Medicinal carbon tablets for treatment of acetaminophen intoxication: adsorption characteristics of medicinal carbon powder and its tablets

Adsorption characteristics of medicinal carbon powder (JP 14) for acetaminophen were examined at 37 degrees C using conventional incubation in an attempt to obtain an effective oral dosage form. Hydroxypropyl cellulose (HPC) and maltitol (MT), being able to act as a binding agent, were tested as additives. Tablets of medicinal carbon were produced by the wet granulation method. The rate and extent of adsorption of the medicinal carbon powder were roughly similar in water, JP 14 1st fluid (pH 1.2) and JP 14 2nd fluid (pH 6.8). The relationship between concentrations of free and adsorbed acetaminophen indicated that the adsorption followed the Langmuir mode. The maximal adsorption of acetaminophen in water was 0.219 g per gram medicinal carbon powder, little influenced by the addition of MT, but slightly reduced by the addition of HPC. The tablet prepared using MT as a binding agent displayed a favorable hardness and adequate disintegration time. The tablet showed good adsorption potential for acetaminophen, though the adsorption rate and extent of the tablet were reduced to some extent as compared with powder.     

The independence number condition for the existence of a spanning f‐tree

Let G be a graph and f be a mapping from V(G) to the positive integers. A subgraph T of G is called an f‐tree if T forms a tree and d_T(x)≤f(x) for any x∈V(T). We propose a conjecture on the existence of a spanning f‐tree, and give a partial solution to it. © 2009 Wiley Periodicals, Inc. J Graph Theory 65: 173–184, 2010     

Densities and Viscosities of Tris(acetylacetonato)cobalt(III) Complex Solutions in Various Solvents

The densities and the viscosities of tris(acetylacetonato)cobalt(III) solutions in acetonitrile, dichloromethane, chloroform, tetrachloromethane, benzene, toluene, ethylbenzene, and p-xylene were measured in the dilute concentration regions at several temperatures ranging from 278 to 313 K under ambient pressure. The partial molar volumes of the solvents and solute were calculated. They are independent of concentration and increase slightly as the temperature increases. The viscosity A- and B-coefficients of the Jones-Dole equation were obtained. The A-coefficients were found to be zero within experimental error. The B-coefficients are positive and decrease as the temperature increases. Thermodynamic quantities of activation for viscous flow were calculated on the basis of Eyring’s viscosity equation. From the quantities obtained in this study, along with some information from the literature, it is suggested that structure-making interactions occur between the segments of the complex and the solvent molecules. These interactions include electrostatic interactions between the local charge on the complex and the dipole moment of the solvent in solutions of acetonitrile and dichloromethane, interlocking packing interactions along C ₃-axis of the complex with solvent in solutions of chloroform and tetrachloromethane, and π-electron interactions between the chelate ring of the complex and the solvent in solutions of benzene, toluene, ethylbenzene, and p-xylene.     

Solvation number and conformation of N,N-dimethylacrylamide and N,N-dimethylpropionamide in the coordination sphere of the cobalt(II) ion in solution studied by FT-IR and FT-Raman spectroscopy.

The solvation number and conformation of N,N-dimethylacrylamide (DMAA) in the coordination sphere of the cobalt(II) ion in solution were studied, and compared with those of N,N-dimethylpropionamide (DMPA) by means of FT-Raman and FT-IR spectroscopy. Both solvents are present as either the planar cis or nonplanar staggered conformer in equilibrium, and the former is more stable in the bulk. As these solvents solvate the metal ion through the carbonyl O atom of the acryl (DMAA) or propionyl (DMPA) group, the solvation structure around the metal ion is highly congested to reduce the solvation number and/or to lead to a conformational geometry change of solvent. It turns out that the solvation number of the cobalt(II) ion is 4 for both DMAA and DMPA at 298 K, and that DMPA changes its conformation upon solvation, whereas DMAA hardly changes. The enthalpy of conformational change DeltaH degrees for DMPA is 5 kJ mol(-1) in the bulk, and is -9 kJ mol(-1) in the coordination sphere of the cobalt(II) ion. On the other hand, the DeltaH degrees value for DMAA is 9 kJ mol(-1) in the bulk.     

Intercalation of cobaltammine complex ions into layered manganese oxide

The intercalation of Co(2+), [Co(NH(3))(6)](3+), and [Co(NH(3))(5)Cl](2+) ions into layered manganese oxide (birnessite) was studied by chemical, XRD, SEM, IR, and DTA-TG analyses. The intercalation reaction progressed by a 2:1 or 3:1 ion-exchange mechanism depending on the valence of the starting ions. The oxidation state of cobalt did not change with the intercalation reaction. The intercalation of [Co(NH(3))(6)](3+) ions resulted in an increase of basal spacing from 0.716 to 0.956 nm, giving a layered structure material consisting mainly of platelike particles. The chemical analysis results showed that the structure of [Co(NH(3))(6)](3+) ions was maintained in the interlayer. On the other hand, an H(2)O/NH(3) ligand exchange reaction progressed for the intercalation of [Co(NH(3))(5)Cl](2+) ions, resulting in an increase in the basal spacing from 0.716 to 0.956 nm.     

