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排序方式: 共有214条查询结果,搜索用时 15 毫秒
91.
The present work concerns the realisation of an equipment suitable for the choice of surfactants to be employed in the remediation of polluted soils by soil washing processes. The experimental activity has been focused to verify the surfactants efficiency in electrokinetic processes applied in low porosity soils, polluted with used vehicle oil. The equipment consents to estimate low electroosmotic permeabilities, electrical current and to analyse the electrolytic solutions. The concentration of the chemical species reached in both anodic and cathodic cells allows a more accurate evaluation of the ion mobility through the soil. The apparatus realised has been shown to be a useful instrument capable of providing directions for the choice of surfactants in electrokinetic soil remediation. The choice of an anionic surfactant for the oil removal has shown promising result. 相似文献
92.
A venerable scaffold for asymmetric synthesis and drug development, chiral 5-substituted oxazolidinones are obtained in almost enantiomerically pure form (up to 99.9% ee) starting from racemic terminal epoxides. The salient features of this process include the very simple and convenient experimental protocol and the employment of a readily accessible catalyst and inexpensive, easily handled starting materials. An enantioconvergent approach for the total conversion of racemic epoxide into a single stereoisomeric oxazolidinone is also described. 相似文献
93.
Optimized contracted Gaussian basis sets of double-zeta valence polarized (DZVP) quality for first-row transition metals are presented. The DZVP functions were optimized using the PWP86 generalized gradient approximation (GGA) functional and the B3LYP hybrid functional. For a careful analysis of the basis sets performance the transition metal atoms and cations excitation energies were calculated and compared with the experimental ones. The calculated values were also compared with those obtained using the previously available DZVP basis sets developed at the local-density functional level. Because the new basis sets work better than the previous ones, possible reasons of this behavior are analyzed. The newly developed basis sets also provide a good estimation of other atomic properties such as ionization energies. 相似文献
94.
M. Letizia Ciavatta M. Pilar Lopez Gresa Margherita Gavagnin Guido Cimino 《Tetrahedron letters》2004,45(41):7745-7748
Two new compounds, pregnanes 1 and 2, the known pregnane 3 and a series of known chlorinated prostanoids (4-9) have been isolated from the Indian octocoral Carijoa sp. Their structures have been elucidated by spectroscopic methods, mainly by 1D and 2D NMR. The new compounds were potent inhibitors of the mitochondrial respiratory chain. 相似文献
95.
Cusumano M Di Pietro ML Giannetto A Nicolò F Nordén B Lincoln P 《Inorganic chemistry》2004,43(7):2416-2421
Novel platinum(II) square planar coordination complexes, in which two heteroaromatic ligands are held by the metal in an unusual L-shaped geometry orthogonal to each other, have been synthesized, and their interaction with DNA was investigated with absorption and linear dichroism spectroscopy. As a rule, the ligand that is coplanar with the coordination square of Pt is found to be oriented perpendicular relative to the DNA helix axis when bound, suggestive of its intercalation between the base pairs of DNA. However, when this coplanar ligand is replaced by two pyridines, the opposite ligand, orthogonal to the coordination square, is instead preferentially intercalated. This behavior shows that these new complexes do indeed show some properties of true ambintercalators, i.e., compounds that can bind by intercalation of either of two distinct aromatic moieties. 相似文献
96.
Ammazzalorso A Amoroso R Bettoni G Chiarini M De Filippis B Fantacuzzi M Giampietro L Maccallini C Tricca ML 《Journal of chromatography. A》2005,1088(1-2):110-120
The enantiomeric separation of gemfibrozil chiral analogues was performed by capillary zone electrophoresis (CZE). Resolution of the enantiomers was achieved using heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (TM-beta-CD) as chiral selector dissolved into a buffer solution. In order to optimize the separation conditions, type, pH and concentration of running buffer and chiral selector concentration were varied. For each pH value, the optimum chiral selector concentration that produced the resolution of the isomers was found. The migration order of labile diastereoisomers formed was valued at the optimum experimental conditions by adding a pure optical isomer to the racemic mixture. Data from 1H NMR studies confirmed host-guest interaction between TM-beta-CD and 5-(2,5-dimethylphenoxy)-2-ethylpentanoic acid sodium salt. The hypothesized stoichiometry host:guest was 1:1. An apparent equilibrium constant (Ka) was estimated monitoring the chemical shift variation as a function of TM-beta-CD concentration. Salt effect on complexation equilibrium constant was also investigated. 相似文献
97.
