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排序方式: 共有94条查询结果,搜索用时 15 毫秒
21.
Lilly MJ Miller NA Edwards AJ Willis AC Turner P Paddon-Row MN Sherburn MS 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(8):2525-2536
The stereochemical outcome of the intramolecular Diels-Alder reaction of ester-linked 1,3,8-nonatrienes can be controlled by substituents about a stereogenic center attached to C1. The scope and limitations of this approach have been investigated, with variation in substrate structure about the allylic stereocenter and the dienophile. The stereochemical outcomes of these reactions are explained by reference to B3 LYP/6-31G(d) transition structures. New insights into the conformational preferences of allylic alcohol derivatives are reported, results which allow an explanation of the differing levels of pi-diastereofacial selectivity and cis/trans (i.e. endo/exo) selectivity from the reaction. 相似文献
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L.A. Tracy K. Eng K. Childs M.S. Carroll M.P. Lilly 《Solid State Communications》2010,150(5-6):231-234
We report the density and magnetic field dependence of the valley splitting of two-dimensional electrons in (100) Si metal–oxide–semiconductor field-effect transistors, as determined via activation measurements in the quantum Hall regime. We find that the valley activation gap can be greatly enhanced at high magnetic fields as compared to the bare valley splitting. The observation of strong dependence of the valley activation gap on orbital Landau level occupancy and similar behavior of nearby spin gaps suggest that electron–electron interactions play a large role in the observed enhancement. 相似文献
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Martin Brodrecht Bharti Kumari Dr. A. S. Sofia Lilly Thankamony Dr. Hergen Breitzke Dr. Torsten Gutmann Prof. Dr. Gerd Buntkowsky 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(20):5214-5221
The structure and surface functionalization of biologically relevant silica-based hybrid materials was investigated by 2D solid-state NMR techniques combined with dynamic nuclear polarization (DNP). This approach was applied to a model system of mesoporous silica, which was modified through in-pore grafting of small peptides by solid-phase peptide synthesis (SPPS). To prove the covalent binding of the peptides on the surface, DNP-enhanced solid-state NMR was used for the detection of 15N NMR signals in natural abundance. DNP-enhanced heterocorrelation experiments with frequency switched Lee–Goldburg homonuclear proton decoupling (1H–13C and 1H–15N CP MAS FSLG HETCOR) were performed to verify the primary structure and configuration of the synthesized peptides. 1H FSLG spectra and 1H-29Si FSLG HETCOR correlation spectra were recorded to investigate the orientation of the amino acid residues with respect to the silica surface. The combination of these NMR techniques provides detailed insights into the structure of amino acid functionalized hybrid compounds and allows for the understanding for each synthesis step during the in-pore SPPS. 相似文献
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Ohne Zusammenfassung 相似文献
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Pei Y Lilly MJ Owen DJ D'Souza LJ Tang XQ Yu J Nazarbaghi R Hunter A Anderson CM Glasco S Ede NJ James IW Maitra U Chandrasekaran S Moos WH Ghosh SS 《The Journal of organic chemistry》2003,68(1):92-103
Type II diabetes mellitus is a chronic metabolic disorder that can lead to serious cardiovascular, renal, neurologic, and retinal complications. While several drugs are currently prescribed to treat type II diabetes, their efficacy is limited by mechanism-related side effects (weight gain, hypoglycemia, gastrointestinal distress), inadequate efficacy for use as monotherapy, and the development of tolerance to the agents. Consequently, combination therapies are frequently employed to effectively regulate blood glucose levels. We have focused on the mitochondrial sodium-calcium exchanger (mNCE) as a novel target for diabetes drug discovery. We have proposed that inhibition of the mNCE can be used to regulate calcium flux across the mitochondrial membrane, thereby enhancing mitochondrial oxidative metabolism, which in turn enhances glucose-stimulated insulin secretion (GSIS) in the pancreatic beta-cell. In this paper, we report the facile synthesis of benzothiazepines and derivatives by S-alkylation using 2-aminobenzhydrols. The syntheses of other bicyclic analogues based on benzothiazepine, benzothiazecine, benzodiazecine, and benzodiazepine templates are also described. These compounds have been evaluated for their inhibition of mNCE activity, and the results from the structure-activity relationship (SAR) studies are discussed. 相似文献
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