Synthesis of furo[3,2-c]pyridine and furo[2,3-d]pyrimidine derivatives from butyrolactone diethylacetal

The reaction of butyrolactone acetal with CH acids was used to synthesize 2-methylenetetrahydrofuran derivatives. The latter react with dimethylformimide acetal to give a dieneamine that is capable of undergoing cyclization to furo [3,2-c]pyrimidine derivatives. This two-ring system was also synthesized by the reaction of cyanacetamide with 3-dimethylaminomethylenebutyrolactone acetal. The indicated acetal can also react with amidine components to give furo [2,3-d]pyrimidine derivatives.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 68–71, January, 1982.     

Influence of copper stearate on oxidation of polyethylene stabilized with Neozon D

Catalytic reaction of copper(II) stearate with Neozon D in a polyethylene melt was studied.Translated from Zhurnal Prikladnoi Khimii, Vol. 77, No. 9, 2004, pp. 1539–1542.Original Russian Text Copyright © 2004 by Lin, Vorobeva, Marchenko.     

Synthesis of 4-methyl-1H-imidazo[4,5-c]quinoline

A four-step synthesis of 4-methyl-1H-imidazo[4,5-c]quinoline from 2-methyl-3-nitro-4-oxo-1,4-dihydroquinoline is developed.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 231–232, February, 1989.     

Stereochemistry of the oxidation and alkylation of trans-1-alkyl-4-ethynyldecahydro-4-quinolols

The stereochemistry of the oxidation and alkylation of the nitrogen atom of trans-1-alkyl-4-ethynyldecahydro-4-quinolols was investigated. The orientation of the substitutents attached to the nitrogen atom in the synthesized N-oxides and quaternary salts was determined on the basis of the PMR spectra and previously obtained data on the stereochemistry of the oxidation of 4-substituted 1,3-dimethyldecahydro-4-quinolols.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 221–224, February, 1977.     

Pmr spectra and cis-trans isomerism of 2-methylenepyrrolidine and 2-methylenetetrahydrofuran derivatives

A number of secondary enamines and cyclic enol ethers (2-methylenetetrahydrofuran derivatives) were synthesized by the reaction of O-methylbutyrolactim and 2,2-diethoxytetrahydrofuran, respectively, with compounds that have an active methylene link. The absence of reversible cis-trans isomerization was established in a study of the PMR spectra of these compounds. The configuration of the secondary enamines is determined by the possibility of the formation of a strong intramolecular hydrogen bond between the carbonyl-containing substituent and the NH group. In the case of the cyclic enol ethers it was shown that the energy barrier to cis-trans isomerization is greater than 25 kcal/mole and that, as a consequence of this, the geometrical isomers can be separated preparatively.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 914–918, July, 1982.     

Acetals of lactams and acid amides

7-Dimethylamino-5-hydroxypyrido[2,3-d]pyrimidine and pyrrolo-, pyrido, and azepino [2,3-b]pyrido[2,3-d]pyrimidine derivatives were synthesized by reaction of acetals of amides and lactams with 4-amino-5-carbethoxypyrimidine derivatives and subsequent intramolecular cyclization of the intermediate amidines. The reactions of these compounds with phosphorus oxychloride and their alkylation reactions were studied.See [1] for communication XXVI.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1549–1554, November, 1978.     

New iron-containing antibiotics isolation and properties of viridomycins A, B, and C

Summary 1. New iron-containing antibiotics, viridomycins A, B, and C, have been isolated from the actinomyceteActinomyces viridaris.2. Deferriviridomycin A — the precursor of viridomycin A — possesses the capacity for binding not only iron ions but also cobalt, nickel, and copper ions. The copper, nickel, and cobalt analogs of viridomycin A have been obtained.M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 490–498, July–August, 1975.     

Influence of Copper on Oxidation of Polyethylene Containing Antioxidants

Thermal oxidation of polyethylene containing amine and phenolic antioxidants during contact with copper (metal support, powder) and the trends in variation of the antioxidant performance were studied.     

C-Thiocarbamoylation of Electron-Rich Heterocycles and Enamines with Amidophosphonium Isothiocyanates

Amidophosphonium isothiocyanates thiocarbamoylate a series of electron-rich heterocycles and enamines at the nucleophilic carbon atom to form phosphazothiocarbonyl compounds. From the most active heterocycles, bis(phosphazothiocarbonyl) derivatives can be obtained.