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331.
Anna Brodzka Pawe Kowalczyk Damian Trzepizur Dominik Koszelewski Karol Kramkowski Mateusz Szymczak Aleksandra Wypych Rafa Lizut Ryszard Ostaszewski 《Molecules (Basel, Switzerland)》2022,27(20)
The impact of substituent at phenyl ring of diethyl benzylphosphonate derivatives on cytotoxic activity was studied. The organophosphonates were obtained based on developed palladium-catalyzed α, β-homodiarylation of vinyl esters protocol. The new synthetic pathway toward 1,2-bis(4-((diethoxyphosphoryl)methyl)phenyl)ethyl acetate was proposed which significantly improves the overall yield of the final product (from 1% to 38%). Several newly synthesized organophosphonates were tested as new potential antimicrobial drugs on model Escherichia coli bacterial strains (K12 and R2-R3). All tested compounds show the highest selectivity and activity against K12 and R2 strains. Preliminary cellular studies using MIC and MBC tests and digestion of Fpg after modification of bacterial DNA suggest that selected benzylphosphonate derivatives may have greater potential as antibacterial agents than typically used antibiotics such as ciprofloxacin, bleomycin and cloxacillin. These compounds are highly specific for pathogenic E. coli strains based on the model strains used and may be engaged in the future as new substitutes for commonly used antibiotics, which is especially important due to the increasing resistance of bacteria to various drugs and antibiotics. 相似文献
332.
Kowalczyk P Gauden PA Terzyk AP Bhatia SK 《Langmuir : the ACS journal of surfaces and colloids》2007,23(7):3666-3672
Hydrogen in slit-like carbon nanopores at 77 K represents a quantum fluid in strong confinement. We have used path-integral grand canonical Monte Carlo and classical grand canonical Monte Carlo simulations for the investigation of the "quantumness" of hydrogen at 77 K adsorbed in slit-like carbon nanopores up to 1 MPa. We find that classical simulations overpredict the hydrogen uptake in carbon nanopores due to neglect of the quantum delocalization. Such disagreement of both simulation methods depends on the slit-like carbon pore size. However, the differences between the final uptakes of hydrogen computed from both classical and quantum simulations are not large due to a similar effective size of quantum/classical hydrogen molecules in carbon nanospaces. For both types of molecular simulations, the volumetric density of stored energy in optimal carbon nanopores exceeds 6.4 MJ dm(-3) (i.e., 45 kg m(-3); Department of Energy target for 2010). In contrast to the hydrogen adsorption isotherms, we found a large reduction of isosteric enthalpy of adsorption computed from the quantum Feynman's path-integral simulations in comparison to the classical values at 77 K and pressures up to 1 MPa. Depression of the quantum isosteric enthalpy of adsorption depends on the slit-like carbon pore size. For the narrow pores (pore width H in [0.59-0.7] nm), the reduction of the quantum isosteric enthalpy of adsorption at zero coverage is around 50% in comparison to the classical one. We observed new phenomena called, by us, the quantum confinement-inducing polymer shrinking. In carbon nanospaces, the quantum cyclic polymers shrink, in comparison to its bulk-phase counterpart, due to a strong confinement effect. At considered storage conditions, this complex phenomenon depends on the size of the slit-like carbon nanopore and the density of hydrogen volumetric energy. For the smallest nanopores and a low density of hydrogen volumetric energy, the reduction of the polymer effective size is the highest, whereas an increase of the pore size and the density of hydrogen volumetric energy causes the polymer swelling up to a value slightly below the one computed from the bulk phase. Quantum confinement-inducing polymer shrinking is of great importance for realizing the potential of quantum molecular sieves. 相似文献
333.
I. Sankowska Ch. Droste E. Grodner T. Morek J. Srebrny A. A. Pasternak J. Kownacki P. Napiorkowski S. G. Rohoziński M. Kowalczyk M. Kisieliński R. Kaczarowski E. Ruchowska 《The European Physical Journal A - Hadrons and Nuclei》2008,37(2):169-175
Lifetimes of the yrast levels with spins I π = 23/2? to 39/2? in 129La produced via the 120Sn(14N, 5n) reaction at a beam energy of 77MeV have been measured by the Doppler shift attenuation method. The properties of the studied levels belonging to the πh11/2 band were compared with the theoretical predictions obtained in the framework of the core quasi-particle coupling model. It is suggested that the rigid-rotor model used to describe the cores is too simplified as the even-even nuclei from the A ~ 130 region are susceptible to shape deformation. Reasonable agreement was obtained with the phenomenological cores based on the experimental data of 128Ba. 相似文献
334.
Salami H Ross AJ Crozet P Jastrzebski W Kowalczyk P Le Roy RJ 《The Journal of chemical physics》2007,126(19):194313
Fourier transform spectra of near-infrared laser-induced fluorescence in (39)K(6)Li show transitions to high vibrational levels of both the X (1)Sigma(+) and a (3)Sigma(+) electronic states. These include 147 transitions into six vibrational levels of the a (3)Sigma(+) state, which lie between 7 and 88 cm(-1) below the dissociation asymptote. Unfortunately, their energies span less than 30% of the well depth. However, fitting those data to eigenvalues of analytical model potential functions whose outer limbs incorporate the theoretically predicted long-range form, V(R) approximately D-C(6)R(6)-C(8)R(8), yields complete, plausible potential curves for this state. The best fits converge to remarkably similar solutions which indicate that D(e)=287(+/-4) cm(-1) and R(e)=4.99(+/-0.09) A for the a (3)Sigma(+) state of KLi, with omega(e)=47.3(+/-1.4) and 44.2(+/-1.5) cm(-1) for (39)K(6)Li and (39)K(7)Li, respectively. Properties of the resulting potential are similar to those of a published ab initio potential and are consistent with those of the analogous states of Li(2), K(2), Na(2), and NaK. 相似文献
335.
