Synthesis of New Flavanone Derivatives of Farrerol and Preliminary SAR Studies on Anti-VSMCs Vegetation Activity

A series of new flavanone derivatives of farrerol was designed and synthesized as a potent inhibitor of vascular smooth muscle cells(VSMCs) vegetation according to a convenient method. The structures of all the synthesized compounds were confirmed by 1H NMR, 13C NMR and EIHR-MS. The biological activities of these compounds against VSMCs in vitro were evaluated. The assay results indicate that two compounds, 5,7-dihydroxy-6,8-dimethyl- 2-(2-nitrophenyl)chroman-4-one(7f) and 2,3-dibromo-4,5-dihydroxydiphenylm...     

猪肉中二甲胺四环素的反相-高效液相色谱测定

建立了一种测定猪肉中二甲胺四环素的反相-高效液相色谱(RP-HPLC)分析方法.目标物经EDTA-Mcllvaine提取,用Oasis HLB固相萃取小柱净化,流动相为甲醇-咪唑缓冲溶液,体积比20:80,荧光检测器检测,外标法定量.平均添加回收率在89.6％～94.0％之间,相对标准偏差(RSD)在3.1％～6.5％...     

核壳结构聚丙烯酸酯抗冲改性剂的合成及粒径控制

采用预乳化多步种子乳液聚合法合成聚丙烯酸酯类聚合物(ACR)胶乳,实验得出种子乳液用量与聚丙烯酸丁酯粒径之间的关系,实现对胶乳粒子粒径的控制;对反应中影响粒子粒径的因素做了分析,以此确定最佳反应条件为:温度为65℃;乳化剂:十二烷基硫酸钠和聚氧乙烯基醚硫酸钠摩尔比为4/3,乳化剂用量为0.9％,单体固含量30％～37％...     

[Cu(Phen)(5-Fu)2](NO3)2配合物与牛血清白蛋白相互作用的荧光光谱研究

以Cu(Ⅱ)作为中心离子,5-氟脲嘧啶(5-Fu)和邻菲咯啉(Phen)作为配体,合成了[Cu(Phen)(5-Fu)2](NO3)2配合物;利用元素分析和红外光谱分析了配合物的组成和化学结构;利用荧光光谱考察了其与牛血清白蛋白(BSA)的相互作用.结果表明.配合物与BSA作用可导致BSA内源荧光猝灭;其猝灭机理为静态...     

Global Existence of the Equilibrium Diffusion Model in Radiative Hydrodynamics

This paper is devoted to the analysis of the Cauchy problem for a system of PDEs arising in radiative hydrodynamics. This system, which comes from the so-called equilibrium diffusion regime, is a variant of the usual Euler equations, where the energy and pressure functionals are modified to take into account the effect of radiation and the energy balance containing a nonlinear diffusion term acting on the temperature. The problem is studied in the multi-dimensional framework. The authors identify the existence of a strictly convex entropy and a stability property of the system, and check that the Kawashima-Shizuta condition holds. Then, based on these structure properties, the well-posedness close to a constant state can be proved by using fine energy estimates. The asymptotic decay of the solutions are also investigated.     

非线性不等式组的光滑近似方法及其收敛性

将非线性不等式组的求解转化成非线性最小二乘问题,利用引入的光滑辅助函数,构造新的极小化问题来逐次逼近最小二乘问题.在一定的条件下,文中所提出的光滑高斯-牛顿算法的全局收敛性得到保证.适当条件下,算法的局部二阶收敛性得到了证明.文后的数值试验表明本文算法有效.     

模范畴Recollement的Koenig定理

Koenig定理描述了环的导出范畴允许recollement的一个充分必要条件.本文给出环的模范畴版本的Koenig定理及其应用.应用一是可以导出Morita等价定理,应用二是可以描述三角矩阵环与模范畴的recollement之间的密切联系.     

关于一个脉冲用药的HIV免疫模型的研究

对一个脉冲用药的HIV免疫模型进行研究,发现在用药间隔足够小时,预防抗化剂的脉冲使用通过使T细胞水平无限接近于未被感染的免疫水平来保持个体的免疫功能,并且文中进一步给出这个合适的用药间隔估计.这对指导AIDS治疗临床实践具有参考意义.     

佩尔方程的最小正整数解

用C语言编写程序,解决了d是10000以内的非平方数,佩尔方程x~2-dy~2=±1的最小正整数解的计算问题.     

一个海洋噬菌体感染模型的分析

对一个海洋病毒感染模型进行研究,分析其动力学行为,研究系统平衡点的存在性,稳定性及分支的产生.这对海洋生态研究具有一定意义.