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131.
F. Hegelund R. Wugt Larsen R.A. Aitken K.M. Aitken M.H. Palmer 《Journal of Molecular Spectroscopy》2007,246(2):198-212
The Fourier transform infrared spectrum of gaseous 1,3,4-oxadiazole, C2H2N2O, has been recorded in the 800–1600 cm−1 wavenumber region with a resolution around 0.0030 cm−1. The four fundamental bands ν9(B1; 852.5 cm−1), ν14(B2; 1078.5 cm−1), ν4(A1; 1092.6 cm−1), and ν2(A1; 1534.9 cm−1) are analyzed by the standard Watson model. Ground state rotational and quartic centrifugal distortion constants are obtained from a simultaneous fit of ground state combination differences from three of these bands and previous microwave transitions. Upper state spectroscopic constants are obtained for all four bands from single band fits using the Watson model. The ν4 and ν14 bands form a c-Coriolis interacting dyad, and the two bands are analyzed simultaneously by a model including first and second order Coriolis resonance using the ab initio predicted Coriolis coupling constant . An extended local resonance in ν2 is explained as higher order b-Coriolis type resonance with ν6 + ν10, which is further perturbed globally by the ν15 + ν10 level. A fit of selected low-J transitions to a triad model including ν2(A1), ν6 + ν10(B1), and ν15 + ν10(A2) using an ab initio calculated Coriolis coupling constant is performed.The rotational constants, ground state quartic centrifugal distortion constants, anharmonic frequencies, and vibration–rotational constants (α-constants) predicted by quantum chemical calculations using a cc-pVTZ and TZ2P basis with B3LYP methodology, are compared with the present experimental data, where there is generally good agreement. A complete set of anharmonic frequencies and α-constants for all fundamental levels of the molecule is given. 相似文献
132.
S. Shoop R. Affleck C. Collins G. Larsen L. Barna P. Sullivan 《Journal of Terramechanics》2005,42(3-4):281-303
Tactical mobility analysis techniques were merged with land management strategies to assess potential impacts of vehicle operations on training areas for rangeland planning and management. A vehicle mobility analysis was performed for a suite of vehicle types using the NATO Reference Mobility Model (NRMM II). Input parameters include terrain information (soil type, slope, vegetation, surface roughness, soil strength), terrain surface condition based on climate (terrain strength, freeze–thaw, moisture content, snow cover), and vehicle specifications (tire, power train, weight on each axle, ground clearance, dimensions, ride). The vehicle performance was spatially mapped over the terrain for different seasons of the year and used to calculate the maneuverable acreage, which was compared to acreage needed for training requirements. This can be related to land capability based on expected training impact (Maneuver Impact Miles, MIM) and Land Condition Curves which link training density to land condition. This methodology can be used to determine the suitability of training lands and the degree of land management or rehabilitation expected. The methodology was applied to the transformation of the Alaska training lands to support a new brigade unit called the Stryker Brigade Combat Team (SBCT3), but is equally useful for other training areas and military units. For summer use, Alaska training lands are capable of supporting four times the projected training requirements. For winter, when the ground is frozen, more than 10 times the area needed was available. 相似文献
133.
134.
Regan J. Anderson Benjamin J. Compton Ching-wen Tang Astrid Authier-Hall Colin M. Hayman Gene W. Swinerd Renata Kowalczyk Paul Harris Margaret A. Brimble David S. Larsen Olivier Gasser Robert Weinkove Ian F. Hermans Gavin F. Painter 《Chemical science》2015,6(9):5120-5127
It is known that T cells can eliminate tumour cells through recognition of unique or aberrantly expressed antigens presented as peptide epitopes by major histocompatibility complex (MHC) molecules on the tumour cell surface. With recent advances in defining tumour-associated antigens, it should now be possible to devise therapeutic vaccines that expand specific populations of anti-tumour T cells. However there remains a need to develop simpler efficacious synthetic vaccines that possess clinical utility. We present here the synthesis and analysis of vaccines based on conjugation of MHC-binding peptide epitopes to α-galactosylceramide, a glycolipid presented by the nonpolymorphic antigen-presenting molecule CD1d to provoke the stimulatory activity of type I natural killer T (NKT) cells. The chemical design incorporates an enzymatically cleavable linker that effects controlled release of the active components in vivo. Chemical and biological analysis of different linkages with different enzymatic targets enabled selection of a synthetic vaccine construct with potent therapeutic anti-tumour activity in mice, and marked in vitro activity in human blood. 相似文献
135.
A technique is described for measuring the mean velocity gradient (rate-of-displacement) tensor by using a conventional stereoscopic particle image velocimetry (SPIV) system. Planar measurement of the mean vorticity vector, rate-of-rotation and rate-of-strain tensors and the production of turbulent kinetic energy can be accomplished. Parameters of the Q criterion and negative λ2 techniques used for vortex identification can be evaluated in the mean flow field. Experimental data obtained for a circular turbulent jet issuing normal to a crossflow in a low speed wind tunnel for a jet-to-crossflow velocity ratio of 3.3 are presented to show the applicability of the proposed technique. The results reveal the presence of a secondary counter-rotating vortex pair (SCVP) which is located within the jet core and has a sense of rotation opposite to that of the primary one (PCVP). Consistency of the measurements is verified by the agreement of data obtained in two perpendicular planes. Accuracy of the data is discussed and algebraic relations for some measurement uncertainties are presented. 相似文献
136.
