Near-Infrared BODIPY-Acridine Dyads Acting as Heavy-Atom-Free Dual-Functioning Photosensitizers

Boron dipyrromethene (BODIPY) dyes represent a particular class within the broad array of potential photosensitizers. Their highly fluorescent nature opens the door for theragnostic applications, combining imaging and therapy using a single, easily synthesized chromophore. However, near-infrared absorption is strongly desired for photodynamic therapy to enhance tissue penetration. Furthermore, singlet oxygen should preferentially be generated without the incorporation of heavy atoms, as these often require additional synthetic efforts and/or afford dark cytotoxicity. Solutions for both problems are known, but have never been successfully combined in one simple BODIPY material. Here, we present a series of compact BODIPY-acridine dyads, active in the phototherapeutic window and showing balanced brightness and phototoxic power. Although the donor–acceptor design was envisioned to introduce a charge transfer state to assist in intersystem crossing, quantum-chemical calculations refute this. Further photophysical investigations suggest the presence of exciplex states and their involvement in singlet oxygen formation.     

Enhanced Second-Harmonic Generation with Structured Light in AlGaAs Nanoparticles Governed by Magnetic Response

JETP Letters - We employ structured light for the second-harmonic generation from subwavelength AlGaAs nanoparticles that support both electric and magnetic multipolar Mie resonances. The vectorial...     

Influence of external loading on the stability of a fluid-conveying pipeline

A section of a fluid-conveying pipeline is analyzed for stability. The section is modeled by an elastic cylindrical shell of finite length under external static loading. Two qualitatively different instability modes are studied: “quasistatic” (divergence) and dynamic (flutter). The effect of uniform radial pressure and uniform axial pressure on the instability modes is analyzed     

Photorefractive light scattering in lithium niobate crystals doped with Mg2+, B3+, Y3+, and Ta5+

We have investigated the photorefractive (photoinduced) light scattering in lithium niobate single crystals: LiNbO₃, LiNbO₃:B, LiNbO₃:Y(0.46 mas %), LiNbO₃:Y(0.24):Mg(0.63 mas %), and LiNbO₃:Ta(1.13):Mg(0.0109 mas %) that were grown from congruent melts. We have found that the shape of the speckle structure of this scattering and the kinetics of the development of its indicatrix depend substantially on the type of the impurity dopant in the lithium niobate crystal. We have observed that, upon laser irradiation of crystals doped with Y³⁺, Ta⁵⁺:Mg²⁺, and Y³⁺:Mg²⁺, the shape of their scattering indicatrix changes with time. At the same time, the LiNbO₃:B crystal is characterized by a complete absence of time changes in its speckle structure, which indicates that the photorefractive effect in this crystal is substantially lowered.     

Joint analysis of ESR lineshapes and 1H NMRD profiles of DOTA-Gd derivatives by means of the slow motion theory

The "Swedish slow motion theory" [Nilsson and Kowalewski, J. Magn. Reson. 146, 345 (2000)] applied so far to Nuclear Magnetic Relaxation Dispersion (NMRD) profiles for solutions of transition metal ion complexes has been extended to ESR spectral analysis, including in addition g-tensor anisotropy effects. The extended theory has been applied to interpret in a consistent way (within one set of parameters) NMRD profiles and ESR spectra at 95 and 237 GHz for two Gd(III) complexes denoted as P760 and P792 (hydrophilic derivatives of DOTA-Gd, with molecular masses of 5.6 and 6.5 kDa, respectively). The goal is to verify the applicability of the commonly used pseudorotational model of the transient zero field splitting (ZFS). According to this model the transient ZFS is described by a tensor of a constant amplitude, defined in its own principal axes system, which changes its orientation with respect to the laboratory frame according to the isotropic diffusion equation with a characteristic time constant (correlation time) reflecting the time scale of the distortional motion. This unified interpretation of the ESR and NMRD leads to reasonable agreement with the experimental data, indicating that the pseudorotational model indeed captures the essential features of the electron spin dynamics.     

Spectral and Luminescent Properties of 21-Thia-5,10,15,20-Tetra-(4-Sulfonatophenyl)Porphyrin: Role of Heterosubstitution and Halochroism

Journal of Applied Spectroscopy - The spectral and luminescent properties of hydrophilic 21-thia-5,10,15,20-tetra(4-sulfonatophenyl)porphyrin and 5,10,15,20-tetra(4-sulfonatophenyl)porphyrin in...     

Wiener integrals, Malliavin calculus and covariance measure structure

We introduce the notion of covariance measure structure for square integrable stochastic processes. We define Wiener integral, we develop a suitable formalism for stochastic calculus of variations and we make Gaussian assumptions only when necessary. Our main examples are finite quadratic variation processes with stationary increments and the bifractional Brownian motion.