An iridoid glucoside dimer and a non-glycosidic iridoid from the leaves of Lasianthus wallichii

A new iridoid glucoside dimer (1) and a non-glycosidic iridoid (2) was isolated together with the known compounds, asperuloside (3), paederoside (4), daphylloside (5), citroside A (6) and benzyl 6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranoside (7), from the leaves of Lasianthus wallichii. The structures of the new compounds were elucidated by spectroscopic and chemical evidence.     

Ring-opening fluorination of bicyclic azaarenes

We have discovered a ring-opening fluorination of bicyclic azaarenes. Upon treatment of bicyclic azaarenes such as pyrazolo[1,5-a]pyridines with electrophilic fluorinating agents, fluorination of the aromatic ring is followed by a ring-opening reaction. Although this overall transformation can be classified as an electrophilic fluorination of an aromatic ring, it is a novel type of fluorination that results in construction of tertiary carbon–fluorine bonds. The present protocol can be applied to a range of bicyclic azaarenes, tolerating azines and a variety of functional groups. Additionally, mechanistic studies and enantioselective fluorination have been examined.

A ring-opening fluorination of bicyclic azaarenes was developed. Although this overall transformation can be classified as an electrophilic fluorination of aromatics, it is a novel type of fluorination that results in construction of tert-C–F bonds.     

Effects of Early Physical Therapist-supervised Walking on Clinical Outcomes after Liver Resection: Propensity Score Matching Analysis

Objective: The study aimed to demonstrate the significance of early postoperative physical therapy interventions on clinical outcomes by determining the influence of the distance walked under the supervision of a physical therapist in the early postoperative period after liver cancer. Methods: All consecutive patients who underwent surgery for liver cancer between April 2018 and March 2020 were eligible for enrollment in the study. The total walking distance during physical therapy till the third postoperative day was examined. The clinical outcomes comprised duration of postoperative hospital stay, time to independent walking, and occurrence of postoperative complications. For data analysis, the patients were divided into two groups: those who walked more than the median total distance (the long-distance group) and those who walked less than the median distance (the short-distance group). We used propensity score matching to match the background characteristics between the groups. Results: Of the 65 patients who were eligible, 14 patients were included in the two groups each, after matching. The long-distance walking group had a significantly shorter hospital stay (9.0 days vs. 11.0 days, p=0.008) and a shorter time to independent walking (3.5 days vs. 7.5 days, p=0.019) than the short-distance walking group. There were no significant differences in postoperative complications between the two groups (7.1% vs. 42.8%, p=0.08). Conclusion: In the early postoperative period after liver cancer surgery, increasing the walking distance under the supervision of a physical therapist is important for improving clinical outcomes. Further prospective studies are needed to confirm the findings of this study.     

Behavior of nitroxyl radical in the polymerization process forming copolymers bearing diarylnitrone pendants and photocontrol of refractive indices for these copolymers

To establish the reaction condition under which the radical copolymerization of methyl methacrylate (MMA) with α‐(2‐hydroxy‐4‐methacryloyloxyphenyl)‐N‐(2,6‐dimethylphenyl)nitrone (HMDN) proceeds smoothly to give photoreactive copolymers, the effects of the nitrone chromophore on the extent to which the radical polymerization of MMA is inhibited were investigated. It was found that the reversible addition of initiating radical to the CH?N⁺(? O^?) moiety in the nitrone chromophore readily occurs to give the nitroxyl radical. It was also found that the latter radical undergoes an efficient coupling reaction with propagating radical to inhibit the radical copolymerization of MMA with HMDN. However, on raising the reaction temperature and the radical concentration, the copolymerization was successfully carried out. This polymerization condition allowed us to prepare the HMDN/MMA, HMDN/styrene, and HMDN/cyclohexyl acrylate copolymers in good yields. The photoirradiation of the copolymer film prepared on a silicon wafer lowered its refractive index by 0.003–0.023, depending on the relative composition of the diarylnitrone chromophore in these copolymers. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 88–97, 2006     

Abilities of 2‐arylmethyloxy‐6‐cyanonaphthalene derivatives to initiate radical and cationic photopolymerizations

An investigation was undertaken to shed much light on the bond‐cleavage mode (heterolysis vs homolysis) of bichromophoric photoinitiators in styrene (St) and 1,2‐epoxycyclohexane (EpC) and then to develop a highly efficient hybrid‐type photoinitiator. Excited‐state 2‐(9‐anthrylmethyloxy)‐6‐cyanonaphthalene in toluene and 1,2‐dimethoxyethane, which were used instead of St and EpC, respectively, underwent both homolytic Ar? OCH₂ bond cleavage and heterolytic ArO? CH₂ bond cleavage to give the corresponding radical‐pair and ion‐pair intermediates. The charge‐separated state characteristic of the naphthol chromophore in the singlet excited state was found to play a pivotal role in this heterolytic bond‐cleavage mode. An inspection of the radical (St) and cationic (EpC) photopolymerization behavior observed in the presence of some 2‐arylmethyloxy‐6‐cyanonaphthalenes led us to conclude that the aforementioned 9‐anthrylmethyloxy‐substituted naphthalene derivative is a candidate for a functional hybrid‐type photoinitiator containing no halogen and/or metal. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 25–31, 2006