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211.
Ferreira MC Brito VN Gameiro J Costa MR Vasconcellos EC Cruz-Hofling MA Verinaud L 《Journal of photochemistry and photobiology. B, Biology》2006,84(2):141-149
Paracoccidioidomycosis (PCM) is the most prevalent human mycosis in Latin America. The infection is thought to take place firstly in the lungs and then may disseminate to other organs and tissues. Treatment by currently available antifungals is lengthy, the drugs may have undesirable side effects, and some are costly. Occasional resistant strains of Paracoccidioides brasiliensis, the causative agent of PCM, have been reported. So, the search for more efficient treatments or adjuvant therapies has to be continued. In this work, we evaluated the effects of HeNe laser irradiation on cutaneous inflammatory lesions caused by the inoculation of 5 x 10(6)/0.1ml yeasts cells into the back footpad of Balb/c mice. HeNe irradiation (lambda=632.8nm, 3mW, incident energy of 3J/cm(2)) was applied at days 7, 8 and 9 post-infection and histological and immunohistochemical analysis were done. Unirradiated animals were used as controls. The results showed that laser-treated mice presented reduction of footpad edema, faster cutaneous wound healing, confluent granuloma, diffuse- and more loosely distributed immunolabeling for TNF-alpha, enhanced labeling of IFN-gamma and any P. brasiliensis form detected, whereas multiple viable fungi were seen in diffuse widespread granulomas obtained from non-treated mice foot-pad. Fungi that were harvested from laser-treated animals presented no capability of growth in vitro as compared to those obtained from non-treated mice. We conclude that HeNe laser irradiation was able to inhibit the progress of inflammatory local reaction produced by P. brasiliensis infection and influence local cytokines production. We suggest that this treatment modality can be a useful coadjuvant tool to be combined with antifungal agents in the treatment of PCM ulcerations. The mechanisms involved in laser therapy of PCM lesions need further investigation. 相似文献
212.
Liana Annunziata Consiglia Tedesco Claudio Pellecchia 《Journal of organometallic chemistry》2006,691(8):1505-1514
The synthesis of new organotin compounds of general formula Tip2SnRR′ (Tip = 2,4,6-triisopropylbenzene; R = R′ = CH3 (1); R = R′ = CHCH2 (2); R = CH2Ph, R′ = Br (3); R = R′ = CH2CHCH2 (4)) is described herein. The compounds have been characterized by 1H, 13C, 119Sn NMR, mass spectroscopy and elemental analysis. Characterization by single-crystal X-ray diffraction analysis has been obtained for compounds 2, 3 and 4. The reactivity with ionizing agents has been studied by NMR spectroscopy. Compounds 2 and 4 underwent alkyl abstraction by [(CH3CH2)3Si]+[B(C6F5)4]− affording stable cationic species (2a, 4a). For the cationic specie 4a a π-interaction of the benzyl group to the metal centre was recognized by solution NMR studies. A cationic species (3a) was generated from compound 3 using AgSbF6 as ionizing agent. The cationic species (2a, 3a) exhibited moderate activity as initiator in the cationic polymerization of 1,4-butadiene and good activity in the ring opening polymerization (ROP) of propylene oxide and ε-caprolactone. 相似文献
213.
Necessary and sufficient conditions for a point to be a weak saddle point of a vector valued function (i.e. to be a solution of the vector saddle point problem) are given. Also, an existence result for a vector saddle point to have a solution is given. 相似文献
214.
Ovari Tamara-Rita Katona Gabriel Coros Maria Szabó Gabriella Muresan Liana Maria 《Journal of Solid State Electrochemistry》2023,27(7):1795-1811
Journal of Solid State Electrochemistry - The aim of the paper is to carry out a detailed investigation of the effect of graphene oxide-poly(amidoamine) (GO-PAMAM) incorporated in silica matrices... 相似文献