Reaction‐Based Colorimetric and Ratiometric Fluorescence Sensor for Detection of Cyanide in Aqueous Media

A stilbene‐based compound ( 1 ) has been prepared and was highly selective for the detection of cyanide anion in aqueous media even in the presence of other anions, such as F^?, Cl^?, Br^?, I^?, ClO₄^?, H₂PO₄^?, HSO₄^?, NO₃^?, and CH₃CO₂^?. A noticeable change in the color of the solution, along with a prominent fluorescence enhancement, was observed upon the addition of cyanide. The color change was observed upon the nucleophilic addition of the cyanide anion to the electron‐deficient cyanoacrylate group of 1 . The spectral changes induced by the reaction were analyzed by comparison with two model compounds, such as compound 2 with dimethyl substituents and compound 3 without a cyanoacrylate group. An intramolecular charge‐transfer (ICT) mechanism played a key role in the sensing properties, and the mechanism was supported by DFT/TDDFT calculations.     

Cross-sectional investigation of correlation between hepatic steatosis and IVIM perfusion on MR imaging

The purpose of this study was to investigate the relationship between liver fat fraction (FF) and diffusion parameters derived from the intravoxel incoherent motion (IVIM) model. Thirty-six subjects with suspected nonalcoholic fatty liver disease underwent diffusion-weighted magnetic resonance imaging with 10 b-values and spoiled gradient recalled echo imaging with six echoes for fat quantification. Correlations were measured between FF, transverse relaxivity (R2), diffusivity (D) and perfusion fraction (f). The primary finding was that no significant correlation was obtained for D vs. FF or f vs. FF. Significant correlations were obtained for D vs. R2 (r=-0.490, P=.002) and f vs. D (r=-0.458, P=.005). The conclusion is that hepatic steatosis does not affect measurement of perfusion or diffusion and therefore is unlikely to confound the use of apparent diffusivity to evaluate hepatic fibrosis.     

Probing the intrachain and interchain effects on the fluorescence behavior of pentiptycene-derived oligo(p-phenyleneethynylene)s

The synthesis, crystal structure, and fluorescence behavior of acetylene-bridged pentiptycene dimer (2), trimer (3), and tetramer (4) are reported. For comparison, a phenylene-pentiptycene-phenylene three-ring system (5) is also investigated. As a result of the unique intrachain pentiptycene-pentiptycene interactions in 3 and 4, their twisted conformers are populated in polar solvents and at low temperatures, and the phenomenon of nonequilibration of excited rotational conformers is observed. Twisting of the pi-conjugated backbones leads to blue-shifted absorption and fluorescence spectra and increased fluorescence quantum yields and lifetimes. The fluorescence spectra of 2-4 undergo small red shifts but large intensity variations in the 0-1 vs 0-0 bands on going from solutions to thin solid films, which can be accounted for by the reabsorption effect. However, the reduction in fluorescence quantum yields for 2-4 in films vs solutions is mainly attributed to efficient interchain exciton migration to nonfluorescent energy traps. In contrast, the behavior of nonequilibration of excited rotamers is not observed for 5 in solutions. Compound 5 forms J-type aggregates through terminal phenylene pi-stackings in the solid state, resulting in a new absorption band at 377 nm and large red shifts of the structured fluorescence spectra.     

Preparation of entangled states of atomic qubits via atom-cavity-laser interaction

<正>We propose a scheme to prepare the Bell states for atomic qubits trapped in separate optical cavities via atom-cavity-laser interaction.The quantum information of each qubit is encoded on the degenerate ground states of the atom,so the entanglement between them is relatively stable against spontaneous emission.The proposed scheme consists of a Mach-Zehnder interferometer(MZI) with two arms,and each arm contains a cavity with an N-type atom in it.It requires two classical fields and a single-photon source. By controlling the sequence and time of atom-cavity-laser interaction,the deterministic production of the atomic Bell states is shown.We also introduce the generalization of the present scheme to generate the 2N-atom Greenberger-Horne-Zeilinger state.     

