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51.
K. E. Mochalov O. A. Ustinova S. A. Strel’tsov S. L. Grokhovskii A. L. Zhuze I. R. Nabiev A. V. Sukhanova V. A. Oleinikov 《Optics and Spectroscopy》2002,93(4):493-500
Topotecan (TPT), a water-soluble derivative of camptothecin (inhibitor of human DNA topoiomerase I), has found wide application in cancer chemotherapy. The central problem in using topotecan is the presence of lactone rings in its molecules, which undergo hydrolysis at a physiological pH yielding an inactive and even toxic form of the drug. The analysis of Raman spectra of TPT in H2O and D2O solutions made it possible to assign the spectral bands to the vibrations of particular molecular groups. Spectral features indicative of the opening of the lactone rings of the TPT molecules, deprotonation of the hydroxyl groups in their quinoline fragments, and of possible participation of the hydroxyl and carbonyl groups in H bonding are found. The data obtained are necessary to study the molecular mechanisms of TPT-DNA interaction and the formation of ternary complexes between TPT, DNA, and DNA topoisomerase I. 相似文献
52.
The existence of linear nonstationary optical resonances in a diatomic nanostructural object with a dipole-dipole atomic interaction has been proved. A new solution to the joint system of modified Bloch optical equations and nonlocal field equations is obtained for time intervals much shorter than the times of phase and energy relaxation. Formulas for effective polarizabilities of the object’s atoms, which have a set of dimensional resonances, are derived. The frequencies of these resonances significantly differ from the eigenfrequencies of the object’s atoms, and their properties depend on the interatomic distance, light-pulse duration, initial atomic inversions, and the orientation of the object’s axis relative to the direction of incidence of the external light wave. 相似文献
53.
We use the adiabatic hyperspheric expansion and the Faddeev decomposition of the wave function with only s-waves. We derive for a fixed hyperradius an integro-differential equation for the angular eigenvalue and wave function. The
correlations lower the interaction energy for N = 20 by about a factor of 5.
Received October 22, 2001; accepted for publication November 5, 2001 相似文献
54.
55.
A. G. Artukh G. F. Gridnev M. Gruszecki F. Koscielniak A. G. Semchenkov O. V. Semchenkova Yu. M. Sereda J. Szmider Yu. G. Teterev 《Physics of Atomic Nuclei》2002,65(3):393-399
A systematic investigation of the forward-angle inclusive yields of 2≤Z≤11 isotopes produced in collisions of 18O projectile nuclei with a 9Be target in the Fermi energy region (35A MeV) is performed. The measurements were based on the use of the COMBAS double achromatic kinematical separator in the spectrometry mode at the Flerov Laboratory of Nuclear Reactions at the Joint Institute for Nuclear Research, FLNR (JINR, Dubna). The velocity, isotopic, and element distributions are presented. There is no unique mechanism that would explain the total set of results obtained in this experiment. A dominant role of low-energy reaction mechanisms is observed. The intensity of secondary beams of halolike nuclei 11Li, 12Be, and 14Be is determined. 相似文献
56.
O. Kortner M.P. Locher V.E. Markushin P. Weber O. Wigger 《The European Physical Journal C - Particles and Fields》2002,25(3):353-360
We study correlations in the exclusive reaction at rest with complete reconstruction of the kinematics for each event. The inclusive distribution is fairly flat at small
invariant mass of the pion pair while a small enhancement in the double differential distribution is observed for small invariant
masses of both pion pairs. Dynamical models with resonances in the final state are shown to be consistent with the data while
the stochastic HBT mechanism is not supported by the present findings.
Received: 26 February 2002 / Revised version: 22 July 2002 / Published online: 30 August 2002 相似文献
57.
58.
凯尔文电桥是国内大学基础物理实验所开设的实验内容之一,且多为自组式.关于自组凯尔文电桥的测量精度与桥路参数精度之间的关系,有些实验教材已有推导,但尚未涉及与两低阻相邻电压接头间跨桥电阻的定量关系,不注意这一点,会给测量结果带来一定的误差.本文就实际中常用的等双臂凯尔文电桥从理论上定量地推出了这一关系,进而给出了跨桥电阻可忽略时的适当阻值. 相似文献
59.
Liyue Liu Yingge Yang Yafei Zhang 《Physica E: Low-dimensional Systems and Nanostructures》2004,24(3-4):343-348
The electrical conductivity was investigated for multi-walled carbon nanotubes (MWNTs) dissolved in chloroform and toluene, respectively. The electrical conductivity remarkably increased with increase in the content of MWNTs, which is in accordance with Archie's equation . Furthermore, a hypothesis of the electronic transport process was proposed to explain the difference between the solution and the solid compound. In addition, the temperature dependence of the electrical conductivity shows that log σ vs. 1/T exist in a good linear relationship. The activation energy of the electrical conductivity decreased with increase in concentration and an inflexion was observed at 60 °C in MWNT/toluene solution. 相似文献
60.
I. V. Denisova O. A. Ladyzhenskaya G. A. Seregin N. N. Uraltseva E. V. Frolova 《Journal of Mathematical Sciences》2005,130(4):4775-4779
Bibliography: 42 titles.__________Translated from Zapiski Nauchnykh Seminarov POMI, Vol. 306, 2003, pp. 7–15. 相似文献