrocytes from animals subjected to natural (winter hibernating ground squirrels) or artificial hypobiosis. The cytosol state was evaluated by the ESR method of spin probes (TEMPON) within the temperature range of 0-50 degrees C. Erythrocyte resistance to acid hemolysis, which is limited by the permeability of membranes for protons and the state of the anion channel, were determined using the method described by Terskov and Getelson [Biofizika 2 (1957) 259]. A change in cytosol microviscosity of erythrocytes was found as well as a temperature-dependent increase in acid resistance of erythrocytes. Our investigations allow us to conclude that physiological changes occurring in a mammalian organism during natural and artificial hypobiosis are accompanied by structural modifications of the erythrocyte cytosol. The temperature range where these modifications are observed (8, 15, 40 degrees C) suggests that the most probable modifying link is spectrin and/or the sites of its interaction with membrane. The interaction of cytoskeletal components with the cell membrane plays a key role in regulation of membrane permeability, suggesting an important role of this interaction in the adaptive reactions of erythrocytes.     

On the theory of smectic textures

The strains in smectics are considered beyond the small-angle approximation. The energies of confocal and conical textures are determined.