Larsen TR Bache N Gramsbergen JB Roepstorff P 《Journal of the American Society for Mass Spectrometry》2011,22(6):989-996
Protein nitration take place on tyrosine residues under oxidative stress conditions and may influence a number of processes
including enzyme activity, protein-protein interactions and phospho-tyrosine signalling pathways. Nitrated proteins have been
identified in a number of diseases, however, the study of these proteins has been compromised by the lack of good methods
for identifying nitrated proteins, their nitration sites and the level of nitration. Here, we present a method for identification
of nitrated peptides that allows the site specific assignment of nitration, is easy to use and reproducible, and opens up
for the possibility to quantify the level of nitration of specific peptides as function of different oxidative conditions,
namely combined fractional diagonal chromatography (COFRADIC) in combination with off-line nano-LC-MALDI. We identify six
nitrated peptides from in vitro nitrated bovine serum albumin and propose that automated COFRADIC using nano-LC and off-line MALDI-MS might be a possibility
for identification of tyrosine nitrated proteins and the nitration sites in complex samples. 相似文献
137.
A convenient synthesis of 4'-aminopantetheine from commercial D-pantethine is reported. The amino group was introduced by reductive amination in order to avoid substitution at a sterically congested position. Derivatives of 4'-aminopantetheine were also prepared to evaluate the effect of O-to-N substitution on inhibitors of the resistance-causing enzyme aminoglycoside N-6'-acetyltransferase. The biological results combined with docking studies indicate that in spite of its reported unusual flexibility and ability to adopt different folds, this enzyme is highly specific for AcCoA. 相似文献
138.
Feltham HL Klöwer F Cameron SA Larsen DS Lan Y Tropiano M Faulkner S Powell AK Brooker S 《Dalton transactions (Cambridge, England : 2003)》2011,40(43):11425-11432
A family of thirteen tetranuclear heterometallic zinc(II)-lanthanide(III) complexes of the hexa-imine macrocycle (L(Pr))(6-), with general formula Zn(II)(3)Ln(III)(L(Pr))(NO(3))(3)·xsolvents (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm or Yb), were prepared in a one-pot synthesis using a 3:1:3:3 reaction of zinc(II) acetate, the appropriate lanthanide(III) nitrate, the dialdehyde 1,4-diformyl-2,3-dihydroxybenzene (H(2)L(1)) and 1,3-diaminopropane. A hexanuclear homometallic zinc(II) macrocyclic complex [Zn(6)(L(Pr))(OAc)(5)(OH)(H(2)O)]·3H(2)O was obtained using a 2:0:1:1 ratio of the same reagents. A control experiment using a 1:0:1:1 ratio failed to generate the lanthanide-free [Zn(3)(L(Pr))] macrocyclic complex. The reaction of H(2)L(1) and zinc(II) acetate in a 1:1 ratio yielded the pentanuclear homometallic complex of the dialdehyde H(2)L(1), [Zn(5)(L(1))(5)(H(2)O)(6)]·3H(2)O. An X-ray crystal structure determination revealed [Zn(3)(II)Pr(III)(L(Pr))(NO(3))(2)(DMF)(3)](NO(3))·0.9DMF has the large ten-coordinate lanthanide(III) ion bound in the central O(6) site with two bidentate nitrate anions completing the O(10) coordination sphere. The three square pyramidal zinc(II) ions are in the outer N(2)O(2) sites with a fifth donor from DMF. Measurement of the magnetic properties of [Zn(II)(3)Dy(III)(L(Pr))(NO(3))(3)(MeOH)(3)]·4H(2)O with a weak external dc field showed that it has a frequency-dependent out-of-phase component of ac susceptibility, indicative of slow relaxation of the magnetization (SMM behaviour). Likewise, the Er and Yb analogues are field-induced SMMs; the latter is only the second example of a Yb-based SMM. The neodymium, ytterbium and erbium complexes are luminescent in the solid phase, but only the ytterbium and neodymium complexes show strong lanthanide-centred luminescence in DMF solution. 相似文献
139.
140.
X-ray diffraction data of high quality measured to high resolution on crystals of the two pentitol epimers ribitol (centric) and xylitol (acentric) at 101, 141, and 181 K and data on the two compounds previously recorded at 122 K have formed the basis for multipole refinements with the VALRAY system. Our analysis showed that it is possible to obtain a reliable crystal electron density for an acentric compound (xylitol) from X-ray diffraction data and that the thermal motion can be deconvoluted from the static density in this temperature range. The Bader-type topological analysis of the static electron densities revealed virtually identical intramolecular interactions as well as very similar hydrogen bond interactions of ribitol and xylitol; the only minor differences are found in the weaker intermolecular interactions. The high-level periodic DFT calculations are in accordance with the thermodynamic measurements that show that the two pentitols have identical sublimation energies. A rigid body normal coordinate analysis was performed on the atomic displacement parameters obtained at the four different temperatures. The translational and librational mean square deviations derived through this analysis were used in a quantum statistical approach to derive frequencies of the corresponding harmonic oscillators. The analysis showed a consistent vibrational model for all temperatures. The frequencies were subsequently used to calculate crystal entropies assuming an Einstein-type behavior. These calculations show that the crystal entropy of ribitol is 8 J K(-1) mol(-1) higher than the crystal entropy of xylitol, confirming that it is a difference in the entropy of the two compounds that causes the difference in their free energy. Our results presented in this Article show the potential to use X-ray diffraction data to obtain physicochemical properties of crystals. 相似文献