Stabilization of the Pro-Tyr-Gly-NH2 melanostatin analog on micelles

Inversed AOT micelles have been used as a system to simulate peptide-receptor interaction; they encapsulate an aqueous solution of the melanostatin analog HCl·Pro-Tyr-Gy-NH₂. NOESY indicates that adsorption at the phase boundary causes the peptide to acquire the biologically active _II conformation. The phenyl ring in Tyr is inserted into the cavity formed by the isooctyl moieties of the AOT molecules.Translated from Teoreticheskaya i Éksperimental'naya Khimiya, Vol. 29, No. 1, pp. 74–80, January–February, 1993.     

Local solvability of PDE with constant coefficients

The fundamental result of the paper consists in the following assertion: Let D be an open set in Rⁿ,f £ L₂(D), and let be a distribution in Rⁿ with a compact support, whose Fourier transform satisfies the condition

Substituent effects in the fragmentation reactions of acetanilides and phenyl acetates

The mass spectra of a group of m- and p-substituted acetanilides were measured to determine the effect of the substituents, if any, on the rate of C₂H₂O expulsion (rearrangement) vs. the rate of [CH₃CO]⁺ formation (simple cleavage). Our results agree with observations of others in that substituents which raise the ionization potential of the aromatic ring appear to localize, on the average, less charge density on this locus, and conversely. The atomic composition of the substituent, however, irrespective of its position, seems to determine the relative rates of the competing reaction. Although in several cases Z_m/Z_p values were close to unity, rearrangement of isomeric molecular ions to a common species is shown not to occur.