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101.
Ricard Herrera Lourdes Franco Alfonso Rodríguez‐Galn Jordi Puiggalí 《Journal of polymer science. Part A, Polymer chemistry》2002,40(23):4141-4157
Random copolyesters based on 1,4‐butanediol and different ratios between adipic and terephthalic units were synthesized from thermal polycondensation of the appropriate mixture of monomers or by melt transesterification of the mixture of homopolymers. 1H NMR spectroscopy makes feasible the study of the average block lengths of polymers once synthesized and after degradation in different media. Calorimetric data are reported, including those referred to the study of isothermal and nonisothermal crystallizations. Degradability of samples was evaluated by different methods including NMR and thermal analysis, evaluation of molecular weight by gel permeation chromatography or from intrinsic viscosity measures, scanning electron micrographs, and changes in mechanical properties. Distilled water at 70 °C acidic conditions provided by a pH 2.3 aqueous medium and enzymatic media containing lipases from Pseudomonas cepacia or Candida cylindracea were considered in this study. The degradability of the studied copolyesters strongly depends on the terephthalate content and the degradation media. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 4141–4157, 2002 相似文献
102.
Solid-phase microextraction coupled with high-performance liquid chromatography for the analysis of heterocyclic aromatic amines 总被引:3,自引:0,他引:3
Solid-phase microextraction (SPME) coupled with high-performance liquid chromatography (HPLC) with UV diode array detection (DAD) for the analysis of heterocyclic aromatic amines (HAs) is described. Four kinds of fiber coatings: Carbowax-templated resin (CW-TPR), Carbowax-divinylbenzene (CW-DVB), poly(dimethylsiloxane)-divinylbenzene (PDMS-DVB) and polyacrylate (PA) were evaluated for extraction of nine most biologically active heterocyclic aromatic amines. Different parameters affecting to the microextraction and determination of HAs were studied, such as absorption and desorption time, desorption mode, composition of the solvent for desorption, pH, ionic strength, and percentage of methanol in the sample. To determine these amines in food samples a new simplified procedure is proposed, consisting of treatment of the sample with methanolic NaOH prior microextraction by CW-TPR fiber coating and HPLC-DAD determination. The advantages of this new method are the reduced amounts of time and organic solvents required. 相似文献
103.
Prieto M Zurita E Rosa E Muñoz L Lloyd-Williams P Giralt E 《The Journal of organic chemistry》2004,69(20):6812-6820
Yields of Suzuki couplings involving indoles depended upon (i) whether arylboronic acids or arylpinacolboronate esters were used, (ii) whether the heterocycle was the aryl halide or the arylboron coupling partner, and (iii) whether the heterocycle was protected or not. Highest yields, which were unaffected by incorporating Boc or Tos protection at the heterocyclic nitrogen, were obtained when indole bromides were reacted with phenylboronic acids. When indolylboronic acids were reacted with phenyl bromides, yields were somewhat lower and depended on the nitrogen substituent, being highest in the absence of protection, lower in the presence of the Boc group, and lowest of all with the Tos group. Arylpinacolboronate esters were less reactive than arylboronic acids. They required considerably longer reaction times and furnished generally lower yields of biaryl. Furthermore, irrespective of whether the heterocycle was the aryl bromide or the arylpinacolboronate ester, these yields were highest when it was protected with the Tos group. Yields were lower with the Boc group, and unprotected heterocycles gave only traces of biaryl. Careful selection of arylboron reagent, of coupling partner roles, and of protecting groups are essential to ensuring optimum results in these Suzuki couplings. These results may also be relevant to couplings involving other substrates. 相似文献
104.
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106.
