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41.
J. I. Hall 《Combinatorica》1987,7(1):77-85
Within the Johnson schemeI(m, d) we find the graphK(m, d) ofd-subsets of anm-set, two such adjacent when disjoint. Among all connected graphs,K(m, d) is characterized by the isomorphism type of its vertex neighborhoods providedm is sufficiently large compared tod.
Partial support provided by NSF (USA), SERC (UK), ZWO (NL). 相似文献
42.
In 1987 the Canadian Department of National Defence enunciated the Total Force concept. The Total Force is comprised of Regular and Reserve components. The intention is to make maximum use of the Reserve to reduce defence expenditures and at the same time to ensure that military capability remains adequate to support national policy objectives. This paper discusses some of the governing parameters that affect the modelling of the composition of the Total Force and analyses the mix of regular and reserve forces. The interplay between the key factors and their marginal costs will be stressed. The models are employed to study two units in the Canadian Forces, a maintenance support unit and a tactical unit with high operational activity cost. The lessons drawn from these studies are highlighted. 相似文献
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Kevin J. Luebke 《Chemistry & biology》1998,5(12):R317
Genetically encoded fluorescent labels, such as green fluorescent protein, make it possible to visualize a protein's natural distribution and environment in living cells. A new approach to protein labeling in living cells has been devised in which a small, membrane-permeable ligand binds with high affinity and specificity to a short peptide motif that can be incorporated into the protein of interest; the ligand becomes brightly fluorescent after binding to the peptide. 相似文献
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48.
Carolina de Gregorio Lemont B. Kier Lowell H. Hall 《Journal of computer-aided molecular design》1998,12(6):557-561
A structure-activity analysis of a series of steroids binding to corticosteroid-binding globulin was made using the electrotopological state index for each atom in the molecule. Two indices were found to correlate well with the binding affinity. The indices encode structural characteristics in the A and the D rings of the steroids in the study. One of the indices was formulated as the difference between two indices in the A ring. The two were not intercorrelated, suggesting that the composite index signals the influence of structure changes in or near the A ring that can be monitored by the composite index. This is a new observation using this structure-activity method. It is suggested that this model makes some contributions towards detection of the pharmacophore. 相似文献
49.
Effects of flanking band proximity, number, and modulation pattern on comodulation masking release 总被引:1,自引:0,他引:1
Comodulation masking release for a 700-Hz pure-tone signal was investigated as a function of the number and spectral positions of 20-Hz-wide comodulated flanking bands. In the first experiment, all stimuli were presented diotically. CMR was examined as a function of the number of flanking bands present, in conditions where the bands were arranged symmetrically around the signal frequency, were below the signal frequency, or were above the signal frequency. The number of flanking bands ranged from one to eight, and the magnitude of the diotic CMR ranged from approximately 5-16 dB. The results indicated: (1) bands closer to the signal resulted in larger masking release, and (2) more bands gave rise to larger CMR (but with diminishing returns above two flanking bands). Two additional sets of diotic conditions were examined and compared to the condition where all eight comodulated flanking bands were present: In one set of conditions, two of the eight flanking bands were removed; in the other set of conditions, two of the eight flanking bands were replaced with bands (termed "deviant" bands) that were not comodulated with respect to the other bands. There was very little effect of reducing eight bands to six, even when the removed bands were relatively near the signal frequency; however, CMR was substantially reduced when deviant bands were introduced, particularly when the deviant bands were placed relatively near the signal frequency. These reductions in CMR were slightly greater when each of the deviant bands had a unique modulation pattern (bideviant bands) than when the two deviant bands themselves shared the same modulation pattern (codeviant bands). In the second experiment, dichotic conditions were examined where the number and spectral positions of the flanking bands in the nonsignal ear were varied (the signal ear received only a 20-Hz-wide noise band centered on the signal frequency). The magnitude of the dichotic CMR ranged from approximately 2-10 dB, depending on condition. Effects of proximity and the number of flanking bands were similar to the effects obtained in diotic conditions. For both the diotic and the dichotic data, the effects of proximity were more consistent with an interpretation based upon across-channel processing than upon a within-channel interaction. The results obtained using deviant bands indicate that it is difficult for the auditory system to disregard the modulation pattern of flanking bands that differ from the modulation pattern of the on-signal band, particularly if such bands are proximal to the signal frequency. 相似文献
50.
The detectability of a pure-tone signal masked by a band of noise centered on the signal can be improved by the addition of flanking noise bands, provided that the temporal envelopes of the flanking bands are correlated with that of the on-signal band. This phenomenon is referred to as comodulation masking release (CMR). The present study examined CMR in conditions in which some flanking noise bands were comodulated with the on-signal band, but other flanking bands (termed "deviant" bands) were not. Past research has indicated that CMR is often substantially reduced when deviant bands are present at spectral locations close to the signal frequency. An investigation was undertaken to determine whether the disruptive effects of such bands could be reduced by factors related to auditory grouping. The signal frequency was 100 Hz. In one condition, only 20-Hz-wide comodulated bands, centered on 400, 600, 800, 1000, 1200, 1400, and 1600 Hz, were present. The CMR for this condition, referenced to threshold for the on-signal band only, was approximately 15 dB. In a second condition, two deviant bands were added at 900 and 1100 Hz; their presence reduced the CMR to only 3-4 dB. The number of deviant bands was then increased progressively, from two to eight bands. Deviant bands either shared a common envelope (codeviant), or had unique envelopes (multideviant). The number of bands that were comodulated with the on-signal band was held constant at six.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献