Extracting γ and penguin topologies through CP violation in B_{s}^{0}\to J/\psi K_{\mathrm{S}}

The $B_{s}^{0}\to J/\psi K_{\mathrm{S}}$ decay has recently been observed by the CDF collaboration and will be of interest for the LHCb experiment. This channel will offer a new tool to extract the angle γ of the unitarity triangle and to control doubly Cabibbo-suppressed penguin corrections to the determination of sin?2β from the well-known $B_{d}^{0}\to J/\psi K_{\mathrm{S}}$ mode with the help of the U-spin symmetry of strong interactions. While any competitive determination of γ is interesting, the latter aspect is particularly relevant as LHCb will enter a territory of precision which makes the control of doubly Cabibbo-suppressed Standard-Model corrections mandatory. Using the data from CDF and the e ⁺ e ^? B factories as a guideline, we explore the sensitivity for γ and the penguin parameters and point out that the $B_{s}^{0}$ – $\bar{B}_{s}^{0}$ mixing phase φ _s , which is only about ?2° in the Standard Model but may be enhanced through new physics, is a key parameter for these analyses. We find that the mixing-induced CP violation $S(B_{s}^{0}\to J/\psi K_{\mathrm{S}})$ shows an interesting correlation with sin?φ _s , which serves as a target region for the first measurement of this observable at LHCb.     

A Proposal for a Low-Frequency Axion Search in the 1–2 μ eV Range and Below with the BabyIAXO Magnet

In the near future BabyIAXO will be the most powerful axion helioscope, relying on a custom-made magnet of two bores of 70 cm diameter and 10 m long, with a total available magnetic volume of more than 7 m³. In this document, it proposes and describe the implementation of low-frequency axion haloscope setups suitable for operation inside the BabyIAXO magnet. The RADES proposal has a potential sensitivity to the axion-photon coupling down to values corresponding to the KSVZ model, in the (currently unexplored) mass range between 1 and 2 eV, after a total effective exposure of 440 days. This mass range is covered by the use of four differently dimensioned 5-meter-long cavities, equipped with a tuning mechanism based on inner turning plates. A setup like the one proposed will also allow an exploration of the same mass range for hidden photons coupled to photons. An additional complementary apparatus is proposed using LC circuits and exploring the low energy range ( eV). The setup includes a cryostat and cooling system to cool down the BabyIAXO bore down to about 5 K, as well as an appropriate low-noise signal amplification and detection chain.     

Preparation of 4′-Spirocyclobutyl Nucleoside Analogues as Novel and Versatile Adenosine Scaffolds

Despite the large variety of modified nucleosides that have been reported, the preparation of constrained 4′-spirocyclic adenosine analogues has received very little attention. We discovered that the [2+2]-cycloaddition of dichloroketene on readily available 4′-exo-methylene furanose sugars efficiently results in the diastereoselective formation of novel 4′-spirocyclobutanones. The reaction mechanism was investigated via density functional theory (DFT) and found to proceed either via a non-synchronous or stepwise reaction sequence, controlled by the stereochemistry at the 3′-position of the sugar substrate. The obtained dichlorocyclobutanones were converted into nucleoside analogues, providing access to a novel class of chiral 4′-spirocyclobutyl adenosine mimetics in eight steps from commercially available sugars. Assessment of the biological activity of designed 4′-spirocyclic adenosine analogues identified potent inhibitors for protein methyltransferase target PRMT5.     

Simple Synthetic Routes to N-Heterocyclic Carbene Gold(I)–Aryl Complexes: Expanded Scope and Reactivity

The discovery of sustainable and scalable synthetic protocols leading to gold–aryl compounds bearing N-heterocyclic carbene (NHC) ligands sparked an investigation of their reactivity and potential utility as organometallic synthons. The use of a mild base and green solvents provide access to these compounds, starting from widely available boronic acids and various [Au(NHC)Cl] complexes, with reactions taking place under air, at room temperature and leading to high yields with unprecedented ease. One compound, (N,N′-bis[2,6-(di-isopropyl)phenyl]imidazol-2-ylidene)(4-methoxyphenyl)gold, ([Au(IPr)(4-MeOC₆H₄)]), was synthesized on a multigram scale and used to gauge the reactivity of this class of compounds towards C−H/N−H bonds and with various acids, revealing simple pathways to gold–based species that possess attractive properties as materials, reagents and/or catalysts.     