Margarita Juárez-Montiel J. Antonio Ibarra Griselda Chávez-Camarillo César Hernández-Rodríguez Lourdes Villa-Tanaca 《Applied biochemistry and biotechnology》2014,172(5):2530-2539
Dipeptidyl aminopeptidases are enzymes involved in the posttranslational control of bioactive peptides. Here we identified the gene dapUm in Ustilago maydis by homology with other fungal dipeptidyl aminopeptidases. Analysis of the dapUm-deduced amino acid sequence indicated that it encodes for membrane-type serine protease with a characteristic prolyl oligopeptidase catalytic motif triad: Ser, Asp, His. In order to overexpress the DapUm, the gene encoding for it was cloned and transformed into Pichia. Using this system, we observed a ~125-kDa recombinant protein with an optimal enzymatic activity at pH 6.0 and at 40 °C for the Ala-Pro-p-nitroanilide substrate and an experimental pH of 6.9. U. maydis DapUm was specifically inhibited by phenylmethylsulfonyl fluoride and Pefabloc, confirming the presence of a serine residue in the active site. To our knowledge, this study is the first report on the cloning and expression of a DPP IV dipeptidyl aminopeptidase from a basidiomycete organism. Moreover, the use of recombinant DapUm will allow us to further study and characterize this enzyme, in addition to testing chemical compounds for pharmaceutical purposes. 相似文献
107.
Effect of Hydrodynamic Forces on meso‐(4‐Sulfonatophenyl)‐Substituted Porphyrin J‐Aggregate Nanoparticles: Elasticity,Plasticity and Breaking
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Dr. Zoubir El‐Hachemi Prof. Teodor Silviu Balaban Dr. J. Lourdes Campos Sergio Cespedes Dr. Joaquim Crusats Dr. Carlos Escudero Dr. Christina S. Kamma‐Lorger Prof. Joan Llorens Dr. Marc Malfois Prof. Geoffrey R. Mitchell Dr. Ana P. Tojeira Prof. Josep M. Ribó 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(28):9740-9749
The J aggregates of 4‐sulfonatophenyl meso‐substituted porphyrins are non‐covalent polymers obtained by self‐assembly that form nanoparticles of different morphologies. In the case of high aspect‐ratio nanoparticles (bilayered ribbons and monolayered nanotubes), shear hydrodynamic forces may modify their shape and size, as observed by peak force microscopy, transmission electron microscopy of frozen solutions, small‐angle X‐ray scattering measurements in a disk‐plate rotational cell, and cone–plate rotational viscometry. These nanoparticles either show elastic or plastic behaviour: there is plasticity in the ribbons obtained upon nanotube collapse on solid/air interfaces and in viscous concentrated nanotube solutions, whereas elasticity occurs in the case of dilute nanotube solutions. Sonication and strong shear hydrodynamic forces lead to the breaking of the monolayered nanotubes into small particles, which then associate into large colloidal particles. 相似文献
108.
Lourdes Cucurull-Sanchez 《Journal of computer-aided molecular design》2010,24(5):449-458
The results of a new method developed to identify well defined structural transformations that are key to improve a certain ADME profile are presented in this work. In particular Naïve Bayesian statistics and SciTegic FCFP_6 molecular fingerprints have been used to extract, from a dataset of 1,169 compounds with known in vitro UGT glucuronidation clearance, those changes in chemical structure that lead to a significant increase in this property. The effectiveness in achieving that goal of the thus found 55,987 transformations has been quantified and compared to classical medicinal chemistry transformations. The conclusion is that on average the new transformations found via in silico methods induce increases of UGT clearance by twofold, whilst the classical transformations are on average unable to alter that endpoint significantly in any direction. When both types of transformations are combined via substructural searches (SSS) the average twofold increase in glucuronidation is maintained. The implications of these findings for the drug design process are also discussed, in particular when compared to other methods previously described in the literature to address the question ‘Which compound do I make next?’ 相似文献
109.
Hilda R. Morales Martín Pérez-Juárez Laura Cuéllar Lourdes Mendoza Héctor Fernández Rosalinda Contreras 《合成通讯》2013,43(13):1213-1219
A new procedure for the high-yield N-monoalkylation of primary aromatic and aliphatic amines is described. 相似文献
110.