Kowalczyk J Barski P Witt D Grzybowski BA 《Langmuir : the ACS journal of surfaces and colloids》2007,23(5):2318-2321
Various types of asymmetric disulfides can be synthesized under mild conditions and in excellent yields by a method involving dialkoxylthiophosphoranesulfenyl halide precursors. This straightforward, rapid procedure is used to prepare a series of disulfides bearing neutral, acidic, and basic terminal groups as well as groups commonly used in biospecific self-assembled monolayers. 相似文献
336.
Berkessel A Ertürk E Kaiser P Klein A Kowalczyk RM Sarkar B 《Dalton transactions (Cambridge, England : 2003)》2007,(31):3427-3434
Tetraarylporphyrin ruthenium complexes [Ru(L)(aryl(4)Por)] (L = CO or PF(3); aryl = mesityl or 10-R'-bis-methano-octahydroanthracene-9-yl with R' = H, CF(3), OCH(3) or CH(3)) show a rich electrochemistry with at least five different stable oxidation states (including the parent state). The overall character of the redox behaviour is porphyrin-centred. However detailed spectroelectrochemical investigations using IR, UV/Vis/NIR and EPR spectroscopy (X- and K band) gave clear indication for ruthenium contributions. 相似文献
337.
338.
Using grand canonical Monte Carlo simulation we show, for the first time, the influence of the carbon porosity and surface oxidation on the parameters of the Dubinin-Astakhov (DA) adsorption isotherm equation. We conclude that upon carbon surface oxidation, the adsorption decreases for all carbons studied. Moreover, the parameters of the DA model depend on the number of surface oxygen groups. That is why in the case of carbons containing surface polar groups, SF(6) adsorption isotherm data cannot be used for characterization of the porosity. 相似文献
339.
Ewelina Patyra Ewelina Kowalczyk Krzysztof Kwiatek 《Analytical and bioanalytical chemistry》2013,405(21):6799-6806
A chromatographic procedure for the determination of oxytetracycline (OTC), tetracycline (TC), chlorotetracycline (CTC), and doxycycline (DC) in medicated feedingstuffs was developed. Samples were extracted with 0.01 M citric buffer/acetonitrile (pH 3.0) and further purified with 0.45 μm syringe filters. The purified extract was separated on Thermo column C18, 150?×?4 mm, 5 μm and detection was carried out at 360 nm for OTC, and TC, 370 nm for CTC, and 350 nm for DC. TCs were eluted with a mobile phase of 0.03 M SDS/7 % 1-butanol/0.02 M oxalic acid/NaOH at pH 2.5. This method provided average recoveries of 80.4 % to 100.2 %, with CVs of 0.5 % to 6.6 % in the range of 50 to 1500 mg/kg OTC, TC, CTC, and DC in feeds. The linearity for the four TCs was determined by high-performance liquid chromatography-diode array detector (HPLC-DAD) in the range 10–300 μg/mL (50–1500 mg/kg), with a linear correlation coefficient (R)?>?0.99. The LOD and LOQ for TCs in pig and poultry feeds ranged from 4.0 to 10.7 and 4.7 to 12.6 mg/kg, respectively. The methodology was applied to the analysis of animal feedingstuffs collected from poultry and pig farms. Figure
Extraction procedure and chromatographic condition for the isolation TCs from animal medicated feedingstuffs 相似文献
340.
Hybridization of a Flexible Cyclooctatetraene Core and Rigid Aceneimide Wings for Multiluminescent Flapping π Systems 下载免费PDF全文
Dr. Chunxue Yuan Dr. Shohei Saito Dr. Cristopher Camacho Dr. Tim Kowalczyk Prof. Dr. Stephan Irle Prof. Dr. Shigehiro Yamaguchi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(8):2193-2200
The hybridization of flexible and rigid π‐conjugated frameworks is a potent concept for producing new functional materials. In this article, a series of multifluorescent flapping π systems that combine a flexible cyclooctatetraene (COT) core and rigid aceneimide wings with various π‐conjugation lengths has been designed and synthesized, and their structure/properties relationships have been investigated. Whereas these molecules have a V‐shaped bent conformation in the ground state, the bent structure changes to a planar conformation in the lowest excited singlet (S1) state irrespective of the lengths of the aceneimide wings. However, the fluorescence behavior in solution is distinct between the naphthaleneimide system and the anthraceneimide system. The former has a nonemissive S1 state owing to the significant contribution of the antiaromatic character of the planar COT frontier molecular orbitals, thereby resulting in complete fluorescence quenching in solution. In contrast, the latter anthraceneimide system shows an intense emission, which is ascribed to the planar but distorted S1 state that shows the allowed transition between the π‐molecular orbitals delocalized over the COT core and the acene wings. The other characteristic of these π systems is the significantly redshifted fluorescence in the crystalline state relative to their monomer fluorescence. The relationship between the packing structures and the fluorescence properties was investigated by preparing a series of hybrid π systems with different sizes of substituents on the imide moieties, which revealed the effect of the twofold π‐stacked structure of the V‐shaped molecules on the large bathochromic shift in emission. 相似文献