Influence of viscoelasticity on drop deformation and orientation in shear flow: Part 1. Stationary states

The influence of matrix and droplet viscoelasticity on the steady deformation and orientation of a single droplet subjected to simple shear is investigated microscopically. Experimental data are obtained in the velocity–vorticity and velocity–velocity gradient plane. A constant viscosity Boger fluid is used, as well as a shear-thinning viscoelastic fluid. These materials are described by means of an Oldroyd-B, Giesekus, Ellis, or multi-mode Giesekus constitutive equation. The drop-to-matrix viscosity ratio is 1.5. The numerical simulations in 3D are performed with a volume-of-fluid algorithm and focus on capillary numbers 0.15 and 0.35. In the case of a viscoelastic matrix, viscoelastic stress fields, computed at varying Deborah numbers, show maxima slightly above the drop tip at the back and below the tip at the front. At both capillary numbers, the simulations with the Oldroyd-B constitutive equation predict the experimentally observed phenomena that matrix viscoelasticity significantly suppresses droplet deformation and promotes droplet orientation. These two effects saturate experimentally at high Deborah numbers. Experimentally, the high Deborah numbers are achieved by decreasing the droplet radius with other parameters unchanged. At the higher capillary and Deborah numbers, the use of the Giesekus model with a small amount of shear-thinning dampens the stationary state deformation slightly and increases the angle of orientation. Droplet viscoelasticity on the other hand hardly affects the steady droplet deformation and orientation, both experimentally and numerically, even at moderate to high capillary and Deborah numbers.     

Designing performance incentives, an international benchmark study in the water sector

Cross-country comparisons avoid the unsteady equilibrium in which regulators have to balance between economies of scale and a sufficient number of remaining comparable utilities. By the use of data envelopment analysis, we compare the efficiency of the drinking water sector in the Netherlands, England and Wales, Australia, Portugal and Belgium. After introducing a procedure to measure the homogeneity of an industry, robust order-m partial frontiers are used to detect outlying observations. By applying bootstrapping algorithms, bias-corrected first and second stage results are estimated. Our results suggest that incentive regulation in the sense of regulatory and benchmark incentive schemes have a significant positive effect on efficiency. By suitably adapting the conditional efficiency measures of Daraio and Simar (Advanced robust and nonparametric methods in efficiency analysis. Springer, New York 2007) to the bias corrected estimates of Simar and Wilson (Manage Sci, 44(1): 49–61, 1998), we incorporate environmental variables directly into the efficiency estimates. We firstly equalize the social, physical and institutional environment, and secondly, deduce the effect of incentive schemes on utilities as they would work under similar conditions. The analysis demonstrates that in absence of clear and structural incentives the average efficiency of the utilities falls in comparison with utilities which are encouraged by incentives.     

Influential observations in frontier models,a robust non-oriented approach to the water sector

This paper suggests an outlier detection procedure which applies a nonparametric model accounting for undesired outputs and exogenous influences in the sample. Although efficiency is estimated in a deterministic frontier approach, each potential outlier initially benefits of the doubt of not being an outlier. We survey several outlier detection procedures and select five complementary methodologies which, taken together, are able to detect all influential observations. To exploit the singularity of the leverage and the peer count, the super-efficiency and the order-m method and the peer index, it is proposed to select these observations as outliers which are simultaneously revealed as atypical by at least two of the procedures. A simulated example demonstrates the usefulness of this approach. The model is applied to the Portuguese drinking water sector, for which we have an unusually rich data set.