Design of survivable IP-over-optical networks

In the past years, telecommunications networks have seen an important evolution with the advances in optical technologies and the explosive growth of the Internet. Several optical systems allow a very large transport capacity, and data traffic has dramatically increased. Telecommunications networks are now moving towards a model of high-speed routers interconnected by intelligent optical core networks. Moreover, there is a general consensus that the control plan of the optical networks should utilize IP-based protocols for dynamic provisioning and restoration of lightpaths. The interaction of the IP routers with the optical core networks permits to achieve end-to-end connections, and the lightpaths of the optical networks define the topology of the IP network. This new infrastructure has to be sufficiently survivable, so that network services can be restored in the event of a catastrophic failure. In this paper we consider a multilayer survivable network design problem that may be of practical interest for IP-over-optical neworks. We give an integer programming formulation for this problem and discuss the associated polytope. We describe some valid inequalities and study when these are facet defining. We discuss separation algorithms for these inequalities and introduce some reduction operations. We develop a Branch-and-Cut algorithm based on these results and present extensive computational results.     

Gram-scale synthesis of the A'B'-subunit of angelmicin B

A gram-scale enantiospecific synthesis of the A'B'-subunit of angelmicin B is reported. The synthesis involves a Lewis acid catalyzed contrasteric Diels-Alder reaction and a tandem silyl zincate 1,6-addition/enolate oxidation sequence.     

Generalized Lie derivations on skew elements of prime algebras with involution

We characterize generalized Lie derivations on skew elements of prime algebras A with involution, provided that A does not satisfy polynomial identities of low degree. The analogous result for matrix algebras is also described.     

Evaluation of MRI fat fraction in the liver and spine pre and post SPIO infusion

This study evaluates the robustness of a magnetic resonance (MR) fat quantification method to changes in R2* caused by an intravenous infusion of superparamagnetic iron oxide (SPIO) contrast agent. The R2* and proton density fat fraction (PDFF) were measured in liver and spine in 14 subjects using an investigational sequence (IDEAL IQ) provided by the MR scanner vendor. Measurements were made before and after SPIO infusion. Results showed SPIO significantly increased R2* in both liver (p = 8.8 × 10^− 8) and spine (p =1.3 × 10^− 2) but PDFFs were not significantly different in either the liver (p = 5.5 × 10^− 1) or the spine (p = 5.6 × 10^− 1). These results confirm that the IDEAL IQ method of fat quantification is robust to changes in R2*.     

Versatile Synthetic Route to Cycloheximide and Analogues That Potently Inhibit Translation Elongation

Cycloheximide (CHX) is an inhibitor of eukaryotic translation elongation that has played an essential role in the study of protein synthesis. Despite its ubiquity, few studies have been directed towards accessing synthetic CHX derivatives, even though such efforts may lead to protein synthesis inhibitors with improved or alternate properties. Described here is the total synthesis of CHX and analogues, and the establishment of structure–activity relationships (SAR) responsible for translation inhibition. The SAR studies aided the design of more potent compounds, one of which irreversibly blocks ribosomal elongation, preserves polysome profiles, and may be a broadly useful tool for investigating protein synthesis.     

Substituent-dependent photoinduced intramolecular charge transfer in N-aryl-substituted trans-4-aminostilbenes

The photochemical behavior of trans-4-(N-arylamino)stilbene (1, aryl = 4-substituted phenyl) in solvents more polar than THF is strongly dependent on the substituent in the N-aryl group. This is attributed to the formation of a twisted intramolecular charge transfer (TICT) state for those with a methoxy (1OM), methoxycarbonyl (1CO), or cyano (1CN) substituent but not for those with a methyl (1Me), hydrogen (1H), chloro (1Cl), or trifluoromethyl (1CF) substituent. On the basis of the ring-bridged model compounds 3-6, the TICT states for 1CN and 1CO result from the twisting of the anilino-benzonitrilo C-N bond, but for 1OM it is from the twisting of the stilbenyl-anilino C-N bond, both of which are distinct from the TICT states previously proposed for N,N-dimethylaminostilbenes.