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91.
Hong H Park S Jiménez RH Rinehart D Tamm LK 《Journal of the American Chemical Society》2007,129(26):8320-8327
Aromatic residues are frequently found in helical and beta-barrel integral membrane proteins enriched at the membrane-water interface. Although the importance of these residues in membrane protein folding has been rationalized by thermodynamic partition measurements using peptide model systems, their contribution to the stability of bona fide membrane proteins has never been demonstrated. Here, we have investigated the contribution of interfacial aromatic residues to the thermodynamic stability of the beta-barrel outer membrane protein OmpA from Escherichia coli in lipid bilayers by performing extensive mutagenesis and equilibrium folding experiments. Isolated interfacial tryptophanes contribute -2.0 kcal/mol, isolated interfacial tyrosines contribute -2.6 kcal/mol, and isolated interfacial phenylalanines contribute -1.0 kcal/mol to the stability of this protein. These values agree well with the prediction from the Wimley-White interfacial hydrophobicity scale, except for tyrosine residues, which contribute more than has been expected from the peptide models. Double mutant cycle analysis reveals that interactions between aromatic side chains become significant when their centroids are separated by less than 6 A but are nearly insignificant above 7 A. Aromatic-aromatic side chain interactions are on the order of -1.0 to -1.4 kcal/mol and do not appear to depend on the type of aromatic residue. These results suggest that the clustering of aromatic side chains at membrane interfaces provides an additional heretofore not yet recognized driving force for the folding and stability of integral membrane proteins. 相似文献
92.
A. Jilek A. Ryánek A. del Campe F. Sierra F. Feigl P. Krumholz L. Guglialmelli J. Lukas Marianne Papafil R. Cernatesco I. Itaka Y. Aoki und W. Stahl 《Fresenius' Journal of Analytical Chemistry》1934,98(7-8):292-298
Ohne Zusammenfassung 相似文献
93.
Péter Reischig Lukas Helfen Arie Wallert Tilo Baumbach Joris Dik 《Applied Physics A: Materials Science & Processing》2013,111(4):983-995
The characterisation of the microstructure and micromechanical behaviour of paint is key to a range of problems related to the conservation or technical art history of paintings. Synchrotron-based X-ray laminography is demonstrated in this paper to image the local sub-surface microstructure in paintings in a non-invasive and non-destructive way. Based on absorption and phase contrast, the method can provide high-resolution 3D maps of the paint stratigraphy, including the substrate, and visualise small features, such as pigment particles, voids, cracks, wood cells, canvas fibres etc. Reconstructions may be indicative of local density or chemical composition due to increased attenuation of X-rays by elements of higher atomic number. The paint layers and their interfaces can be distinguished via variations in morphology or composition. Results of feasibility tests on a painting mockup (oak panel, chalk ground, vermilion and lead white paint) are shown, where lateral and depth resolution of up to a few micrometres is demonstrated. The method is well adapted to study the temporal evolution of the stratigraphy in test specimens and offers an alternative to destructive sampling of original works of art. 相似文献
94.
UV‐Free Microfluidic Particle Fabrication at Low Temperature Using ARGET‐ATRP as the Initiator System 下载免费PDF全文
A new way to fabricate monodisperse polymer particles in a microfluidic device without UV‐light and without the need for high temperatures is described in this article. By applying an activator regeneration by electron transfer ‐ atom transfer radical polymerization (ARGET‐ATRP) initiator system in a co‐capillary microfluidic setup and by separating the monomer mixture in an initiator and a catalyst phase, a fast polymerization of the droplets at low temperature without premature curing and thus clogging of the capillaries can be achieved. The influence of the flow rates on the particle sizes and their polydispersity as well as the controlled character of the polymerization are investigated. The particle size is well adjustable, but the reaction is not controlled due to the high radical concentration needed for rapid polymerization. In addition, particles with incorporated UV‐dyes are produced as a proof of concept at low temperature.
95.
Selective reagent ionisation‐time of flight‐mass spectrometry: a rapid technology for the novel analysis of blends of new psychoactive substances 下载免费PDF全文
Matteo Lanza W. Joe Acton Philipp Sulzer Kostiantyn Breiev Simone Jürschik Alfons Jordan Eugen Hartungen Gernot Hanel Lukas Märk Tilmann D. Märk Chris A. Mayhew 《Journal of mass spectrometry : JMS》2015,50(2):427-431
In this study we demonstrate the potential of selective reagent ionisation‐time of flight‐mass spectrometry for the rapid and selective identification of a popular new psychoactive substance blend called ‘synthacaine’, a mixture that is supposed to imitate the sensory and intoxicating effects of cocaine. Reactions with H3O+ result in protonated parent molecules which can be tentatively assigned to benzocaine and methiopropamine. However, by comparing the product ion branching ratios obtained at two reduced electric field values (90 and 170 Td) for two reagent ions (H3O+ and NO+) to those of the pure chemicals, we show that identification is possible with a much higher level of confidence then when relying solely on the m/z of protonated parent molecules. A rapid and highly selective analytical identification of the constituents of a recreational drug is particularly crucial to medical personnel for the prompt medical treatment of overdoses, toxic effects or allergic reactions. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
96.
The characteristics of a manufacturing product are influenced by a variety of different factors, such as the material properties of the base product. The prediction of properties that give optimal results in metal forming applications is a complex task but of high interest for the manufacturer. To realize such a prediction scheme, the process chain is split up into individual process steps and for each of them an inverse modeling is required. The specific aim of this work is to present an approach for the inverse problem formulation of a process step and to solve it using methods of machine learning. Moreover, the challenges that often arise due to the ill-posed nature of inverse problems will be discussed. The main focus is on the crystallographic texture of metals, which strongly affects the deformation behavior during a process step and highly influences the characteristics of the final product. (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
97.
In this short note, we give a characterization of domains satisfying Serre’s condition (R1) in terms of their canonical modules. In the special case of toric rings, this generalizes a result of the second author [9] where the normality is described in terms of the “shape” of the canonical module. 相似文献
98.
Susan Torabi Lukas Hammerschmidt Elena Voloshina Beate Paulus 《International journal of quantum chemistry》2014,114(14):943-951
The performance of wavefunction‐based correlation methods in theoretical solid‐state chemistry depends on reliable Hartree–Fock (HF) results for infinitly extended systems. Therefore, we optimized basis sets of valence‐triple‐ζ quality based on HF calculations for the periodic system of group‐12‐metal difluorides. Scalar‐relativistic effects were included in the case of the metal‐ions by applying small‐core pseudopotentials. To assess the quality of the proposed basis sets, the structural parameters, bulk moduli as well as cohesive and lattice energies of the systems were evaluated at the HF and the density functional theory levels. In addition to these two mean‐field approaches and to assess further employment of our basis sets to wavefunction‐based correlation methods we performed periodic local MP2 computations. Finally, the possibilities of pressure induced structural phase transitions occurring in the ZnF2, CdF2, and HgF2 were investigated. © 2014 Wiley Periodicals, Inc. 相似文献
99.
Structural stability is an important issue to ensure the safety of thin walled structures. Shell structures are considered in context of linear and non-linear buckling. The design sensitivity analysis with respect to modifications in shape is motivated. Analytically derived gradient information is employed for shape optimisation purposes using solid shells. (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
100.