Marina Patriarca Ferdinando Chiodo Marco Castelli Federica Corsetti Antonio Menditto 《Microchemical Journal》2005,79(1-2):337
The Me.Tos. Project, started in 1983 and still running, is an external quality assessment (EQA) scheme for laboratories performing specialized analyses in occupational and environmental laboratory medicine. Besides the organization of EQA exercises, initiatives for further education of the participants and the harmonization of EQA procedures at a European level are carried out. Participation in EQA schemes allows laboratories to comply with the international standards for the quality and competence of testing and clinical laboratories. The organization of the scheme includes the preparation of control materials, their distribution to the participants, according to strategies aimed to avoid identification of the samples, the statistical analysis of the results and the evaluation of laboratories' performance according to international guidelines and criteria set by the organizers. An overview of the scheme operation and the current performances of participants will be given. 相似文献
98.
Marina Patriarca Ferdinando Chiodo Marco Castelli Antonio Menditto 《Accreditation and quality assurance》2006,11(8-9):474-480
The results obtained by a laboratory over a number of proficiency testing/external quality assessment schemes (PT/EQAS) rounds can give information on the uncertainty of its measurements for a given test, provided that conditions such as full coverage of the routine analytical range, traceability, and small uncertainty of the assigned values (compared to the spread of the results) are met and provided that systematic deviations and any other sources of uncertainty are considered. As organisers of the Italian EQAS (ITEQAS) in occupational and environmental laboratory medicine, we tested this hypothesis using as model data from well-performing laboratories taking part in ITEQAS for lead in blood over the last 2 years. We also investigated how different PT/EQAS features (frequency of trials and number of samples) would affect a laboratory estimate of its uncertainty. Such information can be helpful in improving PT/EQAS organisation and define, for a given test: (a) the state of the art of the uncertainty of current measurement procedures, (b) identify needs for improvement of analytical methodologies and (c) set targets for acceptable uncertainty values.Presented at the Eurachem PT Workshop September 2005, Portorož, Slovenia.Papers published in this section do not necessarily reflect the opinion of the Editors, the Editorial Board and the Publisher. 相似文献
99.
Manca ML Loy G Zaru M Fadda AM Antimisiaris SG 《Colloids and surfaces. B, Biointerfaces》2008,67(2):166-170
Recently three groups of rifampicin (RIF)-loaded microparticles (MPs), consisting of chitosan (CHT), PLGA and PLGA/CHT mixtures, were assessed in terms of RIF-loading and retention during nebulisation. The CHT-coated PLGA MPs were found to exhibit high RIF-loading ability together with nebulisation ability, stability, and mucoadhesive properties. All MP types had comparable toxicity towards alveolar cells which was significantly lower than that of the free drug. Herein, we study the release of RIF from all MP-types, during incubation in buffer with pH values: 4.40 and 7.40. Results show that CHT particles exhibit a higher burst release compared to PLGA MPs; at pH 4.40, which is explained by the higher solubility of CHT in acidic media. At pH 7.40 burst release from CHT MP's is significantly lower when CHT is crosslinked with glutaraldehyde, which is consistent with their - previously observed - increased stability during nebulization. From PLGA MPs, RIF release was pH independent under the conditions applied, while the amount of PVA (stabilizer) considerably affected drug release. When PLGA MP's were coated with CHT, at pH 7.40 the retention of RIF increased further (compared to non-coated MPs), while at pH 4.40 the release was faster from the CHT-coated particles. Concluding, it is proven that when PLGA MPs are coated with CHT, in addition to increased particle mucoadhesive properties, the release kinetics of RIF are modified. 相似文献
100.
Allevi P Femia EA Costa ML Cazzola R Anastasia M 《Journal of chromatography. A》2008,1212(1-2):98-105
The present report describes a method for the quantification of N-acetyl- and N-glycolylneuraminic acids without any derivatization, using their (13)C(3)-isotopologues as internal standards and a C(18) reversed-phase column modified by decylboronic acid which allows for the first time a complete chromatographic separation between the two analytes. The method is based on high-performance liquid chromatographic coupled with electrospray ion-trap mass spectrometry. The limit of quantification of the method is 0.1mg/L (2.0ng on column) for both analytes. The calibration curves are linear for both sialic acids over the range of 0.1-80mg/L (2.0-1600ng on column) with a correlation coefficient greater than 0.997. The proposed method was applied to the quantitative determination of sialic acids released from fetuin as a model of glycoproteins. 相似文献