Isolation of γ-globulin from blood serum by chromatography on aminosilochrome C-80

Summary A method has been developed for isolating a fraction enriched in -globulin from human blood serum on a column of aminosilochrome C-80.All-Union Scientific-Research Institute of the Genetics and Breeding of Industrial Microorganisms, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 261–265, March–April, 1977.     

Depth of focus of intraocular lenses with higher-order aberrations

The optimization problem of increasing the depth of the sharply imaged space of the intraocular lens is considered depending on its phase transmission. For a set of aberrations with axial symmetry, the phase profile of the model optical system is determined, which makes it possible to obtain recognizable images of a test object placed at a distance from 5 m to 40 cm.     

Effect of acid activation on sorption of phenylalanine on clynoptilolyte tufa

The effect of acid activation on the sorption of clynoptilolyte tufa with respect to phenylalanine is investigated. The treatment of clynoptilolyte tufa with 4.0 M of hydrochloric acid is found to yield a substantial increase in sorption of the aromatic amino acid. Different types of interaction in the acid-activated clynoptilolyte tufa-water-aromatic amino acid are revealed. The effect of pH of the solution of the sorption parameter is demonstrated.     

Europium-directed self-assembly of a luminescent supramolecular gel from a tripodal terpyridine-based ligand

Eu(III), the last piece in the puzzle: Europium-induced self-assembly of ligands having a C(3)-symmetrical benzene-1,3,5-tricarboxamide core results in the formation of luminescent gels. Supramolecular polymers are formed through hydrogen bonding between the ligands. The polymers are then brought together into the gel assembly through the coordination of terpyridine ends by Eu(III) ions (blue dashed arrow: distance between two ligands in the strand direction).     

Synthesis of luminescent homo-dinuclear cationic lanthanide cyclen complexes bearing amide pendant arms through the use of copper catalysed (1,3-Huisgen, CuAAC) click chemistry

The design and synthesis of dinuclear-lanthanide complexes possessing triazole-based bridges, formed by using copper catalysed 1,3-cycloaddition reactions between heptadentate alkyne functionalised cyclen europium or terbium complexes and di-azides (CuAAC reactions), are described. While this click reaction worked well for the formation of the homo-Eu(III) and Tb(III) bis-tri-arm cyclen N,N-dimethyl acetamide complexes, 2Eu and 2Tb, and for the homo-Eu(III) chiral N-methylnaphthalene based complexes 3Eu (S,S,S) and 4Eu (R,R,R), the formation of the Eu(III) complex of the primary amide analogue of 2, namely 1Eu, was not successful, clearly demonstrating the effect that the nature of the pendant arms has on this reaction. Furthermore, the click reactions between the free alkyne cyclen bis-derivatives (5-8) and the di-azide were unsuccessful, most likely due to the high affinity of the cyclen macrocycles for Cu(II). The Eu(III) complexes of 2-4 and 2Tb all gave rise to sensitised metal ion centred emission upon excitation of the triazole or the naphthalene antennae in methanol solution, and their hydration states were determined, which showed that while the Eu(III) mono-nuclear complexes had q ～ 2, the click products all had q ～ 1. In the case of 3Eu (S,S,S) and 4Eu (R,R,R), the circular polarised emission (CPL) was also observed for both, demonstrating the chiral environment of the lanthanide centres.     

Development of novel formulations for photodynamic therapy on the basis of amphiphilic polymers and porphyrin photosensitizers. Porphyrin-polymer complexes in model photosensitized processes

We have studied the effect of amphiphilic polymers with different structure (polyvinylpyrrolidone, polyethyleneoxide and a triblock copolymer of ethylene- and propyleneoxide—(Pluronic F127)) on the photoactivity of a hematoporphyrin derivative (dimegin). It has been shown that such polymers can cause a considerable increase in the porphyrin photosensitizer (PPS) activity both in the process of singlet oxygen photogeneration and in the reaction of a substrate photooxidation in D2O and water. Among the studied polymers, polyvinylpyrrolidone appeared to have a most significant influence onto the photoactivity of dimegin. We attribute the observed effect of the amphiphilic polymers on the photoactivity of dimegin to the presence of polymer-porphyrin interactions resulting in the porphyrin disaggregation in aqueous phase. Using 1H NMR spectroscopy, we have found that dimegin binds to the polymers via the PPS interaction mainly with the hydrophobic fragments of polymeric macromolecules. However, in the case of polyvinylpyrrolidone we observed also PPS interactions with the hydrophilic fragments of macromolecules.     

Long-lived excited state of spiroanthroxazine after its matrix isolation in halogenated polyolefins by supercritical fluid impregnation

Supercritical fluid impregnation was used to perform matrix isolation of spiroanthroxazine (SAO) photochromic molecules in halogenated polymer films (polyvinylchloride and tetrafluoroethylene copolymer with vinylidene fluoride). An excited (colored) SAO form not relaxing to the ground (colorless) state was stabilized in polymers. Such a long-lived excited SAO form could exist as an isomer of the B form (B₅₃₅ with an absorption band at λ_max = 535 nm) in the fluorinated polymer matrix, for which the absorption maximum was shifted by more than 75 nm to the blue, and as the B form with a small admixture of the B₅₃₅-form (in polyvinylchloride).     

Formation of vortex light fields of specified intensity for laser micromanipulation

method for calculating phase diffractive elements is proposed to form light fields with intensity described by flat curves. This method is based on the optics of spiral light beams and Gerchberg-Saxton iterative algorithm. The experimental data on the formation of fields and their use in manipulation with latex microparticles are reported.     

Study of inclusive production of π± and protons in\bar p p interactions at 32 GeV/c

Results are presented on the inclusive production of π^± mesons and protons in \(\bar p\) p interactions at an incident antiproton momentum of 32 GeV/c in the MIRABELLE bubble chamber, based on a sample of 55,000 inelastic events. The spectra of π⁺(π^?) andp( \(\bar p\) ) are separated in the whole kinematically admitted region of phase space by a statistical method. The semi-inclusive and inclusive cross sections and the main average characteristics of π andp production are calculated. The invariant differential cross sections are studied as functions of the Fevnman scaling variablex, the rapidity and the transverse momentum. Thex distribution of π^± mesons in the proton fragmentation region does not show any significant contribution from quark exchange or annihilation processes. A possible contribution of hard quark scattering on mesons or baryons is observed for large transverse momenta.